|
Name : ureC (NP2010A) Accession : YP_326658.1 Strain : Natronomonas pharaonis DSM 2160 Genome accession: NC_007426 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 979225 - 980937 bp Length : 1713 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGACGAAAACGCTGCCCCGCGAGGAGTACACCGACCTCTTCGGCGCGACAGTCGGCGACCGGATTCGGCTCGGCGACAC CTCGCTGCTGGCCGAAATCGAACACGACCACGCCACCTACGGCGATGAGGCGGTTTTCGGCGGCGGCAAAACGATGCGGG ACGGAATGGGCATGCAGTCGGGGACGACACAGGCCGACGGCGCTCTCGACTGGGTGTTCAGCAACGTCGTCGTCGTTGAC CCGGTTCTCGGCATCCGGAAAGGCGACATCGGCGTCCGAAACGGCCGCATCGTCGGCGTCGGCAAGGCCGGCAACCCGGA CACTATGGACGGGGTCGACGACGAACTGGTCGTCGGCCCGAGCACTGATACTGTCCCCGCGGACGGTCTCATCGCCACGC CCGGCGGCCTCGACATTCACGTCCACTTCAACAGCCCACAGCTCGTCGACCACGCCCTCGCCAGCGGCATTACGACGATG TTCGGCGGCGGCTACGGCGGCGGCGCAACGACCTGTACACCCGGCCCGAACAACGTCAAGCGGTTCCTGCAGGCAGCCGA CGAGTGGCCGGTTAACGTCGGTTTCTACGGCAAGGGCAACAGCAGCCAGCCGGAGGGCCTGGCAGAACAGGTCGAAGCCG GCGCTTGTGGAATGAAACTCCACGAGGACTGGGGGTCGACGCCGGCGGCTATCGACACCTGCCTCGAATACGCCGAGTCG GCCGACATTCAGGTCTGCATCCACACGGACACGCTCAACGAGTCCGGCTTCGTCGAGGAGACGTTCGACGCCATCGACGG CCGGGCCATCCACACCTTCCACATTGAGGGAGCCGGCGGCGGCCACGCCCCGGACGTGCTTGAACTGGTCGGCCACGAGC ATATGCTGCCGTCGTCGACGAACCCCTCGATGCCCTACACCGAGAACACCTTCGACGAACATCTGGATATGGTGATGGTC TGTCACCATCTCAACCCGGACGTTCCCGAGGATGTCGCCTTTGCCGAATCCCGCATCCGCGCCGAGACCATCGCTGCGGA GGACGTCCTGCACGATACGGGCGCTATCAGCATGATGACCTCCGATTCGCAGGCGATGGGCCGGATGGCGGAGGTCATTT CCCGGACATGGCAGACCGCGGATAAGATGAAACAGCAACGTGGGCCGCTGCCCGAAGACGACGGCACCGACGCTGACAAC CACCGCATCAAGCGCTACGTCGCCAAGTACACCATCAACCCCGCTATCGTCGCGGGCATCGACGACTACGTCGGCTCCAT AGAGCCGGGGAAACTGGCTGATATCGTCCTCTGGGAACCGGCCTTCTTCGGCATCAAGCCGAAAACCGTCATCAAGGGCG GCTTCCCGGTTTACAGCCAGATGGGCGAGGCCAACGGCTCGTTGATGACGTGTGAACCCGTCGAGATGCGCCCGCGAGCC GGCGCAATGGGGAACGCAAAGCACGGGCTCTCGGTGACGTTCGTCAGCGGCACAGCCCACGAGGCGGGCGTCGGCGACGC CTACGGCCTCGATACGCCGGTCAGACCCGTCGACGGGACCCGCTCGGTTCGGAAGGCCGACATGCTGTACAACGACTACT GTCCCGACGACATCGACATCGACGCACAGACGTTCGAGGTATCGATAGACGGCGAGCACGTGACGTGTGAGCCGGCAGAC GAACTCCCCCTCGCACAGCGGTACCACCTATGA Protein sequence : MTKTLPREEYTDLFGATVGDRIRLGDTSLLAEIEHDHATYGDEAVFGGGKTMRDGMGMQSGTTQADGALDWVFSNVVVVD PVLGIRKGDIGVRNGRIVGVGKAGNPDTMDGVDDELVVGPSTDTVPADGLIATPGGLDIHVHFNSPQLVDHALASGITTM FGGGYGGGATTCTPGPNNVKRFLQAADEWPVNVGFYGKGNSSQPEGLAEQVEAGACGMKLHEDWGSTPAAIDTCLEYAES ADIQVCIHTDTLNESGFVEETFDAIDGRAIHTFHIEGAGGGHAPDVLELVGHEHMLPSSTNPSMPYTENTFDEHLDMVMV CHHLNPDVPEDVAFAESRIRAETIAAEDVLHDTGAISMMTSDSQAMGRMAEVISRTWQTADKMKQQRGPLPEDDGTDADN HRIKRYVAKYTINPAIVAGIDDYVGSIEPGKLADIVLWEPAFFGIKPKTVIKGGFPVYSQMGEANGSLMTCEPVEMRPRA GAMGNAKHGLSVTFVSGTAHEAGVGDAYGLDTPVRPVDGTRSVRKADMLYNDYCPDDIDIDAQTFEVSIDGEHVTCEPAD ELPLAQRYHL |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 2e-132 | 57 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 2e-132 | 57 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 8e-134 | 54 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-133 | 54 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 1e-133 | 54 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-133 | 54 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_326658.1 | urease subunit alpha | VFG0270 | Protein | 1e-131 | 53 |
