Gene Information

Name : thyA (Nwi_2351)
Accession : YP_318957.1
Strain : Nitrobacter winogradskyi Nb-255
Genome accession: NC_007406
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 2572152 - 2572946 bp
Length : 795 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAATCAGTATCACGATCTGCTCGAACGAATTCTTGGTGAGGGTACGGAGAAGCATGACCGTACCGGCACCGGAACGCT
GTCCGTCTTCGGGCATCAGATGCGCTTCGATCTCGCCTCCGGCTTCCCGATGCTGACCACCAAGAAGCTCCCTTTCAGGT
CGATCGTGCATGAACTGCTCTGGTTCCTGAGGGGCGAGACCAACATCAAGTATCTGAAAGACAACGGGGTCTCGATCTGG
GACGAGTGGGCCGATGCAAATGGCGATCTAGGCCCGGTATATGGCTCGCAATGGCGTTCATGGCCCGCGCGGGACGGACG
CGGCATCGACCAGATCGCCAACGTCATTGACCTGATTCAGCGCAATCCCGACTCGCGGCGGCTGATCGTCAGCGCGTGGA
ATCCCGCCGACGTCGACAGGATGGCGCTGCCGCCGTGCCATTGCCTGTTTCAGTTCTATGTCGCCGGCGGGAAGCTGTCA
TGCCAGCTTTATCAGCGCTCGGCCGACGTGTTCCTCGGCGTGCCCTTCAATATCGCGTCCTATGCGCTGCTGACGATGAT
GGTCGCGCAGGTCACGGGGCTCAAGCCGGGCGACTTCGTCCACAGCCTGGGCGATGCGCACCTCTATTCAAATCATCTCG
ATCAGGCCCGGCTTCAACTGTCGCGGCCGACGCGGCCGCTGCCGACGATGACCATCAATCCCGAGGTGAAGGATATCTTC
GCGTTCCGCTACGAGGATTTCAGGCTCGAGAACTACGATCCCCATCCGCACATCAAGGCCGAGGTCGCGGTATGA

Protein sequence :
MNQYHDLLERILGEGTEKHDRTGTGTLSVFGHQMRFDLASGFPMLTTKKLPFRSIVHELLWFLRGETNIKYLKDNGVSIW
DEWADANGDLGPVYGSQWRSWPARDGRGIDQIANVIDLIQRNPDSRRLIVSAWNPADVDRMALPPCHCLFQFYVAGGKLS
CQLYQRSADVFLGVPFNIASYALLTMMVAQVTGLKPGDFVHSLGDAHLYSNHLDQARLQLSRPTRPLPTMTINPEVKDIF
AFRYEDFRLENYDPHPHIKAEVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 4e-81 62