Gene Information

Name : guaA (CF0428)
Accession : YP_515345.1
Strain : Chlamydophila felis Fe/C-56
Genome accession: NC_007899
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 502180 - 503718 bp
Length : 1539 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
TTGAGTAAGATTCTTATTCTTGATTTTGGCTCTCAATATACGAATGTTTTAGCCAAAAAGATACGCTTACTTTCCGTATT
TTGTGAGGTACTTCCTTGGAATACACCTCTAGAAGACATTCTTCAAGAGTCTCCTTCAGGTCTAATTTTTTCTGGAGGGC
CTCATTCTGTTTATCAGGAGAATAGTCCAAAAGTTGATAGAGAAATCTATAACGCTAACATCCCTATACTTGGGGTATGT
TATGGTATGCAACTTATCGCTAGAGATTTTGGAAGTGAGGTAAGGGGAGGAGAGAATGAGTTTGGCTATACCCCTATAGT
TTTTTATCCGGGAAAACTTTTTCAAGGCCTTGTGGATAAGGACGCTTTTCATACTGAAATTCGTATGAGTCATTGCGACT
CTGTTACAGTCCCTCCTAAAGATTTTTTCATTACTGCAAGTTCACAACATTGTCCTGTTGCAGCCATAGAATACCCTGAG
AAAAAACTTTTCGGTCTCCAATTTCATCCGGAAGTTTCAGATTCTCAAGGAATAGGTGATACAATTTTATCAAATTTTGT
TAAGCATATCTGTCGGGCTTCGGAAACTTGGAAAATTGAGACAATAGAAAAACAACTTATTCAAAGGATCAAAGAACAAG
TAGGAGAAAAGGAACGTGTATTACTAGGCTTGTCTGGAGGGGTAGACTCTTCTGTTTTAGCTGTTTTACTTCATAATGCC
TTGGGTGATCGTTTATCGTGTGTCTTTGTTGATACGGGGCTATTGAGGAAAAATGAAGTTGAAGAGGTTAAACAGCAATT
TTTATCTCTAGGGCTAGAGATAATAGTGGAAGATGCTTCTGAAACATTTTTCTACGAGTTATCCGGAATACAGGATCCCG
AACAGAAACGTAAAATCATTGGATCTACCTTTATTGAAGTTTTTGATAAAGTATCTAAAAACCTTGAGGTTCAGTGGTTG
GCTCAAGGAACTATTTATTCCGATGTTATTGAATCGGCAAAATCTTGTGATGCAACGCAAGTAATTAAATCTCACCATAA
TGTTGGCGGACTTCCAGAAAAATTAAATCTGAAACTTTTAGAACCTTTGCGTTTTCTTTTTAAGGATGAAGTTAGAGCTT
TGGGCAAAGTTTTGGGCTTACCAGAAGTCTTTATATCCCGACACCCCTTTCCTGGCCCTGGTTTAGGAGTCAGAGTTCTT
GGAGAAATCCGTAAAGAATATGTAGAAATAGTAAAACATGCTGATAGTATCTTTATTGAAGAACTAAAAAAAGCTAATTT
ATACGACAAGGTTAGCCAAGCATTTGCTGTTTTCTTACCAGTAAAGTCGGTTGCTGTAAAAGGGGATTGTCGTCATTATG
GCTATACGATAGCTTTACGTGCAGTAGAGTCTTCTGATTTCATGACAGCATGCTGGTCGCCCCTATCTAGAGAATTTCTT
AACCGTTGTTCATCACGCATTATTAACGAAATCCCAGAAGTTAGCAGAGTGGTTTACGATATTTCCGATAAACCTCCAGC
AACTATTGAATGGGAATAG

Protein sequence :
MSKILILDFGSQYTNVLAKKIRLLSVFCEVLPWNTPLEDILQESPSGLIFSGGPHSVYQENSPKVDREIYNANIPILGVC
YGMQLIARDFGSEVRGGENEFGYTPIVFYPGKLFQGLVDKDAFHTEIRMSHCDSVTVPPKDFFITASSQHCPVAAIEYPE
KKLFGLQFHPEVSDSQGIGDTILSNFVKHICRASETWKIETIEKQLIQRIKEQVGEKERVLLGLSGGVDSSVLAVLLHNA
LGDRLSCVFVDTGLLRKNEVEEVKQQFLSLGLEIIVEDASETFFYELSGIQDPEQKRKIIGSTFIEVFDKVSKNLEVQWL
AQGTIYSDVIESAKSCDATQVIKSHHNVGGLPEKLNLKLLEPLRFLFKDEVRALGKVLGLPEVFISRHPFPGPGLGVRVL
GEIRKEYVEIVKHADSIFIEELKKANLYDKVSQAFAVFLPVKSVAVKGDCRHYGYTIALRAVESSDFMTACWSPLSREFL
NRCSSRIINEIPEVSRVVYDISDKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 8e-104 48
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 8e-104 48
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 7e-104 48
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-97 44