Gene Information

Name : metB (NP4746A)
Accession : YP_331099.1
Strain : Natronomonas pharaonis DSM 2160
Genome accession: NC_007426
Putative virulence/resistance : Resistance
Product : cystathionine synthase/lyase (cystathionine gamma-synthase, cystathionine gamma-lyase, cystathionine beta-lyase )
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 2322234 - 2323433 bp
Length : 1200 bp
Strand : -
Note : -

DNA sequence : 
ATGGAGCCGACTGACCCTTCCGACGAGACGGACGAGGAGCCGGCCGACGGTCGCATCGAGACGCAGGCGATCCATGCCGG
CCAGTCGCCTGACGCCGAGACCGGCGCGATTATGCCACCCATCTACGCCACCTCGACCTACGAGCAGGACGCCCCCGGTG
AGGACCGCGGCTACGAATACTCCCGGACGGGCAACCCCACGCGGACGGCCCTTGAGGACAACCTCGCCGCGCTCGAAGGC
GGCGACTACGGACGGGCCTTCGCCAGCGGCATGGCCTCTATCAATACGGTGCTGAATCTGCTGTCGGCCGGCGACCATGT
TGTTGCCGGCGACGATGTCTACGGCGGCACCCACCGCCTCTTTCGGGAGGTCTTCGAGCAGTACGACCTCTCGTTTTCCT
TTGTCGATACGACCGACCTCGACGCCGTCGAGGCGGCCATCCGCCCGGAAACGGAACTGCTCTGGGTCGAGACGCCGACC
AACCCGCTGTTGCGCATCAATGATATCGAGGCGCTGTCGGCCATCGCCCACGACCACGACGCGCTCTGTGCGGTCGACAA
CACCTTTGCCACGCCGTATCTGCAACGCCCGCTCGAACACGGCGCAGACATCGTCTCACACTCGCTGACGAAATACCTCG
GCGGCCACTCCGACGTTGTCGGCGGCGCGCTCGTAACCGACGACGCTGACCTCGACGAGCAGTTGGGCTTCTATCAAAAC
AGCGTCGGCGCGACGCCCGACCCCTTCGCTTGCTTTCTGGTACTCCGTGGCACCAAGACGCTTCCTGTCCGCATGGACCG
CCACTGTGCGAACGCCGAAACCATCGCCGAAAAGCTCGATGCCCACCCGGCCGTCGACCGCGTCCATTACCCGGGTCTCG
ATGACCACCCCGGCCACGAACTCGCGGCCGAACAGATGGACGGCTTCGGCGGGATGGTCAGCGTCGAACTCGATGCGACG
CTTGAGGAGACGCGTGAGGTTGTCTCCTCGACGGAGGTGTTCACCCTCGCTGAGAGCCTCGGCGGCGTCGAAAGCCTTCT
CGAACAGCCGGCGACGATGACCCACGCCTCGATTCCGCCCGAGGAGCGCCGCGCTGCGGGGCTTACTGACGGACTCATCC
GGCTGAGCGTCGGCACCGAACACGTCGATGACCTCTGGGCCGACCTCGAAGCGGCCATCGAAGACGCTGTCGAGTACTGA

Protein sequence : 
MEPTDPSDETDEEPADGRIETQAIHAGQSPDAETGAIMPPIYATSTYEQDAPGEDRGYEYSRTGNPTRTALEDNLAALEG
GDYGRAFASGMASINTVLNLLSAGDHVVAGDDVYGGTHRLFREVFEQYDLSFSFVDTTDLDAVEAAIRPETELLWVETPT
NPLLRINDIEALSAIAHDHDALCAVDNTFATPYLQRPLEHGADIVSHSLTKYLGGHSDVVGGALVTDDADLDEQLGFYQN
SVGATPDPFACFLVLRGTKTLPVRMDRHCANAETIAEKLDAHPAVDRVHYPGLDDHPGHELAAEQMDGFGGMVSVELDAT
LEETREVVSSTEVFTLAESLGGVESLLEQPATMTHASIPPEERRAAGLTDGLIRLSVGTEHVDDLWADLEAAIEDAVEY

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 6e-79 49
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 4e-80 49
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 4e-64 45

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metB YP_331099.1 cystathionine synthase/lyase (cystathionine gamma-synthase, cystathionine gamma-lyase, cystathionine beta-lyase ) BAC0207 Protein 1e-64 44