Gene Information

Name : guaA (Nham_2542)
Accession : YP_577784.1
Strain : Nitrobacter hamburgensis X14
Genome accession: NC_007964
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2801253 - 2802875 bp
Length : 1623 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACAGCCTCCAGCAAAACCCCCGCTTCATCGTCCGGTCCGTCCCCCCATGCAGCTTCGGCGCACGACAAGATTCTCAT
CGTCGATTTTGGCAGCCAGGTCACCCAACTCATCGCGCGGCGCATTCGCGAGGAGGGCGTCTATTCCGAAATCGTGCCAT
TCCAGAAGGCGGAAGCGGCCTTCCTTGAGATGAAACCGAAGGCGGTGATCCTGTCGGGCGGACCTGCCTCCGTGCTCGAC
AAGGATGCGCCGGCGGCGCCGATGTCGATCCTCAAGGCAGGCGTGCCCGTGCTCGGCATCTGCTACGGCGAGCAGACCAT
GGCGCAGCAGCTCGGCGGCACCGTCGAGGCCGGGCATCACCGCGAGTTCGGCCGCGCCGCTATCGAGGTCACCGACACCT
GCGCGCTGTTCGAGGGTGTGTGGGAGAAGGGCGGCCACTACAACGTCTGGATGAGCCACGGCGACCGCGTCACCAAACTG
CCCGATGGCTTCCGCGCGGTGGCGAAGGCGCAGGGCTCGCCGATCGCTGTGATCGCCGACGATGCGCGCAGGTTTTATGC
GATGCAGTTTCACCCCGAGGTGGTGCATACGCCCGATGGCGCCAAGCTATTGCGTAATTTCGTCCGCAAGGTTGCGGGGC
TGACCGGCGACTGGACCATGCGCGCGTTCCGCGAGGAGGCGATCGAGAAAATCCGCGCTCAGGTCGGCAAGGGCCGGGTG
ATCTGCGGCCTGTCCGGCGGCGTCGATTCATCGGTGGCAGCGATCCTGATCCACGAGGCGATCGGCGAACAGTTGACCTG
CGTGTTCGTCGATCACGGCATGCTGCGCAAGGACGAGGGCAAGACGGTGGTGGAGCTGTTCCGCCACCACTACAATATCC
CGCTGGTCCACGTTGATGCGTCGAAGCAATTCCTGGGTGAGCTTGCCGGCGTTACCGATCCGGAGATGAAGCGCAAGACC
ATCGGCCGTCTGTTCATCGACGTGTTCGAGGCGGAAGCCAAAAAGATCGCAGCGTTAGGAAAAGGATCGGCGGAATTCCT
GGCGCAAGGCACGCTCTATCCTGACGTGATCGAGAGCGTGTCGTTCACCGGCGGCCCGTCGGTGACCATCAAGTCGCACC
ATAATGTCGGTGGCCTGCCTGATCGCATGAACATGAAACTGGTCGAGCCGTTGCGCGAACTGTTCAAGGACGAGGTCCGT
GCGTTGGGGCGCGAACTCGGGCTGCCGGAGATTTTCGTCGGCCGCCATCCGTTTCCTGGGCCGGGGCTTGCGATCCGCTG
TCCCGGTGAGATCACCCGCGAAAAACTCGACATCCTGCGCGAGGCCGATGCCGTCTATATCGACCAGATCCGCAAGGCGG
GGCTCTACGACAAGATCTGGCAGGCGTTCGCGGTGCTGCTGCCGGTGAAGACGGTCGGCGTGATGGGCGACGGCCGCACC
TATGAGTACGTGGTGGGCTTGCGCGCGGTGACCTCGACCGACGGTATGACCGCCGACTTCTATGCCTTCGACGCGACGTT
TTTGGGCGCGACCGCGACAAGCATTATCAACGAGGTCAAAGGCGTCAATCGTGTTGTCTACGACGTGACGTCAAAACCGC
CCGGCACGATCGAGTGGGAGTAG

Protein sequence :
MTASSKTPASSSGPSPHAASAHDKILIVDFGSQVTQLIARRIREEGVYSEIVPFQKAEAAFLEMKPKAVILSGGPASVLD
KDAPAAPMSILKAGVPVLGICYGEQTMAQQLGGTVEAGHHREFGRAAIEVTDTCALFEGVWEKGGHYNVWMSHGDRVTKL
PDGFRAVAKAQGSPIAVIADDARRFYAMQFHPEVVHTPDGAKLLRNFVRKVAGLTGDWTMRAFREEAIEKIRAQVGKGRV
ICGLSGGVDSSVAAILIHEAIGEQLTCVFVDHGMLRKDEGKTVVELFRHHYNIPLVHVDASKQFLGELAGVTDPEMKRKT
IGRLFIDVFEAEAKKIAALGKGSAEFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPDRMNMKLVEPLRELFKDEVR
ALGRELGLPEIFVGRHPFPGPGLAIRCPGEITREKLDILREADAVYIDQIRKAGLYDKIWQAFAVLLPVKTVGVMGDGRT
YEYVVGLRAVTSTDGMTADFYAFDATFLGATATSIINEVKGVNRVVYDVTSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 9e-129 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 7e-129 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 6e-129 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 5e-119 51