Gene Information

Name : mxiA (SDY_P185)
Accession : YP_406186.1
Strain :
Genome accession: NC_007607
Putative virulence/resistance : Virulence
Product : MxiA
Function : -
COG functional category : U : Intracellular trafficking, secretion and vesicular transport
COG ID : COG4789
EC number : -
Position : 148836 - 150902 bp
Length : 2067 bp
Strand : +
Note : innermembrane protein, component of the Mxi-Spa secretion machinery

DNA sequence :
ATGAAAGTGATCCAGTCTTTTCTTAAGCAAGTAAGTACTAAGCCTGAATTAATTATATTAGTGCTTATGGTTATGATCAT
TGCTATGTTGATCATACCATTACCCACATACCTTGTTGATTTTTTAATAGGGCTTAATATTGTACTTGCTATTCTCGTTT
TTATGGGATCATTTTATATTGAAAGAATATTGAGTTTTTCTACATTCCCTTCGGTTTTGTTGATAACGACATTATTTCGT
CTCGCTTTATCAATAAGTACTAGTCGGCTAATTTTAGTTGATGCGGATGCGGGTAAAATTATTACTACATTTGGCCAGTT
TGTCATTGGTGATAGTCTGGCTGTAGGTTTTGTTATTTTTTCAATAGTAACTGTTGTGCAGTTCATTGTTATAACAAAAG
GATCTGAAAGGGTTGCGGAGGTAGCTGCTCGCTTTTCTCTTGACGGTATGCCGGGGAAACAAATGAGCATTGATGCGGAT
TTAAAGGCTGGAATTATTGATGCCGCAGGAGCTAAAGAAAGACGCAGTATTCTGGAACGTGAGAGTCAATTGTATGGTTC
ATTTGATGGAGCAATGAAGTTCATTAAAGGTGATGCAATTGCTGGCATCATTATTATTTTTGTCAATTTAATAGGAGGTA
TTTCTGTTGGTATGAGTCAACATGGAATGTCCCTATCTGGTGCATTATCTACTTATACTATACTAACTATTGGTGACGGA
TTGGTCTCTCAGATTCCTGCTCTGTTAATTTCTATAAGTGCAGGATTTATCGTTACAAGAGTTAATGGTGATAGCGATAA
TATGGGACGTAACATAATGTCCCAGATATTTGGGAATCCTTTTGTTCTCATTGTTACATCAGCTCTTGCCTTGGCGATAG
GGATGTTGCCAGGTTTTCCGTTTTTTGTTTTTTTCCTGATAGCAGTTACTTTGACGGCTTTATTCTATTATAAAAAGGTC
GTAGAAAGAGAAAAAAGTCTGTCTGAGTCTGATCCTAGTGGCTATACTGGTACATTTGATATTGATAATAGCCATGACTC
ATCTTTGGCAATGATAGAAAATCTGGATGCTATTAGTTCAGAAACCGTTCCTTTAATTTTATTATTTGCCGAAAATAAGA
TAAATGCAAATGATATGGAGGGGCTTATTGAAAGGATAAGAAGTCAGTTCTTTATTGATTATGGTGTCAGGCTTCCAACT
ATTTTATATAGAACAAGCAATGAGCTTAAGGTTGACGATATTGTTTTGTTAATAAATGAGGTGCGTGCCGATAGTTTTAA
TATATACTTTGACAAAGTATGTATTACAGATGAGAATGGAGATATAGATGCTCTAGGTATTCCTGTTGTTCCAACTTCAT
ATAATGAACGTGTTATTTCTTGGGTAGACGTTTCATATACAGAAAATCTAACTAATATTGATGCTAAAATTAAAAGCGCT
CAAGATGAATTTTATTACCAGTTGTCACAAGCCTTATTAAACAACATAAATGAGATTTTTGGCATACAAGAAACAAAAAA
TATGTTAGATCAGTTTGAAAATCGGTATCCTGATCTTTTAAAGGAAGTCTTCCGACATGTGACTATACAGAGAATATCTG
AGGTATTACAAAGATTGCTTGGAGAAAATATTTCTGTTCGCAATTTAAAACTTATTATGGAGTCTTTGGCGCTTTGGGCT
CCCAGAGAAAAAGATGTCATAACATTAGTTGAACATGTCCGTGCATCACTTTCTAGGTATATTTGTAGTAAAATAGCCGT
TTCTGGTGAGATTAAAGTTGTGATGCTTTCCGGATATATTGAGGATGCAATAAGAAAAGGGATAAGGCAAACCTCTGGTG
GCTCTTTCTTGAATATGGACATAGAGGTTTCGGATGAGGTAATGGAAACTTTAGCACATGCTTTGAGAGAATTGAGAAAT
GCAAAAAAAGATTTCGTTCTTTTGGTATCAGTAGATATACGTAGGTTTGTTAAAAGACTTATAGATAACAGATTTAAGAG
TATACTCGTTATATCGTATGCTGAGATTGATGAAGCATATACCATTAATGTATTGAAGACTATTTAG

