Gene Information

Name : guaA (Mfla_1139)
Accession : YP_545248.1
Strain : Methylobacillus flagellatus KT
Genome accession: NC_007947
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1187757 - 1189337 bp
Length : 1581 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCAACAAAAAATTCTGATTCTCGATTTCGGCTCCCAATACACCCAGCTGATCGCCCGTCGCATCCGTGAGGCCAACGT
CTACTGTGAGCTGCACTCATGGGACGTATCTGATGCATTCATCCGCGAGTTCAACCCAGCAGGCGTGATCCTCTCCGGCG
GCCCCAACTCTGTCTATGAAGACGAAACCCCGCGTGCGCCGCAAAGCGTGTTCGAACTGGGTGTGCCCGTATTGGGCATC
TGCTATGGCATGCAGACCATGGCAGCGCAACTTGGCGGCTCGGTGGAAAATGCCGCCAAGCGCGAGTTCGGCTACGCCGA
AATCCGCGCCCAGGGACACTCCGCCCTGCTAAAAGGCATTCAGGACAAAAGCAATGCAGAAGGCCACGGCTTGCTGGACG
TCTGGATGAGCCATGGCGACAAGGTCACGGCCTTGCCCGAGGGCTTCAAGATCATTGCCAGCAACAGCGCAACCCCGATT
GCCGGCATGGCGGACGAAAACCGCCGCTTCTACGCGGTACAGTTCCATCCTGAAGTCACCCATACCAAGCAAGGCAAAGC
CCTGCTCAACCGCTTCGTGCACGACATCTGCGGTTGCGACCAGAGCTGGAACATGCCGGACTATGTGGAAACCGCCGTGC
AACGCATCCGCGAGGAAGTCGGCTGCGATGAAGTCATCCTCGGTCTTTCCGGCGGCGTGGATTCCTCAGTGGCTGCCGCG
CTGATTCATCGCGCGATTGGCGACCAACTCACCTGCGTCTTCGTCGACAACGGTCTGTTGCGCCTCAACGAAGCCGAGCA
GGTGATGGAAACCTTCGGCAAGAACCTCGGCGTCAAGGTCATCCATGTCGATGCCAGCGCCAAATTCCTCGGCGACCTCT
CAGGTGTGAACGATCCGGAAGCCAAGCGCAAGATCATCGGCCGTGAGTTCGTGGAAGTGTTCCAGCAGGAAGCTGCCAAG
CTGCCGCAAGCCAAGTGGCTGGCACAGGGCACCATCTACCCCGATGTCATCGAGTCCGCCGGCGCCAAGACCAAGAAGGC
CCATACCATCAAGAGCCACCACAACGTAGGTGGCCTGCCCGATACGCTGAAACTCAAGCTACTCGAACCATTGCGTGAAC
TGTTCAAGGATGAAGTCCGCGAGCTTGGCATTGCCCTCGGTCTGCCGCACGACATGGTCTACCGCCACCCCTTCCCCGGC
CCCGGCCTCGGAGTGCGCATACTGGGTGAGGTCAAGCGCGAATACGCCGACCTGCTGCGCCAGGCCGACCATATTTTCAT
TGAGGAGCTGCGCAGCACCAAGGATGCGGACGGCAAGTCATGGTACGACAAGACCTCGCAAGCCTTTGCCGTGTTCTTGC
CAGTGAAATCCGTGGGCGTAATGGGCGATGGCCGCACCTATGACTATGTGGTCGCCCTGCGCGCTGTGGTCACCACCGAC
TTCATGACCGCGCACTGGGCCGAGCTGCCTTACGACCTGCTGGGCAAGGTGTCCAACCGTATCATCAATGAAGTGCGCGG
CATCAACCGCGTGGTGTACGACATCTCGGGCAAGCCACCAGCCACAATCGAGTGGGAGTGA

Protein sequence :
MQQKILILDFGSQYTQLIARRIREANVYCELHSWDVSDAFIREFNPAGVILSGGPNSVYEDETPRAPQSVFELGVPVLGI
CYGMQTMAAQLGGSVENAAKREFGYAEIRAQGHSALLKGIQDKSNAEGHGLLDVWMSHGDKVTALPEGFKIIASNSATPI
AGMADENRRFYAVQFHPEVTHTKQGKALLNRFVHDICGCDQSWNMPDYVETAVQRIREEVGCDEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDNGLLRLNEAEQVMETFGKNLGVKVIHVDASAKFLGDLSGVNDPEAKRKIIGREFVEVFQQEAAK
LPQAKWLAQGTIYPDVIESAGAKTKKAHTIKSHHNVGGLPDTLKLKLLEPLRELFKDEVRELGIALGLPHDMVYRHPFPG
PGLGVRILGEVKREYADLLRQADHIFIEELRSTKDADGKSWYDKTSQAFAVFLPVKSVGVMGDGRTYDYVVALRAVVTTD
FMTAHWAELPYDLLGKVSNRIINEVRGINRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-126 52
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-126 52
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-126 52
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-112 49