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Name : guaA (MGAS9429_Spy1021) Accession : YP_596752.1 Strain : Streptococcus pyogenes MGAS9429 Genome accession: NC_008021 Putative virulence/resistance : Unknown Product : GMP synthase Function : - COG functional category : F : Nucleotide transport and metabolism COG ID : COG0519 EC number : 6.3.5.2 Position : 977535 - 979097 bp Length : 1563 bp Strand : + Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway DNA sequence : ATGACTGAAATTTCAATTTTGAATGATGTTCAAAAAATTATCGTTCTTGATTATGGTAGCCAGTACAATCAGCTTATTGC TAGACGTATTCGAGAGTTTGGTGTTTTCTCCGAACTAAAAAGCCATAAAATCACCGCTCAAGAACTTCGTGAGATCAATC CCATAGGTATCGTTTTATCAGGAGGGCCTAACTCTGTTTACGCTGATAACGCCTTTGGCATTGACCCTGAAATCTTTGAA CTAGGGATTCCGATTCTTGGTATCTGTTACGGTATGCAATTAATCACCCATAAATTAGGTGGTAAAGTTGTTCCTGCTGG ACAAGCTGGTAATCGTGAATACGGTCAGTCAACCCTTCATCTTCGTGAAACGTCAAAATTATTTTCAGGCACACCTCAAG AACAACTCGTTTTAATGAGCCATGGTGATGCTGTTACTGAAATTCCAGAAGGTTTCCACCTTGTTGGAGACTCAAATGAC TGTCCCTATGCAGCTATTGAAAATACTGAGAAAAACCTTTACGGTATTCAGTTCCACCCAGAAGTAAGACACTCTGTTTA TGGAAATGACATTCTTCAAAACTTTGCTATATCAATTTGTGGCGCGCGTGGTGATTGGTCAATGGATAATTTTATTGACA TGGAAATTGCTAAAATTCGTGAAACTGTAGGCGATCGTAAAGTTCTTCTAGGTCTTTCTGGTGGAGTTGATTCTTCAGTT GTTGGTGTTCTACTTCAAAAAGCTATCGGTGACCAATTAACTTGTATTTTCGTTGATCACGGTCTTCTTCGTAAAGACGA GGGCGATCAAGTTATGGGAATGCTTGGGGGCAAATTTGGCCTAAATATTATCCGTGTGGATGCTTCAAAACGTTTCTTAG ACCTTCTTGCAGACGTTGAAGATCCTGAGAAAAAACGTAAAATTATTGGTAATGAATTTGTCTATGTTTTTGATGATGAA GCCAGCAAATTAAAAGGTGTTGACTTCCTTGCCCAAGGAACACTTTATACTGATATCATTGAGTCAGGAACAGAAACTGC TCAAACCATCAAATCACATCACAATGTGGGTGGTCTCCCCGAAGACATGCAGTTTGAATTGATTGAGCCCTTAAACACTC TTTTCAAAGATGAAGTTCGAGCGCTTGGAATCGCTCTTGGAATGCCTGAAGAAATTGTTTGGCGCCAACCATTTCCAGGT CCTGGACTTGCTATCCGTGTCATGGGAGCAATTACTGAAGAAAAACTTGAAACCGTTCGCGAATCAGACGCTATCCTTCG TGAAGAAATTGCTAAGGCTGGACTTGATCGTGACGTGTGGCAATACTTTACAGTTAACACAGGTGTCCGTTCTGTAGGCG TCATGGGAGATGGTCGTACTTATGATTATACCATCGCCATTCGTGCTATTACGTCTATTGATGGTATGACAGCTGACTTT GCTCAACTTCCTTGGGATGTCTTGAAAAAAATCTCAACACGTATCGTAAATGAAGTTGACCACGTTAACCGTATCGTCTA CGACATCACAAGTAAACCACCCGCAACAGTTGAATGGGAATAA Protein sequence : MTEISILNDVQKIIVLDYGSQYNQLIARRIREFGVFSELKSHKITAQELREINPIGIVLSGGPNSVYADNAFGIDPEIFE LGIPILGICYGMQLITHKLGGKVVPAGQAGNREYGQSTLHLRETSKLFSGTPQEQLVLMSHGDAVTEIPEGFHLVGDSND CPYAAIENTEKNLYGIQFHPEVRHSVYGNDILQNFAISICGARGDWSMDNFIDMEIAKIRETVGDRKVLLGLSGGVDSSV VGVLLQKAIGDQLTCIFVDHGLLRKDEGDQVMGMLGGKFGLNIIRVDASKRFLDLLADVEDPEKKRKIIGNEFVYVFDDE ASKLKGVDFLAQGTLYTDIIESGTETAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGIALGMPEEIVWRQPFPG PGLAIRVMGAITEEKLETVRESDAILREEIAKAGLDRDVWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADF AQLPWDVLKKISTRIVNEVDHVNRIVYDITSKPPATVEWE |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| SAMSHR1132_03620 | YP_005324884.1 | GMP synthase | Not tested | vSa¥á | Protein | 8e-175 | 69 |
| guaA | YP_001331415.1 | GMP synthase | Not tested | vSa¥á | Protein | 5e-175 | 69 |
| SAPIG0468 | YP_005733278.1 | GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) | Not tested | SAPI-S0385 | Protein | 1e-174 | 69 |
| guaA | NP_938969.1 | GMP synthase | Not tested | Not named | Protein | 2e-119 | 52 |
