Gene Information

Name : thyA (LSA1001)
Accession : YP_395612.1
Strain : Lactobacillus sakei 23K
Genome accession: NC_007576
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 992134 - 993084 bp
Length : 951 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGTCAGAACAAGTATACCTCGATTTAGCACGGACAATCTTAGAAGAGGGTCACTACAAGGGAGATCGGACTAATACCGG
TACCTATAGCCTCTTTGGCTACCAAATGCGTTTTAATTTACAAGAAGGATTCCCTTTATTGACGACGAAGAAGATGCCTT
TTGGCTTAATCAAGAGTGAACTCTTGTGGTTTTTAAAAGGGGATTCGAACATTCGTTATTTATTACAACATAATAACCAT
ATTTGGGATGAATGGGCATTTGAACGCTTCGTTAAAAGTACTGATTACACCGGTCCTGACATGACCGATTTCAGTCACCG
GGCTCAAGACGATGCTGATTTCAAAGTTGTTTATCAAGAACAAATGCGCCTATTTAACGACCGGATCTTAGCCGACGAAG
GATTTGCAAAACAATACGGCGAATTAGGTGATATTTATGGTAAGCAATGGCGTGCTTGGCAAACACGTTCAGGCGAAACC
ATTGATCAGATTAAAAACGTCATCGAAATGATTAAAACGAATCCCGATTCACGACGGTTGATTGTGTCTGCTTGGAATCC
AGAAGATGTGCCTAGTATGGCTTTACCGCCTTGTCACACCATGTTCCAATTTTACGTCAACGACGGTAAGCTTTCGTGTC
AACTTTATCAACGAAGTGGGGATGTCTTCCTCGGTGTACCGTTTAACATCGCCAGTTATGCGTTATTAACGCATTTGATT
GCTCATGAAACTGGGCTTGAGGTCGGTGAATTCATCCATACTCTGGGGGATGCACATATTTATAGTAACCACGTGACCCA
AGTGAAGACTCAATTGGCACGATCAATGCATGCTGCACCCAAATTATGGTTAAACCCAGATAAGAAGAGCATTTTTGATT
TTGATGTTGCTGATATTAAAGTGGAAAATTATGAATCAGAACCCGCAATTAAAGCACCTGTTGCGGTATAG

Protein sequence :
MSEQVYLDLARTILEEGHYKGDRTNTGTYSLFGYQMRFNLQEGFPLLTTKKMPFGLIKSELLWFLKGDSNIRYLLQHNNH
IWDEWAFERFVKSTDYTGPDMTDFSHRAQDDADFKVVYQEQMRLFNDRILADEGFAKQYGELGDIYGKQWRAWQTRSGET
IDQIKNVIEMIKTNPDSRRLIVSAWNPEDVPSMALPPCHTMFQFYVNDGKLSCQLYQRSGDVFLGVPFNIASYALLTHLI
AHETGLEVGEFIHTLGDAHIYSNHVTQVKTQLARSMHAAPKLWLNPDKKSIFDFDVADIKVENYESEPAIKAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 1e-103 65
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 7e-57 49