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Name : LSL_0035 (LSL_0035) Accession : YP_534941.1 Strain : Lactobacillus salivarius UCC118 Genome accession: NC_007929 Putative virulence/resistance : Virulence Product : two-component response regulator Function : - COG functional category : T : Signal transduction mechanisms COG ID : COG0745 EC number : - Position : 43139 - 43849 bp Length : 711 bp Strand : + Note : COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain DNA sequence : ATGAAAAAGATACTTGTAGTAGATGATGAAAAACCCATCTCAGATATCGTGAAATTTAATTTAACCAAAGAAGGTTATGA TGTTTATACAGCCTATGATGGTGAAGAAGCTTTACAACAAGTTAAAGAAGTAGAACCAGACTTGATTTTACTTGACTTGA TGTTGCCAAAAATTGATGGCTTAGAAGTAGCTCGTGAAGTTCGTAAGACACATGACATGCCAATCATTATGGTAACAGCC AAGGATTCTGAAATTGATAAGGTTCTAGGTTTGGAATTAGGTGCAGATGACTATGTAACTAAACCTTTCTCTAACCGTGA ATTAGTAGCTCGTGTTAAGGCTAATTTACGCCGTCAATCAGCAGTAGCCGCAAAGTCTTCTGCTGAAGATGACAAGAATT CTGAAATTACTGTTGGTGATTTGACAATTCATCCAGAAGCATACACTGTATCTAAGAATGGTCAAAGAATTGAATTAACT CATCGCGAATTTGAGTTATTACATTACTTAGCTCAACATCTAGGTCAAGTTATGACGCGTGAACATTTGTTACAAACAGT TTGGGGATATGACTACTTTGGTGATGTGCGTACTGTGGACGTAACAGTTCGTCGTTTAAGAGAAAAGATTGAAGATAATC CTAGTCGTCCAACTTGGTTAGTGACACGTCGTGGTGTAGGTTATTATTTACGCAATCCTGAAGTTGAATAG Protein sequence : MKKILVVDDEKPISDIVKFNLTKEGYDVYTAYDGEEALQQVKEVEPDLILLDLMLPKIDGLEVAREVRKTHDMPIIMVTA KDSEIDKVLGLELGADDYVTKPFSNRELVARVKANLRRQSAVAAKSSAEDDKNSEITVGDLTIHPEAYTVSKNGQRIELT HREFELLHYLAQHLGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSRPTWLVTRRGVGYYLRNPEVE |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| c3565 | NP_755440.1 | response regulator | Not tested | PAI I CFT073 | Protein | 7e-33 | 42 |
| unnamed | CAD42044.1 | hypothetical protein | Not tested | PAI II 536 | Protein | 9e-33 | 41 |
| kdpE | YP_039536.1 | response regulator protein | Not tested | Type-II SCCmec | Protein | 4e-24 | 41 |
| kdpE | NP_370594.1 | transcriptional regulator kdpE | Not tested | Type-II SCCmec | Protein | 4e-24 | 41 |
| kdpE | NP_373306.1 | hypothetical protein | Not tested | Type-II SCCmec | Protein | 4e-24 | 41 |
| kdeP | YP_190033.1 | DNA-binding response regulator KdeP | Not tested | Type-II SCCmec | Protein | 4e-24 | 41 |
| SH0031 | YP_251946.1 | hypothetical protein | Not tested | SCCmec | Protein | 1e-24 | 41 |
| kdpE | BAA82188.1 | KDP operon transcriptional regulatory protein KdpE | Not tested | Type-II SCCmec | Protein | 3e-24 | 41 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_012469.1.7685629. | Protein | 3e-71 | 70 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_003923.1003749.p0 | Protein | 2e-52 | 53 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_002952.2859905.p0 | Protein | 1e-52 | 52 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_009641.5332272.p0 | Protein | 2e-52 | 52 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_013450.8614421.p0 | Protein | 2e-52 | 52 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_007793.3914279.p0 | Protein | 2e-52 | 52 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_007622.3794472.p0 | Protein | 1e-52 | 52 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_002745.1124361.p0 | Protein | 2e-52 | 52 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_009782.5559369.p0 | Protein | 2e-52 | 52 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_002951.3237708.p0 | Protein | 2e-52 | 52 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_002758.1121668.p0 | Protein | 2e-52 | 52 |
| LSL_0035 | YP_534941.1 | two-component response regulator | HE999704.1.gene2815. | Protein | 4e-46 | 50 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_012469.1.7686381. | Protein | 7e-40 | 49 |
| LSL_0035 | YP_534941.1 | two-component response regulator | AE016830.1.gene1681. | Protein | 3e-46 | 47 |
| LSL_0035 | YP_534941.1 | two-component response regulator | AF155139.2.orf0.gene | Protein | 2e-37 | 46 |
