Gene Information

Name : guaA (SG1748)
Accession : YP_455428.1
Strain : Sodalis glossinidius morsitans
Genome accession: NC_007712
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2990586 - 2992163 bp
Length : 1578 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACAGAAAATATCCATAAACACCGCATTCTGATTCTGGACTTCGGCTCGCAATACACCCAACTGGTGGCTCGCCGGGT
GCGCGAATTGGGCGTCTATTGCGAACTTTGGGCATGGGATGTAACCGAAGCACAAATACGCGAATTCAACCCCAGCGGCA
TCATCCTTTCCGGCGGTCCGGAAAGCACCACCGAGCAGGACAGCCCGCGCGCGCCGGATTATGTGTTTCAGGCAGGCGTG
CCGGTGCTGGGCGTTTGCTACGGCATGCAAACCATGGCGATGCAGCTTGGCGGCAAAGTCCAGGGTTCGACGCAGCGCGA
GTTTGGTTATGCCCAGGTAGAAGTGTTGACTGACAGCTTACTGGTGCGCGACATCCAGGACGACATCGGCACCGGCGGAG
CGCCACTGCTGGATGTCTGGATGAGCCATGGCGACAAAGTTACCGCCATTCCGGCGGATTTTGTCACCGTTGCCAGCACC
GAAACCTGCCACTTCGCCATTATGGCCAATGAAGAAAAACGGTTCTACGGCGTGCAATTTCACCCCGAAGTCACCCATAC
TCGTCAGGGTCAGCGCATGCTGGAACGCTTCGTACTTGATATTTGCCGGTGCACGCCGCTGTGGACGCCGGCCAAAATCA
TCGAAGATGCCGTCGCCCGTATCCGCGAACAGGTTGGCAACGATCGGGTCATTCTCGGTTTATCCGGCGGCGTAGATTCG
TCGGTTACCGCCATGCTGTTGCACCGGGCCATCGGCGAACGGCTGACCTGCGTGTTCGTCGATAACGGTCTGCTGCGCCT
TAACGAAGCCAGTCAGGTGATGGAAATGTTTGGCGATCACTACGGCTTGAACATTATCGCTGTACCGGCGGAAGACAGGT
TTCTTTCCGCGCTGGCCGGCATTGACGATCCGGAAACAAAACGGAAAACCATCGGCCGGGTATTTGTCGAGGTGTTTGAC
GAACAGGCTCTGAGCCTCTCCGACGTGAAATGGCTGGCGCAGGGCACCATTTACCCGGACGTCATCGAATCTGCCGCGTC
CGCCACCGGCAAAGCCCATGTCATCAAGTCGCACCATAACGTTGGCGGCCTGCCGAAAGAGATGAAAATGGGCTTGGTGG
AGCCGTTGAAAGAGCTGTTCAAGGATGAAGTACGCAAGATAGGCCTGGAACTCGGCCTGCCTTACGATATGCTTTATCGC
CATCCGTTCCCCGGACCGGGTTTGGGCGTGCGGGTGCTGGGTGAGGTGAAGAAAGAGTATTGCGATTTGCTGCGCCGCGC
CGATGCTATCTTTATCGAAGAACTGTACAAGGCGGATCTGTACAACAAAGTCAGCCAGGCCTTTACCGTCTTTTTGCCCG
TGCGCTCCGTCGGTGTCATGGGCGACGGCCGCAAATACGACTGGGTGGTTTCGCTGCGAGCGGTTGAAACCATCGACTTT
ATGACCGCCCATTGGGCGCACTTGCCTTATGATTTCCTGGGCCGCGTTTCCAACCGTATTATCAATGAGATCGACGGTAT
TTCCCGGGTCGTGTATGACATTTCCGGCAAACCGCCGGCGACGATTGAGTGGGAATAA

Protein sequence :
MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIREFNPSGIILSGGPESTTEQDSPRAPDYVFQAGV
PVLGVCYGMQTMAMQLGGKVQGSTQREFGYAQVEVLTDSLLVRDIQDDIGTGGAPLLDVWMSHGDKVTAIPADFVTVAST
ETCHFAIMANEEKRFYGVQFHPEVTHTRQGQRMLERFVLDICRCTPLWTPAKIIEDAVARIREQVGNDRVILGLSGGVDS
SVTAMLLHRAIGERLTCVFVDNGLLRLNEASQVMEMFGDHYGLNIIAVPAEDRFLSALAGIDDPETKRKTIGRVFVEVFD
EQALSLSDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELYKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEIDGISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 8e-126 50
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 6e-126 50
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 5e-126 50
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-110 47