Gene Information

Name : megL (GBAA_4906)
Accession : YP_021551.1
Strain : Bacillus anthracis Ames Ancestor
Genome accession: NC_007530
Putative virulence/resistance : Resistance
Product : methionine gamma-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.11
Position : 4458119 - 4459294 bp
Length : 1176 bp
Strand : -
Note : catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine

DNA sequence : 
ATGAAAAAGAAGCATATGGAGACAGCGTTAATTCATCACGGTTATACATCAGAGGAACATAAAGGAAGTTTAACACCGCC
TTTATTTCAAACGTCTACATTTACATTTGAGACTGCGCAGCAAGGAGAGGCGAGTTTTGCGGGAGTGGATCCATCTTATA
TTTACTCAAGACTTGGAAATCCGACTGTGAAATTATTTGAAGAACGTATGGCGGTGTTAGAAGGAGGAGAAGAAGCGCTT
GCTTTCGGGTCCGGTATGGCAGCTATTTCCGCAACGTTAATTGGTTTTCTAAAAGCTGGAGATCATATTATTTGTTCAAA
TGGATTATACGGATGCACGTACGGCTTTTTGGAAGTGTTGGAAGAAAAATTTATGATTACGCATTCGTTTTGTGATATGG
AGACAGAGGCTGATATTGAAAATAAAATTCGCCCAAATACAAAGCTTATTTTCGTTGAAACACCGATTAATCCGACAATG
AAATTAATTGATTTAAAACAAGTGATTCGGGTTGCGAAGCGAAATGGTTTACTTGTCATTGTTGACAATACGTTTTGTTC
ACCTTATTTACAAAGACCGCTTGAACTTGGCTGTGACGCCGTTGTTCATAGTGCGACAAAATATATTGGTGGCCACGGTG
ATGTTGTGGCGGGTGTAACAATTTGTAAAACGAGAGCGTTAGCTGAAAAAATCCGCCCGATGCGAAAAGATATCGGCGGT
ATTATGGCACCGTTTGATGCATGGTTATTGTTACGCGGATTAAAGACACTAGCGGTAAGAATGGACCGCCATTGTGATAA
TGCAGAAAAAATTGTATCGTTCCTAAAAAATCATGATGCGGTAGAAGGTGTTTGGTATCCAGAAGGGGAGTTAGCATCTC
GCCAAATGAAACGGGGCGGCGTTATATCTTTTTCAATTAAAGGCGGGAAAGAAGAGACGCAAGCGTTTATTAATGACCTC
TACTTTATTACAATTGCAGTCAGTTTGGGAGATACAGAAACGTTAATTCAGCACCCGGCAACGATGACGCACGCTGCGAT
TCCAGCTGAGTTAAGACAAGAAATGGGTATTTATGATAATTTAATACGTTTATCTGTCGGTTTAGAATCGTGGGAGGATA
TCGTTTCTGATTTAGAGCAAGCATTAAAGAAAATATCTACTGTTAGTAATCAATAA

Protein sequence : 
MKKKHMETALIHHGYTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEAL
AFGSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTM
KLIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGG
IMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPEGELASRQMKRGGVISFSIKGGKEETQAFINDL
YFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALKKISTVSNQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 9e-66 43
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 5e-67 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
megL YP_021551.1 methionine gamma-lyase BAC0207 Protein 8e-88 48