Gene Information

Name : SAOUHSC_02169 (SAOUHSC_02169)
Accession : YP_500656.1
Strain : Staphylococcus aureus NCTC 8325
Genome accession: NC_007795
Putative virulence/resistance : Virulence
Product : chemotaxis-inhibiting protein CHIPS
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 2034146 - 2034595 bp
Length : 450 bp
Strand : +
Note : secreted protein that specifically inhibits the activation of neutrophils and monocytes by binding to the formylated peptide receptor and the C5a receptor; blocks neutrophil migration towards the infection site and hinders the establishment of the initial

DNA sequence : 
ATGAAAAAGAAATTAGCAACAACAGTTTTAGCATTAAGTTTTTTAACGGCAGGAATCAGTACACACCATCATTCAGCGAA
AGCTTTTACTTTTGAACCGTTTCCTACAAATGAAGAAATAGAATCAAATAAGAAATTGTTAGAGAAAGAAAAAGCTTATA
AAGAATCATTTAAAAATAGTGGTCTTCCTACAACACTAGGAAAATTAGATGAACGTTTGAGAAATTATTTAAAGAAAGGC
ACAAAAAATTCTGCTCAATTTGAAAAAATGGTTATTTTAACTGAAAATAAAGGTTACTATACAGTATATCTGAATACACC
ACTTGCTGAAGATAGAAAAAATGTTGAGTTACTAGGTAAAATGTATAAAACATACTTCTTTAAAAAAGGAGAGTCTAAAT
CATCTTATGTAATTAATGGTCCTGGAAAAACTAATGAATATGCATACTAA

Protein sequence : 
MKKKLATTVLALSFLTAGISTHHHSAKAFTFEPFPTNEEIESNKKLLEKEKAYKESFKNSGLPTTLGKLDERLRNYLKKG
TKNSAQFEKMVILTENKGYYTVYLNTPLAEDRKNVELLGKMYKTYFFKKGESKSSYVINGPGKTNEYAY

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAKOR_01920 YP_008492108.1 Chemotaxis-inhibiting protein Chips Not tested ¥ÕSa3 Protein 6e-59 99
chs YP_494571.1 chemotaxis-inhibiting protein CHIPS Not tested ¥ÕSa3 Protein 6e-59 99
chs YP_494571.1 chemotaxis-inhibiting protein CHIPS Not tested ¥ÕSa3 Protein 6e-59 99
SA1755 NP_375050.1 chemotaxis-inhibiting protein CHIPS Not tested ¥ÕSa3 Protein 2e-58 98

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SAOUHSC_02169 YP_500656.1 chemotaxis-inhibiting protein CHIPS VFG2422 Protein 2e-59 99