Gene Information

Name : Tbd_1505 (Tbd_1505)
Accession : YP_315263.1
Strain : Thiobacillus denitrificans ATCC 25259
Genome accession: NC_007404
Putative virulence/resistance : Virulence
Product : 3-deoxy-manno-octulosonate cytidylyltransferase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1212
EC number : 2.7.7.38
Position : 1594649 - 1595407 bp
Length : 759 bp
Strand : -
Note : CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS

DNA sequence :
ATGCACTTTCGCGTCGTCATTCCCGCGCGCTACGGGTCGAGCCGCCTGCCGGGCAAGCCGCTCGCCGACATCGGCGGCAG
GCCGATGGTGCTGCACGTGCTCGACCGCGCCCTGCAGGCCGGCGCCGAGTCGGTCGTCGTCGCGACCGACGACGCCCGGG
TGCAGGCGGCGGTCGAAGCGGCTGGCCATCAGGCGCTGCTGACCTCGCCCGATCATCAGTCGGGCACCGAACGTCTGGTC
GAAGTCGCCGAAACGCTCGGCTGGCCGGATGACACGCTCGTGGTCAATGTGCAGGGCGACGAGCCGCTGATCGATCCGGC
GCTGATACGCGAGGCCGCGCGCCAGCTTGTCGTGCACACCGACGCCGTGATGGCGACCCTGGCACACCCGATCCACGACC
ACGCCGACTTCGTCAATCCGAACGTCGTCAAGGTCGTCGCCGACGAAGCCGGCTACGCGGTCTACTTCAGCCGCGCGCCG
ATCCCCTGGCCACGCGACGCCTTCGCGGCCGAGCAGCCGATGCCGCACGAAATCGGCGCGCTACGTCACATCGGTCTCTA
TGCCTATCGCGCGGGTTTTCTGCGCACCTACGCGAGCCTCGCGAGTTCGCCGCTCGAACGCTGCGAGATGCTCGAGCAAT
TGCGCGTGCTGTGGCACGGCTACCGCATCAGTCTCGGCGTCACGCCGACCGCGCCGGCCCCCGGCGTCGACACGGCGGAC
GACCTGGCGCGCGTCAGGGCGCTGTTCGCGGCTGTTTAA

Protein sequence :
MHFRVVIPARYGSSRLPGKPLADIGGRPMVLHVLDRALQAGAESVVVATDDARVQAAVEAAGHQALLTSPDHQSGTERLV
EVAETLGWPDDTLVVNVQGDEPLIDPALIREAARQLVVHTDAVMATLAHPIHDHADFVNPNVVKVVADEAGYAVYFSRAP
IPWPRDAFAAEQPMPHEIGALRHIGLYAYRAGFLRTYASLASSPLERCEMLEQLRVLWHGYRISLGVTPTAPAPGVDTAD
DLARVRALFAAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
kpsU YP_854332.1 3-deoxy-manno-octulosonate cytidylyltransferase Not tested PAI I APEC-O1 Protein 8e-39 46
kpsU AAZ04469.1 CMP-KDO synthetase Virulence PAI I APEC-O1 Protein 6e-39 46
kpsU CAE85213.1 KpsU protein Virulence PAI V 536 Protein 4e-39 46