Gene Information

Name : vanB (DSY3690)
Accession : YP_519923.1
Strain : Desulfitobacterium hafniense Y51
Genome accession: NC_007907
Putative virulence/resistance : Resistance
Product : D-alanine--D-lactate ligase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1181
EC number : -
Position : 4202890 - 4203951 bp
Length : 1062 bp
Strand : -
Note : vancomycin B-type resistance protein; catalyzes the formation of D-alanyl-D-lactate in peptidoglycan synthesis

DNA sequence :
ATGGATCGGTTGAAAATCGCAATTATTTTCGGAGGCTGTTCCGAAGAACATCCCGTCTCCGTTAAATCGGCTGGGGAGGT
TGCCAAAAACCTGGATCTCGATAAGTATGAACCCTTCTATATCGGGATTACGAAAAATGGGGTTTGGCAGCTTTGCCGCT
ACCCTGAGGCCAATTGGGAAAACGGCATTTGCCCTTCGGTTATCCTGTCACCGGACAGAAGCCTCCAGGGATTGCTTGTT
CTGGAGCAGGGACAATATAAAACGATTCCTTTGGATCTGGTGTTTCCCGTTCTGCATGGTAAATTTGGCGAGGATGGGGC
GGTGCAAGGTTTGTTGGAGCTCTCCGGCATCCCCTATGTGGGCTGCGATATCCCCAGTTCGGCCTTGTGCATGGACAAAT
CCCTTGCTTATATCGTCGCCGGAAACGCAGGAATTGCCACGCCAAAGTTCCGGACGGTCACGGCGAAAGAGGCCATTGAT
GCCGAACGGCTTGCTTATCCCGTTTATGTCAAGCCGGCCCGTTCGGGTTCATCCTTCGGCGTCACTAAAGTATGCCGCCA
AGAAGAATTGCTGAGTGCGGTGGCAATCGCCAGCCAGTATGACTCGAAGGTGCTGATTGAAGAGGCTGTCATCGGCACTG
AGGTAGGGTGTGCAATATTTGGCAACGATCTGGATTTAATGGCCGGGGAGGTCGATCAGATTCGCCTGTCTCACGGCTTT
TTCAGAATCCATCAGGAGAATGAGCCGGAAAAGGGTTCCGAAAACTCAACCCTAATCGTTCCCGCCGACATTTCGCCGCA
GGCGCGTTCGCGGGTTCAGGAGACGGCAAAAGCCATCTATCGCGCTTTGGGATGCAAGGGACTGGCACGGGTGGATATGT
TCCTGAAGGAAGATGGAGAAGTAATCCTGAACGAGGTGAATACTTTGCCCGGTATGACCTCGTACAGCCGTTTTCCGAGG
ATGATGGCGGCCGCAGGCTTGCCCTTTGCCGAAGTGATCGACCGGCTTGTCTCGTTGGCCTTGCAAGGAAAAACAGGAGC
CTTATCCCAACACTTACTTTAA

Protein sequence :
MDRLKIAIIFGGCSEEHPVSVKSAGEVAKNLDLDKYEPFYIGITKNGVWQLCRYPEANWENGICPSVILSPDRSLQGLLV
LEQGQYKTIPLDLVFPVLHGKFGEDGAVQGLLELSGIPYVGCDIPSSALCMDKSLAYIVAGNAGIATPKFRTVTAKEAID
AERLAYPVYVKPARSGSSFGVTKVCRQEELLSAVAIASQYDSKVLIEEAVIGTEVGCAIFGNDLDLMAGEVDQIRLSHGF
FRIHQENEPEKGSENSTLIVPADISPQARSRVQETAKAIYRALGCKGLARVDMFLKEDGEVILNEVNTLPGMTSYSRFPR
MMAAAGLPFAEVIDRLVSLALQGKTGALSQHLL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
vanB NP_815951.1 D-alanine--D-lactate ligase Not tested Not named Protein 2e-109 66
vanB YP_008394259.1 Vancomycin B-type resistance protein vanB, D-alanine--D-lactate ligase Not tested Not named Protein 3e-111 66

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
vanB YP_519923.1 D-alanine--D-lactate ligase U00456.gene.p01 Protein 1e-109 66
vanB YP_519923.1 D-alanine--D-lactate ligase AF310956.2.orf5.gene Protein 3e-110 66
vanB YP_519923.1 D-alanine--D-lactate ligase U35369.1.gene6.p01 Protein 1e-109 66
vanB YP_519923.1 D-alanine--D-lactate ligase AE016830.1.gene2250. Protein 1e-109 66
vanB YP_519923.1 D-alanine--D-lactate ligase AY145441.gene.p01 Protein 2e-110 66
vanB YP_519923.1 D-alanine--D-lactate ligase NC_014475.1.orf3.gen Protein 3e-109 65
vanB YP_519923.1 D-alanine--D-lactate ligase NC_005054.2598280.p0 Protein 3e-109 65
vanB YP_519923.1 D-alanine--D-lactate ligase AF277571.gene.p01 Protein 3e-112 64
vanB YP_519923.1 D-alanine--D-lactate ligase AY489045.gene.p01 Protein 2e-109 64
vanB YP_519923.1 D-alanine--D-lactate ligase AF130997.1.orf4.gene Protein 2e-109 63