Gene Information

Name : guaA (Pfl01_4587)
Accession : YP_350315.1
Strain : Pseudomonas fluorescens Pf0-1
Genome accession: NC_007492
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 5185841 - 5187418 bp
Length : 1578 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGCCCTCGACATTCACGCTCACCGCATCCTGATCCTCGACTTCGGTTCGCAATACACCCAACTGATCGCCCGCCGCGT
GCGCGAGATCGGTGTGTACTGCGAACTGCACCCGTTCGACATGGACGAAGATGCGATCCGCGAATTTGCGCCAAAAGGCG
TGATCCTCGCCGGCGGTCCCGAGTCCGTGCACGAAGCCAACAGCCCGCGCTGCCCGCAAGCGGTTTTCGACCTGGGCGTA
CCGGTCTTCGGTATCTGCTACGGCATGCAGACCATGGCCGAGCAACTGGGCGGCAAGGTTGAAGGCTCCGAACTGCGTGA
GTTCGGTTATGCCCGCGTTGACGTGGTCGGCAAGAGCCGTCTGCTCGACGGCATCGAAGACCACATCGACGCCGACGGCC
TGTTCGGCCTCGACGTGTGGATGAGCCACGGTGACAAGGTCACCAAGATGCCAAGCGATTTCCACATTCTGGCCAGCACC
CCGAGCTGCCCGATCGCCGGCATGTTCAACGACGAACGCGCTTACTACGGCGTACAGTTCCACCCGGAAGTGACCCACAC
CAAGCAGGGCGGTCGCATCCTGTCGCGTTTCGTTCTCGACATCTGCGGCTGTGAAGCCCTGTGGACCCCGTCGAAGATCG
CCGAAGACGCCATCGCCAACATTCGCGCGCAGGTCGGCACTGACAACGTGCTGCTGGGTCTGTCCGGCGGTGTGGATTCC
TCGGTGGTTGCGGCGCTGCTGCACAAGGCCATCGGTGATCAACTGACCTGCGTCTTCGTCGACAACGGCCTGCTGCGCCT
GCACGAAGGCGAGCAGGTTATGGCCATGTTCGCCGAAAACATGGGCGTCAAGGTGATCCGCGCCAACGCTGAAGACCAGT
TCCTCAACAACCTGGCCGGCGAAGCCGATCCGGAGAAGAAGCGCAAGATCATCGGCCGCACCTTCATCGACGTGTTCGAT
GCCGAATCCTGCAAGCTGGACAACATCAAGTACCTGGCTCAGGGCACCATCTACCCGGACGTGATCGAGTCGGCTGGCGC
GAAAAGCGGCAAGGCCCACGTGATCAAGTCGCACCACAACGTGGGCGGCCTGCCGGAAGAAATGAACCTGAAACTGGTCG
AGCCACTGCGCGAACTGTTCAAGGACGAAGTCCGTCGTCTGGGTCTGGAACTGGGCCTGCCGTACGACATGGTCTACCGT
CACCCGTTCCCGGGCCCGGGCCTGGGCGTACGGATCCTCGGTGAAGTGAAGAAGGAATACGCCGACCTGCTGCGTCGCGC
CGACCACATCTTCATCGAAGAACTGCGCAAGGCCGACTGGTACCACAAGGTCAGCCAGGCGTTTGTCGTGTTCCAGCCGG
TGAAATCGGTGGGCGTGGTCGGCGATGGCCGCCGTTACGCCTGGGTCGTGGCCCTGCGTGCCGTGGAAACCATCGACTTC
ATGACCGCACGTTGGGCACACCTGCCTTACGAACTGCTGGAAACCGTTTCCGGCCGAATCATCAATGAAATCGAAGGCAT
CTCCCGCGTGACTTACGACGTGTCGAGCAAGCCGCCGGCGACGATTGAGTGGGAGTGA

Protein sequence :
MALDIHAHRILILDFGSQYTQLIARRVREIGVYCELHPFDMDEDAIREFAPKGVILAGGPESVHEANSPRCPQAVFDLGV
PVFGICYGMQTMAEQLGGKVEGSELREFGYARVDVVGKSRLLDGIEDHIDADGLFGLDVWMSHGDKVTKMPSDFHILAST
PSCPIAGMFNDERAYYGVQFHPEVTHTKQGGRILSRFVLDICGCEALWTPSKIAEDAIANIRAQVGTDNVLLGLSGGVDS
SVVAALLHKAIGDQLTCVFVDNGLLRLHEGEQVMAMFAENMGVKVIRANAEDQFLNNLAGEADPEKKRKIIGRTFIDVFD
AESCKLDNIKYLAQGTIYPDVIESAGAKSGKAHVIKSHHNVGGLPEEMNLKLVEPLRELFKDEVRRLGLELGLPYDMVYR
HPFPGPGLGVRILGEVKKEYADLLRRADHIFIEELRKADWYHKVSQAFVVFQPVKSVGVVGDGRRYAWVVALRAVETIDF
MTARWAHLPYELLETVSGRIINEIEGISRVTYDVSSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 8e-127 50
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-126 50
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 9e-127 50
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-112 47