Gene Information

Name : guaA (Rru_A0355)
Accession : YP_425447.1
Strain : Rhodospirillum rubrum ATCC 11170
Genome accession: NC_007643
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 428986 - 430563 bp
Length : 1578 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACCGACCGCACTTCCGTTTCCGCCACCGACCGCATCCTGATTATCGATTTCGGCTCGCAGGTCACCCAGTTGATCGC
CCGGCGGGTTCGCGAAAGCGGCGTCTATAGCGAGATCCAGCCCTTCAATACGGTGACGGCGGCGTCGATCGCGGCTTTCG
CGCCCAAGGGCGTGATCTTGTCGGGCGGACCGGCCTCGGTGACGGCGGCCGATACGCCGCGCGCGCCGATCGAGCTGTTC
ACCATGGGTCTGCCGGTTCTGGGGATCTGCTATGGCCAGCAGACCATGGTCGCCCAATTGGGCGGCCGGGTGGAGGCCCC
CGATCACCGCGAGTTCGGCCGCGCCTTCGTCGAGGTCACCGCCGGCTGCGCGCTGTTTGACGGCGTGTGGACGCCGGGCG
AGCGTGATCAGGTGTGGATGAGCCACGGCGACCGCGTTGACGCCATCCCCGAAGGGTTTTCGGTGGTGGCGGTCAGCGAG
GGCGCGCCCTATGCCGCCATCGCCGATGAGGCCCGCCATTTCTATGGCGTGCAGTTCCACCCCGAGGTGGTTCACACCCC
CAAGGGCGCGGCGCTGTTGCGCAATTTCACCCATGGCATCTGCGGCTGTGGCGGCGATTGGACGATGGCCGCCTTCAAGG
ATCAGGCGATCGCCCGGGTGCGCGAGCAGGTGGGGAGCGGCCGGGTGATCTGCGGGTTGTCGGGCGGCGTCGACAGCTCG
GTGGTGGCGGCGCTGATCCACGAGGCGATCGGCGAGCAGCTGGTCTGCGTGCTGGTCGATCACGGCATGATGCGCCAGGG
CGAGACCGAGCAGGTGGTGCGCGTTTTCCGCGACCGCTTCAACATCACCCTGGTTCATCGCGACGCCAGCGAGTTGTTCC
TGGGCAAGCTTGACGGCGTGGTCGACCCCGAGGCCAAGCGCAAGATCATCGGCGCCACCTTCATTGATGTCTTCGACGAG
GAGGCGCGCAAGGTGGGCGGCGCCGATTTCCTGGCCCAGGGCACGCTCTATCCCGATGTGATCGAAAGCGTGTCGTTCAC
CGGCGGCCCGAGCGTGACGATCAAAAGCCACCATAATGTCGGCGGCCTGCCCGAGCGCATGAAGATGGCGCTGGTCGAAC
CCCTGCGCGAGCTGTTCAAGGACGAGGTGCGCGATCTGGGGCGCGAATTGGGCCTGCCCGACGAGATGGTCGGCCGCCAC
CCCTTCCCCGGCCCCGGCCTGGCCATCCGCATTCCCGGCCAGCCGCTGACCCGCGAGAAGCTTGATATCCTGCGCCGGGC
CGACGCCATCTATCTGGAAGAGATCCGCAACGCCGGGCTTTACGACGTCATCTGGCAGGCCTTCGCCGTGCTGCTGCCGG
TGCGCACCGTTGGGGTGATGGGCGACGCCCGCTCCTATGACTTCGCCCTGGCCCTGCGCGCCGTCACCTCGACCGACGGC
ATGACCGCCGACTACTACCCCTTCGACCACACCTTCCTCGGCCGCGTCGCCAACCGCATCATCAACGAGGTCAAAGGCGT
CAACCGCGTGGTCTACGACATCACCAGCAAGCCGCCCGGGACGATCGAGTGGGAATGA

Protein sequence :
MTDRTSVSATDRILIIDFGSQVTQLIARRVRESGVYSEIQPFNTVTAASIAAFAPKGVILSGGPASVTAADTPRAPIELF
TMGLPVLGICYGQQTMVAQLGGRVEAPDHREFGRAFVEVTAGCALFDGVWTPGERDQVWMSHGDRVDAIPEGFSVVAVSE
GAPYAAIADEARHFYGVQFHPEVVHTPKGAALLRNFTHGICGCGGDWTMAAFKDQAIARVREQVGSGRVICGLSGGVDSS
VVAALIHEAIGEQLVCVLVDHGMMRQGETEQVVRVFRDRFNITLVHRDASELFLGKLDGVVDPEAKRKIIGATFIDVFDE
EARKVGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMKMALVEPLRELFKDEVRDLGRELGLPDEMVGRH
PFPGPGLAIRIPGQPLTREKLDILRRADAIYLEEIRNAGLYDVIWQAFAVLLPVRTVGVMGDARSYDFALALRAVTSTDG
MTADYYPFDHTFLGRVANRIINEVKGVNRVVYDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-136 54
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-136 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-136 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 7e-118 52