Gene Information

Name : metC (LSL_0027)
Accession : YP_534933.1
Strain : Lactobacillus salivarius UCC118
Genome accession: NC_007929
Putative virulence/resistance : Resistance
Product : cystathionine beta-lyase / cystathionine gamma-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.8
Position : 32755 - 33897 bp
Length : 1143 bp
Strand : +
Note : COG0626 [E] Cystathionine beta-lyases/cystathionine gamma-synthases

DNA sequence : 
ATGAAATTTGAAACAAAATTAATTCATGGCGGACAAAGTGAAGATCAAGCAACAGGAGCAGTATCAATCTCTGTATATCG
TTCATCAACATTCCATCAATATGAGTTGGGTGGTAATCCTAAGTGGGAATACAGTCGTACAGGAAATCCTACACGTGCAG
CCTTAGAAGCGTTGATTGCTGATTTGGAAGGTGGGGTAGCTGGATTTGCCTTTGCTTCAGGTTCAGCAGCAATTCATGCT
ACATTCTCTATGTATTCAGCTCATGATCATTTTATCGTAGGAAGCGACGTTTATGGTGGAACTTTCCGTTTGATAAATAA
AGTGTTGAAACGATTTGGTTTAGAATTTACAGTTGTTGATATACAAGATTTGGCAGCAGTTGAAAATGCAATTCAAGATA
ACACAGTGGCAATCTACTTTGAAACACCAACAAATCCTTTGTTACAGATTGCAGATATTGCAGCTATTACAAAGATTGCT
AAGAAACATAAGTTAAAGACAATCGTTGATAATACTTTCGCAACTCCATACAATCAAAGACCACTTGAATTAGGTGCTGA
TATTGTGGTCCATTCGGCTACTAAATATTTAGGTGGACATAGCGATGTAGTAGCAGGTTTAGCAGTTACTAGCGATGAAA
AAATTGCAGAAAAACTAGCATTTCTACAAAATTCAATCGGTAGTACATTAGGACCAGATGATAGCTGGTTGATTCAAAGA
GGAATTAAGACATTAGGTGCTAGAATGAGAGTTCATCATGCTAATACCGAAGCTATAATTAAGTTTTTAGAAAATGATGA
TCGCGTTGCAAGAATTCTCTATCCTGGTTTGCCTGACTTTCCTGGACATGAAGTGGCTAAGAAACAAATGGATCACTTTG
GAGCGATGATTTCTTTTGAATTACAAGAAGGATTAGATACTAAAAAGTTTGTTGAAAGTTTGAAAGTAATTTCTCTTGCA
GAAAGTCTAGGTGGGATTGAAAGTTTAATTGAAGTTCCATCAGTAATGACACATGGTTCAATTCCTAGAGAAATTCGTTT
AGAAAATGGAATTAAAGATGAATTGATTCGTTTGTCAGTAGGAATTGAAGATGAAGAAGACTTGATTAATGATTTGAAAC
AAGCTTTAGATAAAATTGGATAA

Protein sequence : 
MKFETKLIHGGQSEDQATGAVSISVYRSSTFHQYELGGNPKWEYSRTGNPTRAALEALIADLEGGVAGFAFASGSAAIHA
TFSMYSAHDHFIVGSDVYGGTFRLINKVLKRFGLEFTVVDIQDLAAVENAIQDNTVAIYFETPTNPLLQIADIAAITKIA
KKHKLKTIVDNTFATPYNQRPLELGADIVVHSATKYLGGHSDVVAGLAVTSDEKIAEKLAFLQNSIGSTLGPDDSWLIQR
GIKTLGARMRVHHANTEAIIKFLENDDRVARILYPGLPDFPGHEVAKKQMDHFGAMISFELQEGLDTKKFVESLKVISLA
ESLGGIESLIEVPSVMTHGSIPREIRLENGIKDELIRLSVGIEDEEDLINDLKQALDKIG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 6e-76 51
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 4e-77 51
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 6e-60 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metC YP_534933.1 cystathionine beta-lyase / cystathionine gamma-lyase BAC0207 Protein 1e-60 45