|
Name : ureC (HCH_04523) Accession : YP_435648.1 Strain : Hahella chejuensis KCTC 2396 Genome accession: NC_007645 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 4649812 - 4651515 bp Length : 1704 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGGCAAAGATTTCTAGAGCCGCCTACGCCGACATGTTCGGGCCAACCGTAGGCGACCGGGTGCGTCTGGGCGACACCGA ATTATGGATCGAAGTGGAAAAAGATTACGCCACCTACGGCCACGAAGTGAAATTCGGCGGCGGCAAGGTCATCCGCGATG GCATGGGGCAGTCGCAACGCCCTAATACAGAAGCGGTGGACACCGTCATCACCAATGCCTTGATCCTCGACCACTGGGGC GTCGTCAAGGCGGATATCGGGCTCAAGCAGGGTCGCATCGCCGCCATCGGCAAAGCCGGCAACCCGGACATACAGGACAA CATCGACATCATTATCGGTCCCGGCACGGAAGTTATCGCTGGCGAAGGTATGATCGCCACCGCCGGCGGCATCGACGCCC ACATACATTTCATCTGTCCGCAGCAAATCGAAGAAGCGTTGATGTCCGGCGTCACCACCATGCTGGGCGGCGGCGCCGGT CCCGCCACCGGCACCAACGCCACCACCTGCACGCCCGGCCCCTGGCATATGGGCAAGATGCTGCAGGCCGCCGACGCTTT TCCCATGAACCTGGGCTTTCTCGGCAAAGGCAACGCCAGCCTTCCGGCAGCGCTGGAAGAGCAAATGCTCGCCGGCGCCA TGGGCTTGAAGCTGCATGAGGACTGGGGCACCACTCCCGCCTCCATCGACAACTGCCTCAATATCGCCGAAAAATACGAC GTGCAGGTGGCCATCCACACCGACACGCTGAACGAATCCGGATTTGTGGAAGACACGCTGGCGGCGTTCAAAGGACGCAC CATCCACACCTATCACACCGAAGGCGCCGGCGGCGGTCACGCGCCGGACATCATCAAAGCCTGCGGCGAGTTGAATGTGC TGCCCTCCTCGACTAATCCGACCCGGCCTTACACCATCAACACGGTGGACGAGCATCTGGACATGCTCATGGTGTGTCAC CATCTGGACCCGGATATCCCAGAAGACGTCGCCTTCGCCGATTCCCGCATCCGCAAGGAAACCATTGCCGCGGAAGACAT CCTGCACGATCTTGGCGCATTCAGCATGATCTCCTCCGACTCCCAGGCCATGGGCCGGGTTGGCGAGGTGGTTTGCCGCA CCTGGCAGACCGCCCACAAAATGAAAGTGCAGCGCGGACCGCTGGCGCAGGATTCCGAGCGCGCCGACAACTTTCGCGCC AAACGCTACATCGCCAAGTACACCATCAATCCCGCTATTGCTCACGGCATCGCCCATGAAGTGGGATCGCTTGAGCCCGG CAAGCTGGCGGATATCATTTTATGGCGGCCGGCCTTCTTCGGCGCCAAGCCCTCTCTGATCATCAAAGGCGGCATGATCG CCGCCGCTCCCATGGGCGACGCCAACGCATCCATCCCGACGCCACAGCCGGTGCATTATCGCCCCATGTTCGGCGCGTTT GGTCGGGCCATGCAGCAGACCCGTCTCACCTTTGTCTGTCAGGCCGCCCTGGATAACGGAGTAAAAGAGCAGTTTGGTTT GCAGTCCCCGCTCAGCGCCTGTCGCAATACCCGCACCGTCACTAAAAAGAGCATGGTGCTGAACGACCTGACGCCGCAGA TGGAAGTGGATTCGCAGACTTATGAAGTGCGCGCCAACGGCGAGCTGCTGGTCTGCGAGCCCGCGAAAGTGCTGCCTCTG GCGCAGCGTTATTTTCTGTTTTAA Protein sequence : MAKISRAAYADMFGPTVGDRVRLGDTELWIEVEKDYATYGHEVKFGGGKVIRDGMGQSQRPNTEAVDTVITNALILDHWG VVKADIGLKQGRIAAIGKAGNPDIQDNIDIIIGPGTEVIAGEGMIATAGGIDAHIHFICPQQIEEALMSGVTTMLGGGAG PATGTNATTCTPGPWHMGKMLQAADAFPMNLGFLGKGNASLPAALEEQMLAGAMGLKLHEDWGTTPASIDNCLNIAEKYD VQVAIHTDTLNESGFVEDTLAAFKGRTIHTYHTEGAGGGHAPDIIKACGELNVLPSSTNPTRPYTINTVDEHLDMLMVCH HLDPDIPEDVAFADSRIRKETIAAEDILHDLGAFSMISSDSQAMGRVGEVVCRTWQTAHKMKVQRGPLAQDSERADNFRA KRYIAKYTINPAIAHGIAHEVGSLEPGKLADIILWRPAFFGAKPSLIIKGGMIAAAPMGDANASIPTPQPVHYRPMFGAF GRAMQQTRLTFVCQAALDNGVKEQFGLQSPLSACRNTRTVTKKSMVLNDLTPQMEVDSQTYEVRANGELLVCEPAKVLPL AQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 0.0 | 72 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 0.0 | 72 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 6e-152 | 62 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 7e-152 | 62 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 7e-152 | 62 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 7e-152 | 62 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_435648.1 | urease subunit alpha | VFG0270 | Protein | 7e-155 | 63 |
