|
Name : ureC (Rfer_3402) Accession : YP_524642.1 Strain : Rhodoferax ferrireducens T118 Genome accession: NC_007908 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 3787288 - 3789033 bp Length : 1746 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGGCAACCATCGGACGGCGCGCTTACGCTGAAATGTTTGGCCCCACGGTGGGCGACCGGGTGCGCCTGGCCGACACCAA CCTGATCATTGAAGTCGAAGACGACTACACCCTGCGCGCGGGCGGCTACGGCGAAGAAGTCAAGTTTGGCGGCGGCAAAA CCATCCGCGATGGCATGGCGCAGTCGCAGCGCAGCCGGGCCGAGGGCGCGGTTGATACCGTCATGACAAATGCCCTGATC ATTGACCACTGGGGCATTGTCAAGGCCGACATTGGCCTCAAAGACAGCCGCATCGTGGCCATCGGCAAAGCCGGCAACCC AGACACCCAGCCGGGCGTGGACATCATCATCGGCCCGGGCACCGAAGTCATCAGCTGCGAAGGCAGCATCGTCACCGCCG GTGGTTTTGACAGCCACATCCACTTCATTTGCCCGCAACTGATTGAAGAGGCTTTGAGTAGCGGAATCACCACCATGACC GGCGGCGGCACGGGCCCGGCCACCGGCACCTTTGCCACCACCTGCACACCCGGCTCGTGGCACATTGAGCGCATGCTGCA GGCCGCTGATGCGTTTGCCATGAACCTGGGCTTCATGGGCAAGGGCAACGCCAGCCTGCCTGCCGCGCTGCACGAGCAAA TCAACGCGGGCGCCTTGGGCCTCAAATTACACGAAGACTGGGGCACCACGCCAGCGGCGATCGACAACTGCCTGAACGTG GCCGAACTCACCGACACACAGGTGGCGATCCACACCGACACGCTCAACGAATCGGGCTTTGTGGAAGACACACTGGCCGC TTTCAAAGGTCGCAGCATCCACACCTTTCACACCGAAGGGGCTGGCGGCGGCCACGCGCCTGACATCATGAAACTGGTGG GCGAGCCCAACGTGCTGCCGTCTTCCACCAACCCGACACGGCCGTACACCGTCAACACGCTGGATGAACACGTGGACATG CTGATGGTCTGCCACCACCTGGACGCCGCCATAGCCGAAGACCTGGCCTTTGCCGAGAGCCGCATCCGCAAGGAAACCAT CGCCGCCGAAGACATCCTGCACGACCTGGGCGCCATCAGCATCATGAGCAGCGACAGCCAGGCCATGGGCCGCGTCGGTG AGGTCATCATCCGTACCTGGCAGACCGCGCACAAGATGAAGGCGCAGCGCGGCTGGCTGGCACCGCCGCCTGAGCGCAGC GAGCCGGTGGAAAAATTGCAGCGCAACGACAACTACCGGGTCAAGCGCTACCTGGCCAAGTACACGATCAACCCGGCACT GACGCACGGCATGGCGCATGAAGTGGGCTCCATCGAGCTTGGCAAATGGGCCGATCTGGTGGTCTGGAGGCCCGCCTTCT TTGGCGTCAAACCGTCCTTGATTGTCAAAGGCGGCTCAATCGCCATGGCGGCCATGGGCGACCCCAATGCCAGCATCCCG ACGCCGCAACCGGTGCATTACCGGCCCATGTTTGGCGCGTTTGGCGGCGCCTTGGCGCGCGGCTCGCTCACCTTTGTATC GCAAGCCGGGTTGAACGCCGGTATTGGCGCGCGCTATGGGCTGAGCAAGACTTTAAGCGCCGTCAAAAACATCCGGGGCA TTCGCAAAGAGCACATGGTGCATAACCACTACCTGCCCAAGATGGAGATCGATGCCCAGACCTACAGCGTGCGCGCCGAC GGCGAGTTGCTCACCTGCGAGCCGGCGGTGAGTTTGCCGATGACGCAGCGCTACTTTTTGTTCTAA Protein sequence : MATIGRRAYAEMFGPTVGDRVRLADTNLIIEVEDDYTLRAGGYGEEVKFGGGKTIRDGMAQSQRSRAEGAVDTVMTNALI IDHWGIVKADIGLKDSRIVAIGKAGNPDTQPGVDIIIGPGTEVISCEGSIVTAGGFDSHIHFICPQLIEEALSSGITTMT GGGTGPATGTFATTCTPGSWHIERMLQAADAFAMNLGFMGKGNASLPAALHEQINAGALGLKLHEDWGTTPAAIDNCLNV AELTDTQVAIHTDTLNESGFVEDTLAAFKGRSIHTFHTEGAGGGHAPDIMKLVGEPNVLPSSTNPTRPYTVNTLDEHVDM LMVCHHLDAAIAEDLAFAESRIRKETIAAEDILHDLGAISIMSSDSQAMGRVGEVIIRTWQTAHKMKAQRGWLAPPPERS EPVEKLQRNDNYRVKRYLAKYTINPALTHGMAHEVGSIELGKWADLVVWRPAFFGVKPSLIVKGGSIAMAAMGDPNASIP TPQPVHYRPMFGAFGGALARGSLTFVSQAGLNAGIGARYGLSKTLSAVKNIRGIRKEHMVHNHYLPKMEIDAQTYSVRAD GELLTCEPAVSLPMTQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 1e-163 | 69 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 1e-163 | 69 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-148 | 60 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-148 | 60 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 1e-148 | 60 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-148 | 60 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_524642.1 | urease subunit alpha | VFG0270 | Protein | 1e-137 | 58 |
