Gene Information

Name : thyA (Nmul_A1962)
Accession : YP_412649.2
Strain : Nitrosospira multiformis ATCC 25196
Genome accession: NC_007614
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 2256598 - 2257392 bp
Length : 795 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGCGCCAGTACCTCGATCTCATGCAGCATGTTCTGGAGCACGGACAAAAAAAATCCGATCGCACCGGCACAGGCACTCT
CTCCGTTTTCGGCTACCAGATGCGCTTCGACCTGTCTGAAGGTTTTCCCCTGCTGACGACAAAGAAACTGCATCTGAAAT
CCATCATTTACGAACTGCTCTGGTTTTTGAAAGGGGATACCAATATAAGGTATCTCAACGAAAATGACGTTTCCATCTGG
GATGAATGGGCGGATGAGAATGGCGATCTGGGACCGATATATGGCCGCCAGTGGCGCTCCTGGCCGAACGGGAAGGGAGG
CCATATCGATCAGATCGAACAGGTAGTCGAGCAGATCAGGAACACGCCCGATTCCCGGCGCATGCTGGTATCGTCCTGGA
ATGTGGGGGAACTGCAGGAAATGAAGCTGGCGCCGTGCCACGCGCTGTTTCAGTTCTATGTGGCGGAGGACAAGCTTTCC
TGCCAGCTTTACCAGCGCAGCGCTGACATCTTCCTGGGCGTTCCGTTCAATATTGCCTCCTATGCTCTGCTTACGCTCAT
GCTGGCGCAAAGCTGTGATTTACGCGCGGGTGAATTCGTCCATACTTTTGGCGATGCGCATCTTTATCTCAACCATCTGG
AACAGGCACGCGAGCAATTGGAGCGGGGGCCGAAAAAACTGCCTATCATGAAATTGAACCCGGCAATCCGGAACGTTTTC
GACTTCCGGTATGAGGATTTCAACCTGGAAGGGTACGACCCTCATCCGTCAATCAAGGCACCCATTGCAGTATGA

Protein sequence :
MRQYLDLMQHVLEHGQKKSDRTGTGTLSVFGYQMRFDLSEGFPLLTTKKLHLKSIIYELLWFLKGDTNIRYLNENDVSIW
DEWADENGDLGPIYGRQWRSWPNGKGGHIDQIEQVVEQIRNTPDSRRMLVSSWNVGELQEMKLAPCHALFQFYVAEDKLS
CQLYQRSADIFLGVPFNIASYALLTLMLAQSCDLRAGEFVHTFGDAHLYLNHLEQAREQLERGPKKLPIMKLNPAIRNVF
DFRYEDFNLEGYDPHPSIKAPIAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 1e-77 61