Gene Information

Name : guaA (NSE_0887)
Accession : YP_506753.1
Strain : Neorickettsia sennetsu Miyayama
Genome accession: NC_007798
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 790828 - 792387 bp
Length : 1560 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGATGCCCGAAATAGCCATCATTGATCTAGGATCGCAGTTTACCCAGCTGATAGCTCGAAAGTTAAGGGAAAATGGATG
CTGCTCGTGTATCTATAACCCCTCTGGCTTTACTTTCTCCAATGACATAAAGGGTGTTATATTATCCGGTAGCCACCAGT
CTACCAGTGAGTATGCGAACTACAGAGACCTAATCGCAATGGTTCTGAGCCTGAATTCTACGCATGGTATACCAGTGTTA
GGAATCTGCTACGGAAAGCAACTCCTAAGCGATTTCTTAGGTGCTAGTGTGGTCTCTGGTAAAAACCGCGAATATGGAAG
GGCTAGACTCCAGATCGTTGCAGAAAGCCCGATTGTGAGCAACATCAGTGCCTCGGATTTTACGGTCTGGATGAGTCACG
GTGATGCGGTTGTGACGCTTCCTTGTGGTTTTAAATGTGTCGCAAAGACAGACGATTGCCAATTTGCACTAATTGCTGAT
GAAAACAGGAAGATATATGGCTTTCAGTTTCATCCTGAGGTCTCACACACTGAGAATGGTGGTGTCTTACTACGCAATTT
CATATCAATTGCAGGAGTTGAAAATACCTGGGATCTACAAGTTTTTTCCGAAGAAGAAAAACGCATGGTAGTTGCTACCA
CTGGTGATGCAGGTGTTCTTGCTGCAGTCAGCGGAGGTGTTGATTCAACAGTTGCAGCGAAATTTATGCACGGAGCAATA
GGTGAAAGGCTTCATTGCATTTTTGTAGATACAGGACTTCTAAGAAAAAATGAAGCTAATGAAGTGAAGGAATCATTTTC
ATCGTTGGGAATACCGCTGAAGATTGTTTTTGCAGCTGATAGGTTCTTTAAAAAGCTTGCTGGAGTTGCAGATCCCGAAC
AGAAGAGAAGAATTGTTGGAGAGACTTTTATTCAAGTATTTGAAGAAGAGGCTCTAAAAATCCAGGGTGTGGAATTTCTT
TTACAGGGCACTTTGTACCCCGACGTTATCGAATCGGGTGGTGGAGGTTCCCATACAATTAAATCTCACCACAATGTGGG
TGGGCTGCCCAAGAAAATGGGGTTAAAGTTGCTTGAGCCTTTTAGATTGCTCTTTAAAGATGAGGTGAGAGCAATTGGGC
GTCAGTTAGGTGTGAGTGAGGTCCTTTTAATGCGGCATCCGTCACCAGGACCTGCTCTGGCGATACGAATCCTAGGAGAA
GTAACTCAAGAAAAAGTGGCTGTGCTTCAGGATATCGATGAGATATACATCTCGACAATGAAGGAATACAATCTGTATTC
TCACATATGGCAGGCTTTCAGCGTATTATTACCAGTTTGTTCCGTTGGTGTGATGGGTGATAAGCGCTCTTATAACTATG
TTTGTGCGCTACGCGCTATTGTTTCTCACGATGGAATGACAGCTAGTGCCTATCCATTTGAGGCTCATGATGATGATAAA
TTGCGCTTTCTTTCCTTTCTGAATGAGGTTGCAACCAAAATACCCAATCGTGTGAGCGCAGTCTCTCGTGTAGTATATGA
CATTACATCCAAACCGCCAGCCACAGTTGAGTGGGAATAA

Protein sequence :
MMPEIAIIDLGSQFTQLIARKLRENGCCSCIYNPSGFTFSNDIKGVILSGSHQSTSEYANYRDLIAMVLSLNSTHGIPVL
GICYGKQLLSDFLGASVVSGKNREYGRARLQIVAESPIVSNISASDFTVWMSHGDAVVTLPCGFKCVAKTDDCQFALIAD
ENRKIYGFQFHPEVSHTENGGVLLRNFISIAGVENTWDLQVFSEEEKRMVVATTGDAGVLAAVSGGVDSTVAAKFMHGAI
GERLHCIFVDTGLLRKNEANEVKESFSSLGIPLKIVFAADRFFKKLAGVADPEQKRRIVGETFIQVFEEEALKIQGVEFL
LQGTLYPDVIESGGGGSHTIKSHHNVGGLPKKMGLKLLEPFRLLFKDEVRAIGRQLGVSEVLLMRHPSPGPALAIRILGE
VTQEKVAVLQDIDEIYISTMKEYNLYSHIWQAFSVLLPVCSVGVMGDKRSYNYVCALRAIVSHDGMTASAYPFEAHDDDK
LRFLSFLNEVATKIPNRVSAVSRVVYDITSKPPATVEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-99 46
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-99 46
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-99 46
guaA NP_938969.1 GMP synthase Not tested Not named Protein 7e-86 44