Protein sequence :
MKVIQSFLKQVSTKPELIILVLMVMIIAMLIIPLPTYLVDFLIGLNIVLAILVFMGSFYIERILSFSTFPSVLLITTLFR
LALSISTSRLILVDADAGKIITTFGQFVIGDSLAVGFVIFSIVTVVQFIVITKGSERVAEVAARFSLDGMPGKQMSIDAD
LKAGIIDAAGAKERRSILERESQLYGSFDGAMKFIKGDAIAGIIIIFVNLIGGISVGMSQHGMSLSGALSTYTILTIGDG
LVSQIPALLISISAGFIVTRVNGDSDNMGRNIMSQIFGNPFVLIVTSALALAIGMLPGFPFFVFFLIAVTLTALFYYKKV
VEREKSLSESDPSGYTGTFDIDNSHDSSLAMIENLDAISSETVPLILLFAENKINANDMEGLIERIRSQFFIDYGVRLPT
ILYRTSNELKVDDIVLLINEVRADSFNIYFDKVCITDENGDIDALGIPVVPTSYNERVISWVDVSYTENLTNIDAKIKSA
QDEFYYQLSQALLNNINEIFGIQETKNMLDQFENRYPDLLKEVFRHVTIQRISEVLQRLLGENISVRNLKLIMESLALWA
PREKDVITLVEHVRASLSRYICSKIAVSGEIKVVMLSGYIEDAIRKGIRQTSGGSFLNMDIEVSDEVMETLAHALRELRN
AKKDFVLLVSVDIRRFVKRLIDNRFKSILVISYAEIDEAYTINVLKTI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
invA NP_461817.1 needle complex export protein Virulence SPI-1 Protein 0.0 65
invA YP_217815.1 invasion protein Virulence SPI-1 Protein 0.0 65
invA NP_457290.1 possible secretory protein (associated with virulence) Virulence SPI-1 Protein 0.0 65
invA NP_806499.1 virulence-associated secretory protein Virulence SPI-1 Protein 0.0 65
ECs3731 NP_311758.1 EivA Not tested LIM Protein 0.0 62
invA AAS66860.1 InvA Not tested SSR-2 Protein 4e-172 58
ysaV AAS66840.1 YsaV Not tested SSR-1 Protein 3e-151 53
unnamed AAL06368.1 EscV Virulence LEE Protein 1e-101 41
escV YP_003232152.1 T3SS structure protein EscV Virulence LEE Protein 3e-100 41
escV CAC81861.1 EscV protein Virulence LEE II Protein 5e-100 41
escV YP_003223476.1 translocator EscV Virulence LEE Protein 2e-100 41
escV AAK26714.1 EscV Virulence LEE Protein 2e-100 41
escV AAL57541.1 EscV Virulence LEE Protein 2e-100 41
escV CAI43875.1 EscV protein Virulence LEE Protein 1e-100 41
escV YP_003236089.1 putative translocator EscV Virulence LEE Protein 5e-101 41
lssD AAO18050.1 LssD Virulence TTSS locus Protein 8e-116 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
mxiA YP_406186.1 MxiA VFG1006 Protein 0.0 99
mxiA YP_406186.1 MxiA VFG0557 Protein 0.0 65
mxiA YP_406186.1 MxiA VFG2461 Protein 8e-158 56
mxiA YP_406186.1 MxiA VFG1780 Protein 1e-153 52
mxiA YP_406186.1 MxiA VFG0384 Protein 1e-111 41
mxiA YP_406186.1 MxiA VFG0064 Protein 8e-110 41