Gene Information

Name : MGAS2096_Spy1149 (MGAS2096_Spy1149)
Accession : YP_600745.1
Strain : Streptococcus pyogenes MGAS2096
Genome accession: NC_008023
Putative virulence/resistance : Resistance
Product : tetracycline resistance protein tetM
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0480
EC number : -
Position : 1101269 - 1103188 bp
Length : 1920 bp
Strand : -
Note : -

DNA sequence : 
ATGAAAATAATTAACTTAGGCATTCTGGCTCACGTTGACGCAGGAAAGACAACATTAACGGAAAGTTTATTATATACCAG
TGGTGCAATTGCAGAACTAGGGAGCGTAGATGAAGGCACAACAAGGACAGATACAATGAATTTGGAGCGTCAAAGGGGAA
TCACTATCCAGACAGCAGTGACATCTTTTCAGTGGGAGGATGTAAAAGTCAACATTATAGATACGCCAGGCCATATGGAT
TTTTTGGCGGAAGTATACCGTTCTTTATCCGTTTTAGACGGAGCAGTATTATTAGTTTCTGCAAAGGATGGCATACAGGC
ACAGACCCGTATACTGTTTCATGCACTACAGACAATGAAGATTCCGACAATCTTTTTCATCAATAAAATTGACCAAGAGG
GGATTGATTTGCCAATGGTATATCGGGAAATGAAAGCAAAGCTTTCTTCGGAAATTATAGTGAAGCAAAAGGTTGGGCAG
CATCCCCATATAAATGTAACGGACAATGACGATATGGAACAGTGGGATGCGGTAATTATGGGAAACGATGAACTATTAGA
GAAATATATGTCAGGGAAACCGTTTAAAATGTCAGAACTGGAACAGGAAGAAAACAGGAGATTCCAAAACGGAACGTTAT
TTCCCGTTTATCACGGAAGCGCTAAAAACAATCTGGGGATTCGGCAGCTTATAGAAGTGATTGCCAGTAAATTTTATTCA
TCAACGCCTGAAGGTCAATCTGAACTATGCGGGCAGGTTTTTAAGATTGAATATTCAGAGAAAAGGCGGCGTTTTGTTTA
TGTGCGTATATATAGCGGAACATTGCATTTGAGGGATGTTATTAGAATATCTGAAAAAGAGAAAATAAAAATCACAGAGA
TGTGTGTTCCGACAAACGGTGAATTATATTCATCCGATACAGCCTGCTCTGGTGATATTGTAATTTTACCAAATGATGTT
TTGCAGCTAAACAGTATTTTGGGGAACGAAATGCTGTTGCCGCAGAGAAAATTTATTGAAAATCCTCTCCCTATGCTCCA
AACAACGATTGCAGTAAAGAAATCTGAACAGCGGGAAATATTGCTTGGGGCACTTACAGAAATTTCAGATGGCGACCCTC
TTTTAAAATATTATGTGGATACTACAACGCATGAGATTATACTTTCTTTTTTGGGGAATGTGCAGATGGAAGTCATTTGT
GCCATCCTTGAGGAAAAATATCATTTGGAGGCAGAAATAAAAGAGCCTACTGTTATATATATGGAAAGACCGCTTAGAAA
AGCAGAATATACCATCCACATAGAAGTCCCGCCAAATCCTTTCTGGGCTTCTGTCGGGTTGTCCATAGAGCCGCTCCCTA
TTGGAAGCGGAGTGCAGTATGAAAGCAGAGTTTCACTTGGATATTTAAACCAATCGTTCCAAAATGCGGTTATGGAGGGG
GTTCTTTATGGCTGCGAGCAGGGGCTGTATGGATGGAAAGTGACAGACTGTAAAATCTGTTTTGAATATGGATTGTATTA
TAGTCCTGTAAGTACCCCCGCAGACTTTCGGCTGCTTTCCCCTATCGTATTGGAGCAGGCTTTAAAAAAAGCAGGGACAG
AACTATTAGAGCCATATCTCCACTTTGAAATTTATGCACCGCAGGAATATCTCTCACGGGCGTATCATGATGCTCCAAGG
TATTGTGCAGATATTGTAAGTACTCAGATAAAGAATGACGAGGTCATTCTGAAAGGAGAAATCCCTGCCAGATGTATTCA
AGAATACAGGAACGATTTAACTTATTTCACAAATGGGCAGGGAGTCTGCTTGACAGAGTTAAAAGGATACCATCCAGCTA
TTGGTAAATTTATTTGCCAACCCCGCCGCCCGAATAGCCGTATAGATAAGGTTCGGCATATGTTCCACAAGTTAGCTTAA