| LSL_0035 | YP_534941.1 | two-component response regulator | FJ349556.1.orf0.gene | Protein | 3e-39 | 46 |
| LSL_0035 | YP_534941.1 | two-component response regulator | CP000034.1.gene3834. | Protein | 2e-34 | 45 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_002695.1.915041.p | Protein | 2e-34 | 45 |
| LSL_0035 | YP_534941.1 | two-component response regulator | CP001918.1.gene5135. | Protein | 8e-30 | 45 |
| LSL_0035 | YP_534941.1 | two-component response regulator | AE000516.2.gene3505. | Protein | 3e-36 | 45 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_013450.8614146.p0 | Protein | 6e-37 | 45 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_002951.3238224.p0 | Protein | 6e-37 | 45 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_007793.3914065.p0 | Protein | 6e-37 | 45 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_002758.1121390.p0 | Protein | 6e-37 | 45 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_010079.5776364.p0 | Protein | 6e-37 | 45 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_002952.2859858.p0 | Protein | 6e-37 | 45 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_007622.3794948.p0 | Protein | 6e-37 | 45 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_003923.1003417.p0 | Protein | 6e-37 | 45 |
| LSL_0035 | YP_534941.1 | two-component response regulator | CP000647.1.gene4257. | Protein | 1e-34 | 44 |
| LSL_0035 | YP_534941.1 | two-component response regulator | CP001138.1.gene4273. | Protein | 1e-34 | 44 |
| LSL_0035 | YP_534941.1 | two-component response regulator | BAC0533 | Protein | 1e-34 | 44 |
| LSL_0035 | YP_534941.1 | two-component response regulator | AF162694.1.orf4.gene | Protein | 4e-34 | 43 |
| LSL_0035 | YP_534941.1 | two-component response regulator | CP004022.1.gene3215. | Protein | 8e-37 | 43 |
| LSL_0035 | YP_534941.1 | two-component response regulator | AM180355.1.gene1830. | Protein | 5e-38 | 43 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_002695.1.916589.p | Protein | 3e-31 | 43 |
| LSL_0035 | YP_534941.1 | two-component response regulator | BAC0039 | Protein | 2e-31 | 43 |
| LSL_0035 | YP_534941.1 | two-component response regulator | CP001138.1.gene2239. | Protein | 2e-30 | 43 |
| LSL_0035 | YP_534941.1 | two-component response regulator | CP000034.1.gene2186. | Protein | 2e-31 | 43 |
| LSL_0035 | YP_534941.1 | two-component response regulator | BAC0596 | Protein | 2e-30 | 43 |
| LSL_0035 | YP_534941.1 | two-component response regulator | AF130997.1.orf0.gene | Protein | 2e-36 | 42 |
| LSL_0035 | YP_534941.1 | two-component response regulator | CP000647.1.gene2531. | Protein | 1e-29 | 42 |
| LSL_0035 | YP_534941.1 | two-component response regulator | HE999704.1.gene1528. | Protein | 3e-30 | 41 |
| LSL_0035 | YP_534941.1 | two-component response regulator | CP001485.1.gene721.p | Protein | 8e-29 | 41 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_014475.1.orf0.gen | Protein | 5e-37 | 41 |
| LSL_0035 | YP_534941.1 | two-component response regulator | NC_005054.2598277.p0 | Protein | 5e-37 | 41 |
| LSL_0035 | YP_534941.1 | two-component response regulator | EU250284.1.orf4.gene | Protein | 3e-35 | 41 |
| LSL_0035 | YP_534941.1 | two-component response regulator | AE015929.1.gene1106. | Protein | 1e-30 | 41 |
| LSL_0035 | YP_534941.1 | two-component response regulator | CP004022.1.gene1676. | Protein | 3e-26 | 41 |
| LSL_0035 | YP_534941.1 | two-component response regulator | CP001918.1.gene3444. | Protein | 8e-30 | 41 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| LSL_0035 | YP_534941.1 | two-component response regulator | VFG1389 | Protein | 6e-31 | 45 |
| LSL_0035 | YP_534941.1 | two-component response regulator | VFG1702 | Protein | 3e-33 | 42 |
| LSL_0035 | YP_534941.1 | two-component response regulator | VFG1386 | Protein | 6e-35 | 42 |
| LSL_0035 | YP_534941.1 | two-component response regulator | VFG1563 | Protein | 5e-33 | 41 |
