Gene Information

Name : guaA (Csal_0731)
Accession : YP_572791.1
Strain : Chromohalobacter salexigens DSM 3043
Genome accession: NC_007963
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 820084 - 821661 bp
Length : 1578 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACCGACATTCACGCCCACAAGATCCTGATTCTCGACTTCGGCTCCCAGTACACCCAGCTCATCGCGCGCCGCGTGCG
CGAGATCGGCGTCTACTCCGAAGTGCGCGCCTTCGACATCAGCGAGGAAGAGATCCGCGAGTACCGGCCCAACGGCATCA
TCCTCGCCGGCGGGCCGGAATCCGTCACCGAGCTGGCCTCGCCGCGCGCTCCGCAGTGCGTGTTCGAGATGGGCCTGCCG
GTGCTGGGGATCTGCTACGGCATGCAGACCATGGCCGAGCAGCTGGGCGGCAAGGTCGAGGGCTCGCAGAAACAGGAATT
CGGCTATGCGCAGGTGCGCATCGACGCCGACAACGCCCTGCTCAAGGACATCAAGGACCATGTCGACCATGACACCGGAC
GCGCGCTGCTCGACGTCTGGATGAGCCATGGCGACAAGGTCGCCCAGGTGCCGGAGACCTTCACCGTCACCGCCTCCACC
CCGAGCTGCCCGATCGCCGCCATGGCGTGGGAAGACAAGCAGTTCTACGGCGTGCAGTTCCACCCCGAGGTGACCCACAC
CCAGCAGGGCCAGCGCATTCTCGAGCACTTCGTGCTGGGGATCTGCCAGGCCGAGCGCCTGTGGACCCCGGCCCAGATCA
TCGACGACCTCTGCGTGCGCGTGCGCGAGCAGGTCGGCGACCGCCACGTGCTGCTCGGCCTCTCCGGCGGGGTGGATTCC
TCCGTGGTCGCCGCGCTGCTGCACAAGGCCATCGGCGATCAGCTCACCTGCGTGTTCGTCGACAACGGCCTGCTGCGCAA
GAACGAAGGCGACCAGGTGATGGAAACCTTCGCCAGCCACATGGGCGTGCGGGTGCTGCGTGTCGACGCCGAGGACGAGT
TCCTCACCAAGCTGGAAGGCGAAAACGACCCCGAAGCCAAGCGCAAGATCATCGGCAACACCTTCATCGACGTCTTCGAC
CGTGAAGCTGCCAAGATCGAGGGCGTGGACTTCCTCGCCCAGGGCACCATCTACCCGGACGTGATCGAATCCGCCGCCAG
CAAGACCGGCAAGGCGCATGTCATCAAGTCGCACCACAACGTCGGCGGCCTGCCCGAGACCATGAAGCTCAAGCTGGTCG
AACCGCTGCGCGAGCTGTTCAAGGACGAAGTGCGCAAGCTCGGTCTCGAACTCGGCCTGCCGTACGACATGGTCTACCGC
CACCCGTTCCCCGGGCCGGGCCTCGGCGTGCGTATTCTCGGCGAAGTGAAGAAAGAGTACGCCGACATCCTGCGTGAAGC
CGACGCCATCTTCATCGAGGAACTGCACAACGCCGACTGGTACCACAAGACCAGCCAGGCCTTCGCCGTCTTCCTCCCGG
TGAAATCCGTCGGCGTCGTCGGCGACGGCCGCCGCTACGAATGGGTCATCGCCCTGCGCGCCGTCGAAACCATCGACTTC
ATGACTGCAAGATGGGCGCACCTGCCGTATGAGCTGCTGGAGAAGGTCTCCAACCGCATCATCAACGAGATCAGTGGCGT
CTCCCGCGTGACGTACGACGTCAGCAGCAAGCCGCCCGCGACGATTGAGTGGGAGTGA

Protein sequence :
MTDIHAHKILILDFGSQYTQLIARRVREIGVYSEVRAFDISEEEIREYRPNGIILAGGPESVTELASPRAPQCVFEMGLP
VLGICYGMQTMAEQLGGKVEGSQKQEFGYAQVRIDADNALLKDIKDHVDHDTGRALLDVWMSHGDKVAQVPETFTVTAST
PSCPIAAMAWEDKQFYGVQFHPEVTHTQQGQRILEHFVLGICQAERLWTPAQIIDDLCVRVREQVGDRHVLLGLSGGVDS
SVVAALLHKAIGDQLTCVFVDNGLLRKNEGDQVMETFASHMGVRVLRVDAEDEFLTKLEGENDPEAKRKIIGNTFIDVFD
REAAKIEGVDFLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPETMKLKLVEPLRELFKDEVRKLGLELGLPYDMVYR
HPFPGPGLGVRILGEVKKEYADILREADAIFIEELHNADWYHKTSQAFAVFLPVKSVGVVGDGRRYEWVIALRAVETIDF
MTARWAHLPYELLEKVSNRIINEISGVSRVTYDVSSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-126 53
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 9e-127 53
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 7e-127 53
guaA NP_938969.1 GMP synthase Not tested Not named Protein 4e-116 50