Protein sequence : 
MKIINLGILAHVDAGKTTLTESLLYTSGAIAELGSVDEGTTRTDTMNLERQRGITIQTAVTSFQWEDVKVNIIDTPGHMD
FLAEVYRSLSVLDGAVLLVSAKDGIQAQTRILFHALQTMKIPTIFFINKIDQEGIDLPMVYREMKAKLSSEIIVKQKVGQ
HPHINVTDNDDMEQWDAVIMGNDELLEKYMSGKPFKMSELEQEENRRFQNGTLFPVYHGSAKNNLGIRQLIEVIASKFYS
STPEGQSELCGQVFKIEYSEKRRRFVYVRIYSGTLHLRDVIRISEKEKIKITEMCVPTNGELYSSDTACSGDIVILPNDV
LQLNSILGNEMLLPQRKFIENPLPMLQTTIAVKKSEQREILLGALTEISDGDPLLKYYVDTTTHEIILSFLGNVQMEVIC
AILEEKYHLEAEIKEPTVIYMERPLRKAEYTIHIEVPPNPFWASVGLSIEPLPIGSGVQYESRVSLGYLNQSFQNAVMEG
VLYGCEQGLYGWKVTDCKICFEYGLYYSPVSTPADFRLLSPIVLEQALKKAGTELLEPYLHFEIYAPQEYLSRAYHDAPR
YCADIVSTQIKNDEVILKGEIPARCIQEYRNDLTYFTNGQGVCLTELKGYHPAIGKFICQPRRPNSRIDKVRHMFHKLA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tetO AFJ97266.1 truncated tetracycline resistant protein Not tested Not named Protein 0.0 98
SSU05_0922 YP_001198287.1 translation elongation factor (GTPases) Not tested 89K Protein 0.0 77
SSU98_0928 YP_001200485.1 translation elongation factor (GTPases) Not tested 89K Protein 0.0 77
tet(W) YP_005160006.1 tetracycline resistance protein Not tested Not named Protein 0.0 68

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
MGAS2096_Spy1149 YP_600745.1 tetracycline resistance protein tetM AJ295238.gene.p01 Protein 0.0 80
MGAS2096_Spy1149 YP_600745.1 tetracycline resistance protein tetM AM180355.1.gene636.p Protein 0.0 78
MGAS2096_Spy1149 YP_600745.1 tetracycline resistance protein tetM X04388.gene.p01 Protein 0.0 77
MGAS2096_Spy1149 YP_600745.1 tetracycline resistance protein tetM M85225.gene.p01 Protein 0.0 77
MGAS2096_Spy1149 YP_600745.1 tetracycline resistance protein tetM NC_009782.5559075.p0 Protein 0.0 76
MGAS2096_Spy1149 YP_600745.1 tetracycline resistance protein tetM NC_002758.1120355.p0 Protein 0.0 76
MGAS2096_Spy1149 YP_600745.1 tetracycline resistance protein tetM L09756.gene.p01 Protein 0.0 72
MGAS2096_Spy1149 YP_600745.1 tetracycline resistance protein tetM AY485126.gene.p01 Protein 0.0 70
MGAS2096_Spy1149 YP_600745.1 tetracycline resistance protein tetM AJ222769.gene.p01 Protein 0.0 68
MGAS2096_Spy1149 YP_600745.1 tetracycline resistance protein tetM FN594949.1.gene24.p0 Protein 0.0 68
MGAS2096_Spy1149 YP_600745.1 tetracycline resistance protein tetM DQ294299.gene.p01 Protein 0.0 67
MGAS2096_Spy1149 YP_600745.1 tetracycline resistance protein tetM AJ514254.gene.p01 Protein 2e-115 44
MGAS2096_Spy1149 YP_600745.1 tetracycline resistance protein tetM L42544.gene.p01 Protein 2e-118 44