Gene Information

Name : covR (MGAS2096_Spy0300)
Accession : YP_599896.1
Strain : Streptococcus pyogenes MGAS2096
Genome accession: NC_008023
Putative virulence/resistance : Virulence
Product : response regulator CsrR
Function : -
COG functional category : T : Signal transduction mechanisms
COG ID : COG0745
EC number : -
Position : 298655 - 299341 bp
Length : 687 bp
Strand : +
Note : -

DNA sequence :
ATGACAAAGAAGATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCTGTTGAGACTCATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Protein sequence :
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETHVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
copR NP_460069.2 transcriptional regulatory protein YedW Not tested SPI-5 Protein 1e-36 43
copR AAC33719.1 regulatory protein CopR Not tested SPI-5 Protein 4e-36 42
unnamed CAD42044.1 hypothetical protein Not tested PAI II 536 Protein 6e-34 41
c3565 NP_755440.1 response regulator Not tested PAI I CFT073 Protein 1e-33 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
covR YP_599896.1 response regulator CsrR HE999704.1.gene1528. Protein 8e-59 61
covR YP_599896.1 response regulator CsrR NC_007793.3914065.p0 Protein 4e-51 53
covR YP_599896.1 response regulator CsrR NC_002758.1121390.p0 Protein 4e-51 53
covR YP_599896.1 response regulator CsrR NC_010079.5776364.p0 Protein 4e-51 53
covR YP_599896.1 response regulator CsrR NC_002952.2859858.p0 Protein 4e-51 53
covR YP_599896.1 response regulator CsrR NC_007622.3794948.p0 Protein 4e-51 53
covR YP_599896.1 response regulator CsrR AE015929.1.gene1106. Protein 4e-49 53
covR YP_599896.1 response regulator CsrR NC_003923.1003417.p0 Protein 4e-51 53
covR YP_599896.1 response regulator CsrR NC_013450.8614146.p0 Protein 4e-51 53
covR YP_599896.1 response regulator CsrR NC_002951.3238224.p0 Protein 4e-51 53
covR YP_599896.1 response regulator CsrR NC_012469.1.7685629. Protein 2e-38 43
covR YP_599896.1 response regulator CsrR HE999704.1.gene2815. Protein 2e-39 42
covR YP_599896.1 response regulator CsrR BAC0125 Protein 8e-36 41
covR YP_599896.1 response regulator CsrR AE016830.1.gene1681. Protein 2e-39 41
covR YP_599896.1 response regulator CsrR BAC0197 Protein 3e-32 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
covR YP_599896.1 response regulator CsrR VFG1390 Protein 3e-41 43
covR YP_599896.1 response regulator CsrR VFG0596 Protein 4e-37 43
covR YP_599896.1 response regulator CsrR VFG1563 Protein 3e-34 41
covR YP_599896.1 response regulator CsrR VFG1702 Protein 6e-34 41