Gene Information

Name : guaA (Nmul_A1199)
Accession : YP_411894.1
Strain : Nitrosospira multiformis ATCC 25196
Genome accession: NC_007614
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1385210 - 1386778 bp
Length : 1569 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
TTGGTCATGCATCAAAAAATACTCATCCTTGACTTTGGTTCCCAATATACGCAGTTGATTGCCCGCCGCGTGCGGGAAAG
CAATGCCTACTGTGAAATTCATCCTTTTGACATAAGCTCGCAATTCATCGGGAATTTCGCTCCGGCAGGCATTATCCTTT
CCGGGGGGCCAGCCTCTGTGGCCGAGAATGAAACGCCCCGCGCTCCCCAGATCGTCTTTGAGCTGGGAGTGCCGGTAATG
GGCATCTGCTATGGCATGCAAACCATGGCGGCCCAGTTGGGTGGTTCAGTTGAAAACTCGAAGGTGCGGGAATTCGGTTA
CGCCGAATTGCAGGTAAAAAACCTTGCCGGCCTGCTTCAGGATATCCATGATCGTACTGATGCATCGCGCCAAAAGCTTC
TGGATGTGTGGATGAGCCACGGCGACAGCGTAAACACTCTTCCTCCCGGTTTCCAGGTCATGGCAAGCAATCCTGCCACC
CCCTTGGCTGCCATAGCGGATGGAGCGCGCAGGTTCTACGGAATGCAATTCCATCCGGAGGTCACTCATACCCCGCAAGG
CAAAGCCATTATAGACAGGTTTGTCCATGAAATTTGCGGACTCGCTTATGACTGGAACATGCCCGACTATCTGGAGGAAA
TGGTTGGCAGAATCCGTTCCGAAGTGGGACCGGACGAGGTTATTCTAGGGCTGTCCGGAGGTGTGGATTCCTCGGTTGCA
GCGGCACTCATTCATCGTGCTATTGGCAAGCAGCTTACCTGTGTTTTCGTGGACAACGGCCTGCTGCGCCTGAATGAGGC
CGAACAGGTAATGGACACCTTCAGCCGGAATCTCGGCGTAAAAGTCATTCATGTCGATGCCAGCGAAGAATTCTTAGGAC
ATTTGCAAGGCATTACGGATCCGGAAGCGAAGCGCCGCATTATCGGACGCGAATTCGTCGAGGTATTCCAGCGGGAAGCA
GCAAAAATCGCTAATGCGCGCTGGCTTGCGCAGGGCACGATTTATCCGGACGTCATCGAATCCGCCGGCGCCAAAACAAA
AAAGGCAAACACGATCAAATCCCACCACAATGTCGGCGGCCTGCCGGAAACATTGCATCTGAAGCTTCTGGAGCCATTGC
GGGAATTGTTCAAGGATGAAGTACGCGAGCTTGGACTGACCCTGGGGCTGCCGCACGATATGGTCTTTCGTCACCCTTTT
CCCGGACCGGGGCTTGGAGTGCGTATTCTCGGTGAAGTCAAGCGCGAGTATGCCGAGTTATTGCGGCGTGCCGATGCAAT
CTTCATCGAGGAATTACGCAATGCGGGCTGGTATGAAAAAACGTCTCAGGCATTCGCGGTCTTTCTACCGGTGAAATCGG
TGGGGGTGATGGGCGACGGCCGCACTTATGATTTTGTCGTAGCCCTGCGCGCCGTTCAGACAGAGGACTTCATGACGGCA
CGCTGGGCGGAACTGCCTTACGCCCTGCTCGCGAGAATATCCAGCCGCATCGTGAACGAAGTACGTGGAATAAATCGCGT
GGTCTATGATATCTCCGGCAAGCCGCCAGCCACTATAGAGTGGGAATGA

Protein sequence :
MVMHQKILILDFGSQYTQLIARRVRESNAYCEIHPFDISSQFIGNFAPAGIILSGGPASVAENETPRAPQIVFELGVPVM
GICYGMQTMAAQLGGSVENSKVREFGYAELQVKNLAGLLQDIHDRTDASRQKLLDVWMSHGDSVNTLPPGFQVMASNPAT
PLAAIADGARRFYGMQFHPEVTHTPQGKAIIDRFVHEICGLAYDWNMPDYLEEMVGRIRSEVGPDEVILGLSGGVDSSVA
AALIHRAIGKQLTCVFVDNGLLRLNEAEQVMDTFSRNLGVKVIHVDASEEFLGHLQGITDPEAKRRIIGREFVEVFQREA
AKIANARWLAQGTIYPDVIESAGAKTKKANTIKSHHNVGGLPETLHLKLLEPLRELFKDEVRELGLTLGLPHDMVFRHPF
PGPGLGVRILGEVKREYAELLRRADAIFIEELRNAGWYEKTSQAFAVFLPVKSVGVMGDGRTYDFVVALRAVQTEDFMTA
RWAELPYALLARISSRIVNEVRGINRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-113 51
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-115 50
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-115 50
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 3e-115 50