Gene Information

Name : metB (MGAS10270_Spy0148)
Accession : YP_597757.1
Strain : Streptococcus pyogenes MGAS10270
Genome accession: NC_008022
Putative virulence/resistance : Unknown
Product : Cystathionine beta-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.8
Position : 161660 - 163051 bp
Length : 1392 bp
Strand : +
Note : -

DNA sequence :
GTGTTGGCAGCTTGGTCAAAGATGATAAAAGGGCTTGCAAACTTAGCTAAAGGTTGTATAATAAACGTAATCGATCTAAA
AATGATATTGTTGGAAAAATTCATTATCCATTTAAAAGGTGTCCACTACTTTTCTTGTAGGTTAGCAGATCACGCTTTTT
TGAAGAGCTTTTTGGCTTGTGCAACCATTGGGGTGGGACCATTGTCTAAAAGAGAGTTCATTGGAGTTAACGCTATTGCG
GAGGTGCACGAAATGAGAGAAAATACGACCTTATTACATGGCTATACGGTTATTGATGAGTTTACAGGAGCAGCTTCAGT
TCCCATCTATCAGACTTCGACGTTCCACAATTCAGAACTGTATTGTCCTAGTCAAAAACATTTGTACACACGCTTTTCAA
ACCCAACGACTGAAGCTTTAGAAGACGGGTTAGCCTGTTTAGAAAAAGCGACTTATGCGGTGGCTTATGCATCTGGTATG
GCTGCTATTTCAACTGTTTTGATGCTCTTAAAAGCTGGAGATCATGTGATTTTCCCATTGGAGGTCTATGGAGGGACTTG
TCAATTTGCGACAGCTATTTTACCCAATTATCAGATTGAAACAAGCTTTGTAGATATGGCTGATTTAGCAACAGTAAAAG
CAAGTATCAGGCCTAATACGCGTATGATTTATCTAGAGACACCGTCAAATCCGCTCTTGAAAATTTGTGATATTTCAGAG
CTTGTGCAACTCGCCAAAGCTTATGGTGTGCTAACTGTGGCTGATAATACCTTTATGACAAGTTTGTATCAAGAACCCTT
AGCTATGGGTGTGGATATTGTGGTAGAAAGTGTGACAAAATTTATCAATGGTCATAGTGATGTGGTAGCTGGTTTAGCTG
CTACCAATAATGAGGCTATCTACAACCAGCTCAAGCTTTTTCAAAAAAACTTTGGAGCAATTGTTGGGGTCGAAGACGCT
TGGCTGATTCTTCGTGGCATGAAAACTATGGGGATCCGTATGGAACAAGCGGTAAAAAATGCTCAGCAGCTCGCTAACTA
TTTAGCGAAGCACCCCAAAGTTCTTAAGGTACATTACCCTGGCTTAGACAGTCATCCTAATCACGATACCCACCTGCAAC
AAGCTAAGAATGGTGGTGCTGTTTTATCCTTTGAGTTGGCTTCTAAGGAGGAGCTGATGACCTTTACCCATCGTATTCAG
TTGCCGATTTTAGCTGTTAGTCTAGGTGGAGTAGAGTCCATTTTGTCACATCCAGCAACGATGTCTCATACTTGTTTATC
ATCACAAGCGCGGTTGGAACAAGGGGTTGTTGATGGTTTGCTGCGCTTGTCTTGTGGTGTTGAAAATATCGAAGACTTAT
TGGCCGATTTTGAGCAAGCACTTGCTTTTTAA

Protein sequence :
MLAAWSKMIKGLANLAKGCIINVIDLKMILLEKFIIHLKGVHYFSCRLADHAFLKSFLACATIGVGPLSKREFIGVNAIA
EVHEMRENTTLLHGYTVIDEFTGAASVPIYQTSTFHNSELYCPSQKHLYTRFSNPTTEALEDGLACLEKATYAVAYASGM
AAISTVLMLLKAGDHVIFPLEVYGGTCQFATAILPNYQIETSFVDMADLATVKASIRPNTRMIYLETPSNPLLKICDISE
LVQLAKAYGVLTVADNTFMTSLYQEPLAMGVDIVVESVTKFINGHSDVVAGLAATNNEAIYNQLKLFQKNFGAIVGVEDA
WLILRGMKTMGIRMEQAVKNAQQLANYLAKHPKVLKVHYPGLDSHPNHDTHLQQAKNGGAVLSFELASKEELMTFTHRIQ
LPILAVSLGGVESILSHPATMSHTCLSSQARLEQGVVDGLLRLSCGVENIEDLLADFEQALAF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 0.0 99
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 9e-77 43
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 4e-77 43