Gene Information

Name : ureC (RPC_3692)
Accession : YP_533546.1
Strain : Rhodopseudomonas palustris BisB18
Genome accession: NC_007925
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 4115334 - 4117046 bp
Length : 1713 bp
Strand : -
Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp

DNA sequence :
ATGTCCGTGAAAATTCCGCGCTCCGTCTATGCCGACATGTTCGGCCCCACCACCGGCGATCGGGTGCGGCTCGCCGACAC
CGATCTGATCATCGAGGTGGAGAAGGACTTCACGATCTACGGCGAGGAGGTGAAGTTCGGCGGCGGCAAGGTGATCCGCG
ACGGCATGGGGCAGAGCCAGGTGACCAACGCGCAAGGCGCCGCCGACACCGTGATCACCAACGCGCTGATCGTCGATCAT
TGGGGCATCGTCAAAGCCGACGTCGCCTTGAAGGACGGATACATCGCCGCCATCGGCAAGGCCGGCAATCCGGACATCCA
GCCCGGCGTCACCATCATCATCGGTCCCGGCACCGACATCATCGCCGGCGAGGGCAAGATCCTCACCGCCGGCGGCTTCG
ACAGCCACATCCATTTCATCTGCCCGCAGCAGATCGAGCACGCGCTGATGAGCGGCGTCACCTCGATGCTCGGCGGCGGC
ACCGGCCCGTCGCACGGCACCTTCGCCACCACCTGCACGCCGGGGCCGTGGCACCTCGGCCGGATGATCCAGTCGTTCGA
CGCCTTTCCGGTCAATCTCGGGCTGGCCGGCAAGGGCAACGCCTCGCAGCCCGCGGCGCTGAAGGAGATGATCGAGGCCG
GCGCCTGCGCGCTGAAACTGCACGAGGACTGGGGCACCACGCCGGCGGCGATCGACAATTGCCTCACCGTCGCCGACGAC
TACGACGTCCAGGTGATGATCCATTCCGATACGCTGAACGAGTCCGGCTTCGTCGAGGACACCATCAAGGCATTCAAGGG
CCGCACCATCCACGCCTTCCACACCGAGGGCGCCGGCGGCGGCCATGCGCCGGATATCATCAAGGTGGCGGGGCTGCCCA
ACGTGTTGCCGTCGTCGACCAACCCGACCCGGCCGTTCACCAAGAACACCATCGACGAGCATCTCGACATGCTGATGGTG
TGTCACCATCTCGATCCGTCGATCGCCGAGGATCTGGCGTTCGCCGAAAGCCGGATCCGCAAGGAGACCATCGCGGCGGA
GGACATTCTCCACGACCTCGGCGCGCTGTCGATGATGTCGTCGGATAGTCAAGCCATGGGCCGGCTCGGCGAGGTGATCA
TCCGCACCTGGCAGACCGCCGACAAGATGAAGAAGCAGCGCGGATCATTGCCGCAGGACTCGGCGCGCAACGACAATTTC
CGGGTCAAGCGCTACATCGCCAAATACACTATCAATCCGGCGATCGCGCACGGCGTGGCGCGGCTGATCGGCTCGATCGA
GCAGGGCAAGCTCGCCGATCTGGTGCTGTGGTCGCCGGCGTTCTTCGGCGTCAAGCCGGACCTGATCATCAAGGGTGGCT
CGATCGTGGCGGCGCCGATGGGCGATCCGAATGCGTCGATCCCCACCCCGCAGCCGGTGCATTATCAGCCGATGTTCGCC
GCCTACGGCCGCTCGCTGTTCGCCTCCTCGGTGGTGTTCACCTCGCAGGCCGCGGTGGCGGAAGGGTTGGCGAAGAAGCT
CGGCATTCAGAAATCGCTCTACGGGGTGGAGAACACCCGCTCCGGCATCTCCAAGAAGAGCATGATCCACAACGACGCCA
CGCCGAATATCGAGGTCGATCCGGAGACCTACGAGGTCCGCGCCGATGGCGAATTGTTGACCTGCGCACCGGCCGAGGTG
CTGCCGATGGCGCAACGCTATTTCATGTATTGA

Protein sequence :
MSVKIPRSVYADMFGPTTGDRVRLADTDLIIEVEKDFTIYGEEVKFGGGKVIRDGMGQSQVTNAQGAADTVITNALIVDH
WGIVKADVALKDGYIAAIGKAGNPDIQPGVTIIIGPGTDIIAGEGKILTAGGFDSHIHFICPQQIEHALMSGVTSMLGGG
TGPSHGTFATTCTPGPWHLGRMIQSFDAFPVNLGLAGKGNASQPAALKEMIEAGACALKLHEDWGTTPAAIDNCLTVADD
YDVQVMIHSDTLNESGFVEDTIKAFKGRTIHAFHTEGAGGGHAPDIIKVAGLPNVLPSSTNPTRPFTKNTIDEHLDMLMV
CHHLDPSIAEDLAFAESRIRKETIAAEDILHDLGALSMMSSDSQAMGRLGEVIIRTWQTADKMKKQRGSLPQDSARNDNF
RVKRYIAKYTINPAIAHGVARLIGSIEQGKLADLVLWSPAFFGVKPDLIIKGGSIVAAPMGDPNASIPTPQPVHYQPMFA
AYGRSLFASSVVFTSQAAVAEGLAKKLGIQKSLYGVENTRSGISKKSMIHNDATPNIEVDPETYEVRADGELLTCAPAEV
LPMAQRYFMY

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 0.0 69
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 0.0 69
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-162 62
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 6e-163 62
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 6e-163 62
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 6e-163 62

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC YP_533546.1 urease subunit alpha VFG0270 Protein 1e-160 62