Gene Information

Name : guaA (Bpro_2441)
Accession : YP_549258.1
Strain : Polaromonas sp. JS666
Genome accession: NC_007948
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2544124 - 2545743 bp
Length : 1620 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCAACACCAGAAAATCCTCATCCTCGATTTCGGCTCCCAGGTCACCCAGCTGATTGCCCGCCGCGTGCGCGATGCCCA
TGTGTTTTGCGAAGTCCATCCCTGCGATGTGACTGACGACTGGGTCCGCGACTACGCCAGGGACGGCACGCTCAAGGGCG
TCATCCTGTCCGGCAGCCATGCCAGCATCTACGAAGAAACGACCGACAAAGCGCCCCAGGCCGTGTTTGAGCTGGGCCTT
CCGGTGCTGGGCATCTGCTACGGCATGCAGGCCATGGCGCACCAGCTGGGCGGCAAGGTCGAAGGCGGCCACAAGCGCGA
ATTCGGTTCGGCTGACGTGCGGGCCCGCGGCCACACCGCGCTGCTCAAGGACATCGCCGACTACACCACGCCAGAGGGCC
AGGGCATGCTGGACGTCTGGATGAGCCACGGTGACAAGGTCACCGAAATGCCGCCGGGCTTCAAGCTCATGGCATCCACC
GAGTCCTGCCCGATCGCCGGCATGGCCGATGAAGACCGCCGTTTTTACGCGGTGCAGTTCCACCCGGAAGTCACGCACAC
CAAGCAGGGCAATGCCATTCTCAAGCGCTTTGTGCTTGATATTTGCGGCACCCGGCAAGACTGGGTCATGGGCGACTACA
TCAGCGAAGCGGTTGAAAAAATCCGCCAGCAGGTAGGCGACGAAGAGGTCATCCTCGGCCTGTCGGGCGGTGTCGATTCA
TCGGTGGCGGCGGCACTGATCCACCGCGCCATCGGCGACCAGCTGACCTGCGTATTCGTTGACCATGGCCTGCTGCGCCT
GAACGAAGGCGACATGGTGATGGACATGTTTGTCGGCAAGCTGCATGCCAGAGTGGTCCGCGTCGATGCGAGCGAGCAGT
TTCTAGGCCACCTGGCCGGGGTGAGCGAACCCGAGGCCAAGCGCAAAATCATCGGCCGGGAATTTGTCGAAGTGTTCAAG
GCCGAGGCGGCTCGGCTCAAGGCTGGCGACGGCGGCCACAAGGGCGCCAAATGGCTGGCCCAGGGCACGATTTATCCTGA
TGTGATCGAGTCCGGTGGCGCCAAGAGCAAGAAAGCCGTCACCATCAAAAGCCACCACAACGTCGGCGGCCTGCCCGAGC
AGCTGGGCCTGAAGCTGCTTGAGCCGCTGCGTGAGCTGTTCAAGGACGAGGTCCGCGAACTGGGCGTCGCGCTCGGCCTG
CCGCATGACATGGTGTATCGCCATCCCTTCCCCGGTCCCGGCCTCGGGGTGCGCATCCTGGGCGAAGTCAAAAAAGAGTA
CGCTGACCTGCTGCGCCGCGCCGACGCCATCTTTATCGAAGAACTGCGCAACTTCAGGGATGCCGAGACCGGCAAGACCT
GGTACGACCTGACCAGCCAGGCGTTCACCGTCTTCCTGCCGGTGAAAAGCGTGGGTGTGATGGGCGATGGCCGCACCTAT
GACTATGTGGTGGCGCTGCGCGCTGTGCAAACCAGCGACTTCATGACCGCAGACTGGGCAGAACTGCCCTACGCGTTGCT
CAAAAAGGTCTCCAGCCGCATCATCAACGAGGTGCGCGGCATCAACCGCGTCACTTACGACGTGAGCAGCAAGCCGCCGG
CAACGATCGAGTGGGAATAA

Protein sequence :
MQHQKILILDFGSQVTQLIARRVRDAHVFCEVHPCDVTDDWVRDYARDGTLKGVILSGSHASIYEETTDKAPQAVFELGL
PVLGICYGMQAMAHQLGGKVEGGHKREFGSADVRARGHTALLKDIADYTTPEGQGMLDVWMSHGDKVTEMPPGFKLMAST
ESCPIAGMADEDRRFYAVQFHPEVTHTKQGNAILKRFVLDICGTRQDWVMGDYISEAVEKIRQQVGDEEVILGLSGGVDS
SVAAALIHRAIGDQLTCVFVDHGLLRLNEGDMVMDMFVGKLHARVVRVDASEQFLGHLAGVSEPEAKRKIIGREFVEVFK
AEAARLKAGDGGHKGAKWLAQGTIYPDVIESGGAKSKKAVTIKSHHNVGGLPEQLGLKLLEPLRELFKDEVRELGVALGL
PHDMVYRHPFPGPGLGVRILGEVKKEYADLLRRADAIFIEELRNFRDAETGKTWYDLTSQAFTVFLPVKSVGVMGDGRTY
DYVVALRAVQTSDFMTADWAELPYALLKKVSSRIINEVRGINRVTYDVSSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 4e-116 50
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-116 50
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 4e-116 50
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-105 48