Gene Information

Name : guaA (ELI_11710)
Accession : YP_459231.1
Strain : Erythrobacter litoralis HTCC2594
Genome accession: NC_007722
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2356604 - 2358178 bp
Length : 1575 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGACCAAGCGCATCTCCCCGATTCCATCCTCATCGTCGATTTCGGCAGCCAGGTGACCCAGCTGATCGCGCGCCGCGT
GCGCGAAGCCGGGGTCTATTCCGAAATCGCGCCCTTCAGCATGGCGGAAGAGGCCTTCCAACGGATGAAGCCCAAGGGCA
TCATCTTATCCGGCTCGCCCGCCGGGGTGCCGGACGAAGGCTCCCCGCGCGCACCGCAAATACTGTTCGAAGCCGGCGTG
CCGATCCTCGGCATCTGTTATGGCCAGCAGGTGATGACGCACCAGCTCGGCGGCGAAGTGCGGCCCGGACACGAGACCGG
CGACGGCGGCGAATTCGGGCGCGCCTACCTGACCGTAACCAAGGACTGCGCGCTGTTCGACGGCATGTGGCAGGTCGGCG
AGCGGCACCAGGTCTGGATGAGCCATGGCGACAAGGTCACGCAATTCGCCGACGGCTTCGAGATCGTCGCCACCAGCGAT
GGCGCGCCTTTCGCGGTTATCGCGGACGAAGCCCGCAAATTCTACGGCACCCAGTTCCACCCCGAAGTCGTCCATACGCC
CGACGGAGCCAAGCTGCTGGCCAATTTCGTCCGCCATGTCTGCGGGCTGGCGGGCGACTGGACCATGGCCGAATTCCGCA
AGACCAAGATCGAGGAAATCCGCGCGCAGGTGGGTGACGGCAAGGTCATCTGCGGCCTTAGCGGCGGTGTCGACAGCGCG
GTTGCGGCGGTGCTCATTCACGAAGCGATCGGCGAGCAACTGACCTGCGTCTTCGTCGACCACGGGCTGATGCGGCAGGG
CGAGGCCGAGCAGGTCGTGAGCCTGTTCCGCGGGCACTACAATATCCCGCTCGTCCATGTGGATGCGGAGGATATGTTCC
TCGGCGGGCTCGCGGGCGTCACCGACCCGGAGAAAAAGCGCAAGTTTATCGGCGGGGCCTTCATCGACCTGTTCGAGGAA
GAGGCGCGCAAGATCGGCGGGGCGGATTTCCTCGCCCAGGGCACGCTCTATCCCGACGTGATCGAATCGGTATCGTTCAC
CGGCGGGCCCAGCGTCACGATCAAGAGCCACCACAATGTCGGCGGACTGCCCGAGCGGATGAACATGCAATTGGTCGAGC
CTTTGCGCGAATTGTTCAAGGACGAGGTCCGCGCGCTGGGCCGCGAGCTCGGCCTACCCGATGTCTTCGTCGGCCGCCAC
CCCTTCCCCGGCCCCGGCCTCGCCATCCGCATCCCCGGCGAAGTCACCAAGGAACGCTGCGATATCCTGCGCAAGGCCGA
TGCGATCTATCTCGAGGAGATTCGCGCGGCCGGTCTCTACGATGCGATCTGGCAGGCCTTCGCCGTATTGCTCCCCGTCC
GCACTGTCGGCGTAATGGGCGATGCGCGCACCTATGACTCGGTCTGCGGCCTGCGCGCCGTGACCAGCACCGACGGCATG
ACGGCGGATGTCTATCCCTTCGACGCGACCTTCCTGACGCAGGTGGCGACGCGGATCGTCAACGAGGTGCAGGGCATCAA
CCGGGTGGTCTATGACTACACGTCGAAGCCGCCGGGGACGATCGAGTGGGAATAG

Protein sequence :
MDQAHLPDSILIVDFGSQVTQLIARRVREAGVYSEIAPFSMAEEAFQRMKPKGIILSGSPAGVPDEGSPRAPQILFEAGV
PILGICYGQQVMTHQLGGEVRPGHETGDGGEFGRAYLTVTKDCALFDGMWQVGERHQVWMSHGDKVTQFADGFEIVATSD
GAPFAVIADEARKFYGTQFHPEVVHTPDGAKLLANFVRHVCGLAGDWTMAEFRKTKIEEIRAQVGDGKVICGLSGGVDSA
VAAVLIHEAIGEQLTCVFVDHGLMRQGEAEQVVSLFRGHYNIPLVHVDAEDMFLGGLAGVTDPEKKRKFIGGAFIDLFEE
EARKIGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMQLVEPLRELFKDEVRALGRELGLPDVFVGRH
PFPGPGLAIRIPGEVTKERCDILRKADAIYLEEIRAAGLYDAIWQAFAVLLPVRTVGVMGDARTYDSVCGLRAVTSTDGM
TADVYPFDATFLTQVATRIVNEVQGINRVVYDYTSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-133 54
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-133 53
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-133 53
guaA NP_938969.1 GMP synthase Not tested Not named Protein 7e-120 52