Gene Information

Name : leuS (MGAS2096_Spy0154)
Accession : YP_599750.1
Strain : Streptococcus pyogenes MGAS2096
Genome accession: NC_008023
Putative virulence/resistance : Unknown
Product : leucyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0495
EC number : 6.1.1.4
Position : 162974 - 165475 bp
Length : 2502 bp
Strand : +
Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl

DNA sequence :
ATGACATTTTACGATCACACCGCTATTGAACCCAAATGGCAAGCCTTTTGGGCAGATAATCACACCTTTAAAACAGGAAC
AGACGCATCAAAACCTAAGTTTTATGCCCTAGATATGTTCCCATATCCATCAGGAGCTGGTCTCCACGTTGGTCACCCAG
AAGGCTATACAGCAACTGATATTCTTAGCCGTTTCAAACGTGCCCAAGGTCACAATGTCCTCCACCCAATGGGTTGGGAT
GCCTTTGGACTTCCTGCTGAGCAGTACGCTATGGATACTGGTAATGATCCAGCCGAGTTTACAGCTGAAAACATCGCTAA
CTTCAAACGCCAGATTAATGCTCTTGGCTTCTCATACGACTGGGACCGTGAAGTTAACACAACTGACCCTAACTACTACA
AGTGGACGCAGTGGATCTTTACCAAGCTTTATGAAAAAGGTCTAGCCTACGAAGCTGAAGTTCCCGTTAACTGGGTTGAA
GAATTGGGAACAGCTATCGCCAACGAAGAGGTTCTTCCAGATGGGACATCAGAACGTGGCGGCTATCCAGTTGTCAGAAA
ACCCATGCGCCAATGGATGCTCAAAATCACTGCCTATGCAGAGCGCTTGCTAGAAGACTTGGAAGAAGTTGACTGGCCAG
AATCAATCAAGGACATGCAACGCAACTGGATTGGTAAATCAACTGGCGCTAATGTAACCTTCAAGGTTAAGGATACAGAT
AAGGACTTCACTGTCTTTACAACACGTCCTGACACGCTTTTTGGTGCAACTTACGCCGTTCTTGCTCCTGAGCATGCCTT
GGTTGATGCTATTACGACATCTGACCAGGCAGAAGCCGTGGCTGACTACAAACGTCAAGCAAGTCTCAAATCAGACCTTG
CTCGTACAGACCTTGCCAAAGAAAAAACTGGTGTCTGGACGGGTAGCTATGCGATTAACCCGGTCAACGGCAAAGAAATG
CCAGTTTGGATTGCGGACTATGTCCTTGCTAGCTACGGTACTGGTGCTATCATGGCTGTTCCAGCCCACGATGAACGTGA
CTGGGAATTCGCAAAACAATTTAACCTAGACATCATCCCTGTTCTTGAAGGTGGTAATGTTGAAGAGGCTGCCTTTACAG
AAGACGGTCTTCACATCAACTCCGACTTCCTAGATGGTCTTGACAAAGCGTCAGCTATTGCCAAAATGGTCGAATGGCTT
GAAGCAGAAGGCGTCGGTAATGAAAATGTCACTTACCGTCTCCGTGACTGGCTCTTTAGCCGTCAACGTTACTGGGGTGA
GCCAATCCCAATCATCCACTGGGAAGATGGGACATCAACAGCGGTTCCTGAGAGTGAATTGCCATTGGTTCTTCCAGTAA
CTAAGGATATTCGTCCTTCAGGTACTGGTGAGAGCCCGCTTGCTAACGTGACAGACTGGTTGGAAGTTACCCGTGAAGAT
GGTGTTAAAGGTCGTCGTGAGACTAACACCATGCCACAATGGGCAGGTTCAAGCTGGTATTATCTTCGTTACATCGATCC
ACACAACACCGAAAAACTGGCTGATGAGGAACTCCTCAAACAATGGTTGCCAGTTGATATCTATGTCGGTGGTGCAGAGC
ATGCCGTGCTTCACCTTCTCTACGCTCGCTTCTGGCACAAGGTTCTTTACGATCTCGGTGTTGTACCTACCAAAGAGCCA
TTCCAAAAACTCTTTAACCAAGGGATGATTTTGGGGACAAGCTACCGCGATAGCCGTGGAGCGCTTGTAGCGACTGACAA
GGTTGAAAAACGTGATGGCAGCTTCTTCCATGTGGAAACTGGGGAAGAGCTTGAACAAGCACCAGCTAAGATGTCTAAAT
CACTTAAGAACGTCGTCAACCCAGATGATGTTGTTGAGCAGTACGGTGCTGACACCCTTCGTGTTTACGAGATGTTCATG
GGACCACTTGACGCTTCCATCGCTTGGTCTGAAGAAGGTCTTGAAGGCTCACGTAAGTTCTTGGACCGTGTTTACCGTTT
GATCACGACTAAAGAGATCACTGAGGAAAATAGCGGAGCCCTTGACAAGGTTTACAACGAAACCGTTAAGGCCGTTACTG
AGCAAGTTGACCAAATGAAATTCAACACAGCTATCGCTCAACTCATGGTATTTGTCAATGCAGCCAACAAGGAAGACAAA
CTCTTTAGCGACTATGCCAAAGGCTTTGTTCAATTGATTGCACCATTTGCACCGCACTTAGGTGAGGAACTCTGGCAAGC
CTTGACAGCCTCAGGTGAGTCAATCTCTTACGTGCCATGGCCAAGTTATGATGAAAGCAAATTGGTTGAAAACGATGTGG
AAATCGTTGTCCAAATCAAAGGTAAGGTCAAAGCTAAACTTGTAGTTGCTAAAGACCTTTCACGCGAAGAATTACAAGAA
GTTGCCCTTGCTAACGAAAAAGTCCAAGCCGAAATCGCAGGCAAAGACATCATCAAAGTCATCGCAGTACCAAACAAACT
CGTTAATATTGTTATCAAATAG

Protein sequence :
MTFYDHTAIEPKWQAFWADNHTFKTGTDASKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGHNVLHPMGWD
AFGLPAEQYAMDTGNDPAEFTAENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVE
ELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKDMQRNWIGKSTGANVTFKVKDTD
KDFTVFTTRPDTLFGATYAVLAPEHALVDAITTSDQAEAVADYKRQASLKSDLARTDLAKEKTGVWTGSYAINPVNGKEM
PVWIADYVLASYGTGAIMAVPAHDERDWEFAKQFNLDIIPVLEGGNVEEAAFTEDGLHINSDFLDGLDKASAIAKMVEWL
EAEGVGNENVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRPSGTGESPLANVTDWLEVTRED
GVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEELLKQWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEP
FQKLFNQGMILGTSYRDSRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFM
GPLDASIAWSEEGLEGSRKFLDRVYRLITTKEITEENSGALDKVYNETVKAVTEQVDQMKFNTAIAQLMVFVNAANKEDK
LFSDYAKGFVQLIAPFAPHLGEELWQALTASGESISYVPWPSYDESKLVENDVEIVVQIKGKVKAKLVVAKDLSREELQE
VALANEKVQAEIAGKDIIKVIAVPNKLVNIVIK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
leuS YP_281511.2 leucyl-tRNA synthetase Not tested Not named Protein 0.0 100