Gene Information

Name : guaA (SAB0341)
Accession : YP_415843.1
Strain : Staphylococcus aureus RF122
Genome accession: NC_007622
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 387205 - 388746 bp
Length : 1542 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGAAATGGCAAAAGAACAAGAGTTAATCCTTGTCTTAGACTTTGGTAGCCAATACAACCAATTAATTACACGCCGAAT
TCGTGAAATGGGCGTTTATAGTGAATTACACGATCATGAAATTTCAATTGGAGAAATTAAGAAAATGAATCCAAAAGGTA
TCATCTTATCGGGTGGTCCAAACTCAGTTTATGAAGAAGGTTCATTTACAATTGATCCTGAAATATATAATTTAGGAATT
CCAGTACTTGGTATTTGTTATGGCATGCAATTAACTACTAAATTATTAGGTGGTAAAGTTGAGCGTGCTAATGAACGTGA
ATACGGTAAAGCAATCATTAATACGAAGTCAGATGAGTTATTCGCTGGCTTACCAGCAGAACAAACAGTTTGGATGAGTC
ATTCTGATAAAGTTATTGAAATTCCAGAAGGCTTTGAAGTTATCGCTGATAGCCCAAGCACAGACTATGCAGCAATCGAA
GATAAGAAACGTCGCATTTATGGTGTTCAATTCCATCCAGAAGTACGTCATACAGAATATGGTAATGATTTATTAAATAA
TTTTGTCCGTCGTGTTTGTGATTGTAAAGGTCAATGGACAATGGAAAACTTTATCGAAATCGAAATTGAAAAGATTCGTC
AACGCGTAGGAGACCGTCGTGTATTATGTGCAATGAGTGGCGGCGTAGATTCATCTGTTGTAGCTGTACTATTGCATAAA
GCAATTGGTGATCAACTAACATGTATCTTTGTAGACCATGGCTTACTTCGTAAAGGTGAAGGCGACATGGTTATGGAGCA
ATTCGGTGAAGGTTTCAACATGAATATTATTCGTGTTAATGCGAAAGATCGCTTTATGAATAAATTAAAAGGTGTTTCAG
ATCCTGAACAAAAACGTAAAATCATTGGTAATGAATTTGTATACGTATTTGATGATGAAGCATCAAAACTTAAAGGTGTA
GACTTCCTTGCGCAAGGAACACTTTATACAGACGTTATCGAATCAGGTACTAAGACAGCACAAACAATCAAATCACATCA
CAATGTTGGTGGATTACCAGAAGACATGGAATTCGAATTAATCGAACCAATCAATACATTGTTTAAAGATGAAGTACGTA
AATTAGGTATTGAGTTAGGTATTCCAGAACATTTAGTGTGGAGACAACCATTCCCAGGACCTGGTCTTGGCATTCGTGTA
CTTGGAGAAATTACTGAAGATAAACTAGAAATCGTTAGAGAATCAGACGCGATTTTACGCCAAGTGATTAGAGAAGAAGG
TCTTGAAAGAGAAATTTGGCAATACTTCACAGTGTTACCAAACATTCAATCAGTAGGTGTTATGGGAGACTACCGTACGT
ATGATCACACAGTAGGTATCCGTGCGGTAACATCTATCGACGGCATGACAAGTGACTTTGCACGCATCGATTGGGAAGTC
TTACAAAAGATTTCAAGTCGTATCGTAAACGAAGTAGACCACGTTAACCGCGTAGTTTATGACATTACATCAAAACCACC
AAGCACAATTGAGTGGGAATAA

Protein sequence :
MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISIGEIKKMNPKGIILSGGPNSVYEEGSFTIDPEIYNLGI
PVLGICYGMQLTTKLLGGKVERANEREYGKAIINTKSDELFAGLPAEQTVWMSHSDKVIEIPEGFEVIADSPSTDYAAIE
DKKRRIYGVQFHPEVRHTEYGNDLLNNFVRRVCDCKGQWTMENFIEIEIEKIRQRVGDRRVLCAMSGGVDSSVVAVLLHK
AIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVNAKDRFMNKLKGVSDPEQKRKIIGNEFVYVFDDEASKLKGV
DFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFELIEPINTLFKDEVRKLGIELGIPEHLVWRQPFPGPGLGIRV
LGEITEDKLEIVRESDAILRQVIREEGLEREIWQYFTVLPNIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEV
LQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 0.0 99
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 0.0 99
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 0.0 99
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-131 50