Gene Information

Name : guaA (Francci3_0645)
Accession : YP_479758.1
Strain : Frankia sp. CcI3
Genome accession: NC_007777
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 734128 - 735798 bp
Length : 1671 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
TTGCAGCGTAGCAGTGCTGGCCGTGGTGCGGAGCCGACGGATACCGGCGCGGTTCGGGATGTTCCGCGGTCCCCGGCGGA
CGGCCCCAGCGGCCCGTCCGCGGTGGGGCCTGCGGGCTATGACACCGTGCTGGTGATCGATTTCGGTGCTCAGTATGCCC
AACTGATCGCCCGGCGCATACGCGAATGTCATGTGTATTCGGAGATCGTCCCGTGGGATATGTCGGTGGACGAGATCCTC
GCCCGGCGTCCGTCCGCACTGATCCTTTCTGGCGGCCCGAAGTCCGTCTACTCGCCTGGCGCGCCCCGGGTCGATCCTGC
GTTGTTCGCTACCGGAGTGCCTATTCTCGGTATCTGCTATGGCCATCAGGTCATGGCTCAGGCGCTTGACGGCGCCGTCG
CGCGCACGGGAACCGCCGAGTACGGAGCAACTCGTCTGTCGGTGTCGGATCCCGGGGTTCTCTTCGACGGTCTGCCCGTT
GTCCAGCAGGTCTGGATGTCGCACGGCGACTCGGTGACCGCCGCGCCGCCCGGCTTCCGGGTAACGGCTTCCACGCCGTC
GGCCCCGGTCGCCGCCTTCGAGGACCCCGCGCGTCGTCTCTATGGCGTGCAGTTCCACCCGGAGGTGGTCCACAGCGAGC
GAGGCATGGACGTGCTGCGGCACTTCCTGCTCGTGGGTGCGGGCTGCCGGCCCACCTGGACGATGATCAACATTGTCGAC
GAGGCTGTCGCGGCCGTCCGGGCCCAGGTCGGGACCGGACGGTTGATCTGCGGTCTGTCCGGCGGGGTGGACTCCGCGGT
CGCTGCCGCGCTCGTGCACCGGGCGGTGGGAGACGCGCTCACCTGCGTCTTCGTCGATCATGGTTTGCTGCGGGCCGGCG
AGGCGGAACAGGTCGAACGCGATTTCGTCGCGACTACCGGCGTGGATCTGGTCCATGTCAAGGCGGCCGACCGGTTCTCC
GCCGCGCTGTCCGGAGTGACCGACCCGGAGCGGAAGAGGAAGATCATCGGTCGTGAGTTCATCCGGGTTTTCGAGGAGTC
CGCCCGCGAACTGGAGGTCCGGGCGGAGGCGGAGGGCGCGACGATCGACTTTCTCGTGCAGGGGACATTGTATCCCGACG
TGATCGAATCCGGCTCGCCGACGGCCGCGAAGATCAAGTCGCATCACAACGTCGGTGGACTGCCCGAGGACCTGCGGTTC
GATCTGGTCGAGCCGCTTCGGACCCTGTTCAAGGACGAGGTCCGTCGGCTCGGCGAGGAGCTGGGGCTGCCCGAGGAGAT
CGTCTGGCGCCAGCCGTTCCCGGGCCCGGGCCTCGCCGTCCGCATCATCGGCGAGGTCACGCCCGAGCGGCTCGACGTGG
TGCGGGCGGCCGACGCGGTGATCCGGGAGGAGATTCGCAAGGCCGGCCTGGACCGCGAGATCTGGCAGGTCTTCGCGGTG
CTGCTCGCCGACGTGCGGTCGGTGGGCGTCCAGGGTGACGAGCGTACGTACGGCTTCCCGATCGTCCTGCGCGCGGTCAC
CAGCGAGGACGCGATGACCGCCGACTGGGCCCGGCTGCCCTACGGCCTGCTGGAACGCATCTCGAACCGGGTGGTCAACG
AGGTGCCGCAGGTTAACCGGGTGGTGTACGACATCACCTCCAAGCCTCCCGGCACGATCGAGTGGGAGTGA

Protein sequence :
MQRSSAGRGAEPTDTGAVRDVPRSPADGPSGPSAVGPAGYDTVLVIDFGAQYAQLIARRIRECHVYSEIVPWDMSVDEIL
ARRPSALILSGGPKSVYSPGAPRVDPALFATGVPILGICYGHQVMAQALDGAVARTGTAEYGATRLSVSDPGVLFDGLPV
VQQVWMSHGDSVTAAPPGFRVTASTPSAPVAAFEDPARRLYGVQFHPEVVHSERGMDVLRHFLLVGAGCRPTWTMINIVD
EAVAAVRAQVGTGRLICGLSGGVDSAVAAALVHRAVGDALTCVFVDHGLLRAGEAEQVERDFVATTGVDLVHVKAADRFS
AALSGVTDPERKRKIIGREFIRVFEESARELEVRAEAEGATIDFLVQGTLYPDVIESGSPTAAKIKSHHNVGGLPEDLRF
DLVEPLRTLFKDEVRRLGEELGLPEEIVWRQPFPGPGLAVRIIGEVTPERLDVVRAADAVIREEIRKAGLDREIWQVFAV
LLADVRSVGVQGDERTYGFPIVLRAVTSEDAMTADWARLPYGLLERISNRVVNEVPQVNRVVYDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 8e-147 65
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-132 55
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-132 55
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-132 55