Gene Information

Name : ureC (RHE_CH03305)
Accession : YP_470796.1
Strain : Rhizobium etli CFN 42
Genome accession: NC_007761
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 3469418 - 3471130 bp
Length : 1713 bp
Strand : -
Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp

DNA sequence :
ATGCCCTATAAGATCTCGCGCGCCGCCTATGCCGGCATGTTCGGACCGACCACCGGCGACAAGGTGCGCCTTGCCGATAC
GGAGCTCTTCATCGAGATCGAGAAGGATTTCACCACCTATGGCGAGGAGGTGAAGTTCGGCGGCGGCAAAGTGATCCGCG
ATGGCATGGGCCAGAGCCAGGTGACACGGGCCGACGGCGCGGTCGATACCGTCATCACCAATGCGGTGATCGTCGATCAT
TCCGGAATCTACAAGGCCGATATCGGGCTGAAGAACGGGCGCATCGCAGCGATCGGCAAGGCAGGCAATCCCGATATGCA
GCCCGGCGTCAACATCATCGTCGGCCCGGGCACGGAGGCGATCGCCGGCGAAGGGAAGATCGTCACCGCCGGCGGCATGG
ACAGCCATATCCATTTCATCGCGCCGCAGCAGATCGAGGAAGCGCTGATGTCGGGCATGACGTGCATGCTCGGCGGCGGC
ACGGGACCGGCGCACGGCACGCTTGCCACCACCTGCACGCCCGGCCCCTGGCATATCGCCCGCATGATCGAGGCGGCCGA
CGCCTTCCCGATGAACCTCGCTTTTGCCGGCAAGGGCAATGCCTCGCTGCCGGGGGCTTTGACCGAGATGGTGCTTGCCG
GCGCCACCTCGCTCAAACTGCATGAGGACTGGGGCACGACGCCCGGCGCCATCGACTGCTGCCTGTCGGTCGCCGACGAC
TATGACGTGCAGGTGATGATCCACACCGATACGCTGAACGAAAGCGGCTTCGTCGAAGATACAATCGGTGCGATCAAGGG
CCGCACCATCCATGCCTTCCACACCGAAGGGGCGGGCGGCGGGCACGCACCCGACATTATCAAGATCTGCGGCCAGCCGA
ACGTCATCCCGTCGTCGACCAATCCAACGCGGCCCTATACGGTCAATACGATTGCCGAGCATCTCGACATGCTGATGGTC
TGCCATCATTTGTCGCCGTCGATCCCCGAGGATATCGCCTTTGCGGAAAGCCGCATCCGCAAGGAGACGATCGCGGCCGA
AGACATTCTGCACGACATCGGCGCTTTCTCGATCATCTCGTCCGACAGCCAGGCCATGGGCCGCGTCGGCGAGGTGGCGA
TCCGCACCTGGCAGACGGCCGACAAGATGAAGCGCCAGCGCGGCCGGCTGAAGGAAGAGAACGGCGACAACGACAATTTC
CGCGTCCGCCGCTATATCGCCAAATACACGATCAATCCGGCAATCGCCCATGGCCTCAGCCATGAGATCGGCTCGGTCGA
GACCGGCAAACGCGCCGACCTCGTGCTGTGGAACCCGGCCTTCTTCGGCGTGAAGCCCGACATGGTGCTGCTCGGCGGCT
CGATCGCGGCGGCCCCCATGGGCGATCCGAACGCCTCGATCCCGACGCCGCAGCCGGTGCACTACCGGCCGATGTTTGCC
TCCTACGGCAAGAGCCTCACCAATTCCTCCGTCACCTTCGTCAGCCAGGCCTCGCTCGATGCCGGCCTGAAAGGCAGGCT
CGGAGTCGCCAAGGAACTGGTGGCGGTGAAGAATACGCGCGGCGGCATCTCCAAGGCATCGATGATACATAACGACCTGA
CGCCGGAGATCGAAGTCGATCCGGAGACCTATGATGTCAGGGCGAATGGCGAACTGCTGACCTGCGAGCCGGCGACGGTG
CTGCCGATGGCGCAGCGCTATTTCCTGTTTTAG

Protein sequence :
MPYKISRAAYAGMFGPTTGDKVRLADTELFIEIEKDFTTYGEEVKFGGGKVIRDGMGQSQVTRADGAVDTVITNAVIVDH
SGIYKADIGLKNGRIAAIGKAGNPDMQPGVNIIVGPGTEAIAGEGKIVTAGGMDSHIHFIAPQQIEEALMSGMTCMLGGG
TGPAHGTLATTCTPGPWHIARMIEAADAFPMNLAFAGKGNASLPGALTEMVLAGATSLKLHEDWGTTPGAIDCCLSVADD
YDVQVMIHTDTLNESGFVEDTIGAIKGRTIHAFHTEGAGGGHAPDIIKICGQPNVIPSSTNPTRPYTVNTIAEHLDMLMV
CHHLSPSIPEDIAFAESRIRKETIAAEDILHDIGAFSIISSDSQAMGRVGEVAIRTWQTADKMKRQRGRLKEENGDNDNF
RVRRYIAKYTINPAIAHGLSHEIGSVETGKRADLVLWNPAFFGVKPDMVLLGGSIAAAPMGDPNASIPTPQPVHYRPMFA
SYGKSLTNSSVTFVSQASLDAGLKGRLGVAKELVAVKNTRGGISKASMIHNDLTPEIEVDPETYDVRANGELLTCEPATV
LPMAQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 0.0 69
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 0.0 69
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 7e-166 62
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-167 62
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 2e-167 62
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-167 62

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC YP_470796.1 urease subunit alpha VFG0270 Protein 1e-169 64