Gene Information

Name : guaA (MGAS9429_Spy1021)
Accession : YP_596752.1
Strain : Streptococcus pyogenes MGAS9429
Genome accession: NC_008021
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 977535 - 979097 bp
Length : 1563 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACTGAAATTTCAATTTTGAATGATGTTCAAAAAATTATCGTTCTTGATTATGGTAGCCAGTACAATCAGCTTATTGC
TAGACGTATTCGAGAGTTTGGTGTTTTCTCCGAACTAAAAAGCCATAAAATCACCGCTCAAGAACTTCGTGAGATCAATC
CCATAGGTATCGTTTTATCAGGAGGGCCTAACTCTGTTTACGCTGATAACGCCTTTGGCATTGACCCTGAAATCTTTGAA
CTAGGGATTCCGATTCTTGGTATCTGTTACGGTATGCAATTAATCACCCATAAATTAGGTGGTAAAGTTGTTCCTGCTGG
ACAAGCTGGTAATCGTGAATACGGTCAGTCAACCCTTCATCTTCGTGAAACGTCAAAATTATTTTCAGGCACACCTCAAG
AACAACTCGTTTTAATGAGCCATGGTGATGCTGTTACTGAAATTCCAGAAGGTTTCCACCTTGTTGGAGACTCAAATGAC
TGTCCCTATGCAGCTATTGAAAATACTGAGAAAAACCTTTACGGTATTCAGTTCCACCCAGAAGTAAGACACTCTGTTTA
TGGAAATGACATTCTTCAAAACTTTGCTATATCAATTTGTGGCGCGCGTGGTGATTGGTCAATGGATAATTTTATTGACA
TGGAAATTGCTAAAATTCGTGAAACTGTAGGCGATCGTAAAGTTCTTCTAGGTCTTTCTGGTGGAGTTGATTCTTCAGTT
GTTGGTGTTCTACTTCAAAAAGCTATCGGTGACCAATTAACTTGTATTTTCGTTGATCACGGTCTTCTTCGTAAAGACGA
GGGCGATCAAGTTATGGGAATGCTTGGGGGCAAATTTGGCCTAAATATTATCCGTGTGGATGCTTCAAAACGTTTCTTAG
ACCTTCTTGCAGACGTTGAAGATCCTGAGAAAAAACGTAAAATTATTGGTAATGAATTTGTCTATGTTTTTGATGATGAA
GCCAGCAAATTAAAAGGTGTTGACTTCCTTGCCCAAGGAACACTTTATACTGATATCATTGAGTCAGGAACAGAAACTGC
TCAAACCATCAAATCACATCACAATGTGGGTGGTCTCCCCGAAGACATGCAGTTTGAATTGATTGAGCCCTTAAACACTC
TTTTCAAAGATGAAGTTCGAGCGCTTGGAATCGCTCTTGGAATGCCTGAAGAAATTGTTTGGCGCCAACCATTTCCAGGT
CCTGGACTTGCTATCCGTGTCATGGGAGCAATTACTGAAGAAAAACTTGAAACCGTTCGCGAATCAGACGCTATCCTTCG
TGAAGAAATTGCTAAGGCTGGACTTGATCGTGACGTGTGGCAATACTTTACAGTTAACACAGGTGTCCGTTCTGTAGGCG
TCATGGGAGATGGTCGTACTTATGATTATACCATCGCCATTCGTGCTATTACGTCTATTGATGGTATGACAGCTGACTTT
GCTCAACTTCCTTGGGATGTCTTGAAAAAAATCTCAACACGTATCGTAAATGAAGTTGACCACGTTAACCGTATCGTCTA
CGACATCACAAGTAAACCACCCGCAACAGTTGAATGGGAATAA

Protein sequence :
MTEISILNDVQKIIVLDYGSQYNQLIARRIREFGVFSELKSHKITAQELREINPIGIVLSGGPNSVYADNAFGIDPEIFE
LGIPILGICYGMQLITHKLGGKVVPAGQAGNREYGQSTLHLRETSKLFSGTPQEQLVLMSHGDAVTEIPEGFHLVGDSND
CPYAAIENTEKNLYGIQFHPEVRHSVYGNDILQNFAISICGARGDWSMDNFIDMEIAKIRETVGDRKVLLGLSGGVDSSV
VGVLLQKAIGDQLTCIFVDHGLLRKDEGDQVMGMLGGKFGLNIIRVDASKRFLDLLADVEDPEKKRKIIGNEFVYVFDDE
ASKLKGVDFLAQGTLYTDIIESGTETAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGIALGMPEEIVWRQPFPG
PGLAIRVMGAITEEKLETVRESDAILREEIAKAGLDRDVWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADF
AQLPWDVLKKISTRIVNEVDHVNRIVYDITSKPPATVEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 8e-175 69
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 5e-175 69
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-174 69
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-119 52