Gene Information

Name : smpB (LI0225)
Accession : YP_594602.1
Strain : Lawsonia intracellularis PHE/MN1-00
Genome accession: NC_008011
Putative virulence/resistance : Unknown
Product : SsrA-binding protein
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0691
EC number : -
Position : 281262 - 281729 bp
Length : 468 bp
Strand : +
Note : binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Ca

DNA sequence :
ATGTCTGCTAAAAAAAATAGTCATCTTGTATTTGAAAATAGAAAAGCTAGACATCTTTATGATCTTCTTGATTTTCTTGA
AGCAGGAATTGTTCTTACAGGCCCTGAAGTAAAAAGTTTACGATCAGGCCATGCAAGTTTTCAAGATAGTTATGTCGACT
TTAAACAAGGTGAAGGATATATTGTAGGACTTCATATCCCTCCATATAATAATGCAGGTTATGTTATACAAAATCCTGAT
AGACCTCGAAAGTTACTTTTACATCGGCAAGAGTTGAAGATGTTAGCTTCAAAAGTAGAGCAAAAAGGACTTACAATAGT
ACCATTAAAGCTATACTTTAAAAATAGAAAAGTAAAAACAGAAATTGCATTGGCTAAAGGACGAAAGTTATATGATCATC
GTAACGAACTAAAAAAACGTGCAGAAGCTATGGATATTAAACGTGAGTTAGCTGCTCGTCATTTATAA

Protein sequence :
MSAKKNSHLVFENRKARHLYDLLDFLEAGIVLTGPEVKSLRSGHASFQDSYVDFKQGEGYIVGLHIPPYNNAGYVIQNPD
RPRKLLLHRQELKMLASKVEQKGLTIVPLKLYFKNRKVKTEIALAKGRKLYDHRNELKKRAEAMDIKRELAARHL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed AET14351.1 SsrA-binding protein Not tested SaPI68111 Protein 8e-28 47
smpB YP_001800894.1 SsrA-binding protein Not tested Not named Protein 9e-31 46
smpB NP_230495.1 SsrA-binding protein Not tested VPI-1 Protein 4e-23 45