Gene Information

Name : guaA (Tcr_1615)
Accession : YP_391881.1
Strain : Thiomicrospira crunogena XCL-2
Genome accession: NC_007520
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1768800 - 1770380 bp
Length : 1581 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGTCACAAAACAACATTCATGAACATCGCATTTTAATTCTAGACTTTGGGTCTCAATACACGCAGTTGATCGCTCGACG
CATTCGAGAAATCGGTGTGTATTGTGAAGTGGAGCCATGGGATATTGATGTTGAGGATATTGTGAAATTTGGCGCAAGAG
GCATTATTTTATCCGGTGGACCTGAAACCGTGACGGGTGATAATGCACCGGTCGCGCCTGTAGAAGTGTTTGAATTAGGT
GTGCCTGTCCTAGGGATTTGTTACGGCATGCAAACCATGGCTGAGCAGTTGGGTGGTAAAGTTATTAATGCGACTGAACA
TGAATATGGTTATGCACAAGTTCGGGCTCATGGTCATACTAAGTTGTTAAACGACATTGAAGATCATGTGACTCCGGAAG
GTTATGGCATGCTGGATGTTTGGATGTCTCATGGCGACCGTGTTGATAAAATGCCGGAAGGGTTTAAATTGATGGCTTCA
ACTGGCAATTGTCCGATTGCCGGTATGGCTAATGAAGAAAAAGACTTTTATGGCATTCAGTTTCATCCAGAAGTCACGCA
TACCACTCAAGGTCAACGCATGATTGAGCGTTTTGTAGTCGACCTGTGTGGATGTGAAAAGCTTTGGACGACTGAAAATA
TCATCGATGACAGTATTGCGCGTATTCGTCAGCAGGTGGGGTCTGATGAAGTCTTGTTAGGCCTGTCTGGTGGGGTTGAT
TCTTCAGTGGTGGCCGCTTTATTACATAAAGCGATTGGTGACCAGTTAACGTGTGTTTTTGTGGATCACGGCTTGTTACG
TCATCAGGAAGGGGACCAAGTGATGTCCATGTTTGCTGAAAATATGGGGATCAAGGTCATTCGTGTGGATGCGGAAGATT
ATTTTATGAACGCATTGGCCGGCGAAGCGGATCCTGAGAAGAAACGTAAGATTATTGGTCATGCATTTATTGAAATGTTC
GATCAGGAATCGGCTAAATTGACGGGTGTGAAATGGCTGGCTCAAGGAACAATTTACCCAGATGTTATTGAATCGGCGGG
TTCTAAAACCGGAAAAGCCAAAGTAATCAAATCGCATCATAACGTCGGTGGCTTACCTGAAGATATGAAGCTGGAATTGT
TGGAACCATTAAGAGAGCTGTTTAAAGATGAGGTTCGTAGGCTTGGTGTGGCTTTGGGCTTGCCTTCGGATATGGTTTAT
CGCCATCCTTTCCCAGGGCCAGGCCTAGGAGTTCGAATTTTAGGTGAAGTTAAGAAAGAATATGCTGATATTTTACGTTT
AGCGGATCATATTTTTATTGAAGAACTTAGAGCGGCCGACTTGTACGACAAAACCTCGCAAGCCTTTACCGTTTTCTTAC
CCGTGAAATCTGTTGGAGTGGTGGGTGATGCCCGTCGTTATGATTATGTGGTGTCACTGAGAGCGGTTGAAACGATTGAC
TTCATGACGGCACGTTGGGCACACCTTCCTTACGATTTCTTGGAAAAAGTTTCTAACCGTATCATTAACGAAATCCCTCG
TATTACACGAGTAACGTATGATATTTCCAGTAAACCGCCTGCCACGATTGAGTGGGAATGA

Protein sequence :
MSQNNIHEHRILILDFGSQYTQLIARRIREIGVYCEVEPWDIDVEDIVKFGARGIILSGGPETVTGDNAPVAPVEVFELG
VPVLGICYGMQTMAEQLGGKVINATEHEYGYAQVRAHGHTKLLNDIEDHVTPEGYGMLDVWMSHGDRVDKMPEGFKLMAS
TGNCPIAGMANEEKDFYGIQFHPEVTHTTQGQRMIERFVVDLCGCEKLWTTENIIDDSIARIRQQVGSDEVLLGLSGGVD
SSVVAALLHKAIGDQLTCVFVDHGLLRHQEGDQVMSMFAENMGIKVIRVDAEDYFMNALAGEADPEKKRKIIGHAFIEMF
DQESAKLTGVKWLAQGTIYPDVIESAGSKTGKAKVIKSHHNVGGLPEDMKLELLEPLRELFKDEVRRLGVALGLPSDMVY
RHPFPGPGLGVRILGEVKKEYADILRLADHIFIEELRAADLYDKTSQAFTVFLPVKSVGVVGDARRYDYVVSLRAVETID
FMTARWAHLPYDFLEKVSNRIINEIPRITRVTYDISSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 5e-130 53
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 4e-130 53
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-130 53
guaA NP_938969.1 GMP synthase Not tested Not named Protein 5e-117 49