Gene Information

Name : sigA (SSON_3223)
Accession : YP_312039.1
Strain : Shigella sonnei Ss046
Genome accession: NC_007384
Putative virulence/resistance : Virulence
Product : serine protease
Function : -
COG functional category : S : Function unknown
COG ID : COG4625
EC number : -
Position : 3389961 - 3393818 bp
Length : 3858 bp
Strand : -
Note : -

DNA sequence :
ATGAATAAAATTTATTCACTGAAATATAGTCATATTACAGGTGGATTAGTTGCTGTTTCTGAACTGACCCGGAAAGTTAG
TGTCGGTACATCAAGAAAGAAAGTTATCCTCGGTATTATTTTATCCTCAATATATGGAAGTTATGGCGAAACAGCATTTG
CAGCAATGCTGGATATAAATAATATATGGACCCGCGATTATCTTGACCTTGCTCAAAACAGAGGAGAGTTCAGACCGGGT
GCAACAAATGTTCAATTAATGATGAAAGATGGAAAGATATTTCATTTTCCAGAACTACCTGTACCTGATTTTTCTGCTGT
TTCCAACAAAGGTGCAACAACATCAATTGGAGGTGCGTACAGTGTTACTGCGACTCATAACGGTACACAGCATCATGCAA
TAACAACACAGTCATGGGATCAGACAGCATATAAAGCAAGTAACAGAGTATCATCTGGCGACTTTTCGGTTCATCGTCTG
AATAAATTCGTCGTGGAAACAACAGGGGTTACGGAGAGTGCCGACTTCTCACTTTCTCCCGAAGATGCGATGAAAAGATA
TGGCGTAAACTACAACGGTAAGGAACAAATAATTGGCTTCAGAGCAGGTGCCGGAACAACCTCAACGATATTAAACGGCA
AACAATATCTGTTTGGACAAAACTATAATCCCGACTTGTTAAGCGCAAGTCTTTTTAATCTGGACTGGAAAAACAAGAGT
TACATTTATACCAACAGAACCCCTTTTAAAAACTCACCAATTTTTGGCGATAGTGGTTCTGGTTCTTATCTATATGATAA
AGAACAACAAAAATGGGTTTTCCATGGTGTTACCAGTACAGTTGGTTTTCTCAGTAGTACCAATATAGCCTGGACAAACT
ACTCGTTATTTAATAATATTCTGGTAAACAATTTAAAAAAGAATTTCACAAACACTATGCAGCTGGATGGTAAAAAACAA
GAGTTATCATCGATTATAAAAGATAAGGACCTGTCTGTCTCAGGAGGAGGGGAATTAACGCTCAAGCAGGATACCGATCT
TGGCATTGGCGGGCTTATATTCGATAAGAACCAGACATATAAAGTGTACGGAAAAGATAAGTCTTATAAAGGTGCCGGGA
TAGATATTGATAATAATACCACCGTTGAATGGAATGTTAAGGGCGTTGCCGGAGATAATCTGCATAAAATAGGTAGTGGT
ACTCTGGATGTAAAAATAGCACAGGGAAATAACCTTAAAATAGGTAATGGGACTGTCATCCTTAGTGCTGAAAAAGCCTT
CAATAAAATTTACATGGCCGGAGGTAAAGGTACGGTAAAAATAAATGCCAAAGACGCTTTAAGCGAAAGCGGTAATGGCG
AAATCTATTTTACCAGAAATGGCGGAACACTGGATCTAAACGGCTATGACCAGTCATTTCAGAAAATCGCAGCAACAGAT
GCGGGAACAACCGTAACGAACTCAAACGTGAAGCAATCAACATTATCACTTACTAATACTGATGCATATATGTACCATGG
GAATGTATCAGGTAATATAAGCATAAATCATATTATCAATACTACCCAGCAACATAACAATAATGCCAATCTGATCTTTG
ATGGCTCAGTCGATATCAAAAACGATATCTCTGTCCGGAATGCACAGTTAACATTACAAGGACATGCGACAGAACATGCC
ATATTTAAAGAAGGCAATAACAACTGTCCAATTCCTTTTTTATGTCAAAAAGACTATTCTGCTGCCATAAAGGACCAGGA
AAGCACTGTAAATAAACGTTACAATACGGAATATAAGTCCAACAATCAGATAGCCTCTTTTTCCCAGCCCGACTGGGAAA
GTCGTAAATTTAATTTCCGGAAATTAAATTTAGAAAACGCAACCCTGAGTATAGGCCGGGATGCTAATGTAAAAGGACAC
ATAGAGGCTAAAAACTCTCAAATTGTTCTGGGAAATAAAACTGCATACATTGACATGTTCTCAGGAAGAAACATTACTGG
CGAAGGTTTTGGATTCAGACAACAGCTTCGCTCCGGGGATTCAGCAGGCGAAAGTAGTTTCAACGGCAGTCTGAGTGCTC
AAAACAGCAAAATAACTGTTGGTGATAAATCAACTGTTACTATGACTGGTGCATTATCCTTAATTAATACAGACCTGATT
ATCAACAAAGGAGCTACTGTTACCGCCCAGGGAAAAATGTATGTAGATAAAGCTATTGAACTGGCCGGAACCCTGACATT
AACAGGCACCCCTACAGAAAATAATAAATACAGCCCGGCAATCTATATGTCAGATGGATATAATATGACAGAAGATGGTG
CCACGTTAAAGGCTCAAAATTATGCCTGGGTCAATGGTAATATAAAATCAGACAAAAAAGCATCTATTCTGTTTGGTGTT
GACCAGTATAAAGAAGATAACCTGGACAAAACCACACACACACCGCTGGCTACAGGTTTGCTGGGTGGCTTTGATACTTC
TTATACCGGAGGTATTGATGCTCCTGCTGCCTCAGCCAGCATGTATAACACCTTATGGAGAGTAAACGGACAGTCAGCCC
TGCAATCATTAAAAACCCGCGACAGTCTTTTGTTGTTTAGTAACATAGAGAATTCGGGTTTCCATACTGTGACAGTAAAC
ACACTGGATGCCACTAATACTGCTGTGATTATGCGGGCTGATCTGAGCCAGTCTGTAAATCAATCGGATAAACTCATTGT
TAAAAATCAGTTAACCGGAAGCAATAACAGTCTGTCGGTCGATATACAGAAAGTGGGAAATAATAACTCAGGATTAAACG
TTGACCTGATAACAGCCCCAAAAGGAAGCAATAAAGAGATATTTAAAGCCAGTACTCAGGCCATAGGTTTCAGCAACATA
TCTCCTGTGATCAGCACGAAAGAGGATCAGGAACATACCACGTGGACCCTGACCGGATATAAGGTGGCTGAAAATACAGC
ATCTTCCGGTGCAGCAAAATCGTATATGTCCGGTAATTACAAAGCCTTCCTGACAGAAGTCAACAACCTGAATAAACGAA
TGGGGGATCTGCGTGACACCAATGGCGAGGCCGGTGCATGGGCCCGCATCATGAGCGGAGCAGGTTCAGCTTCTAGTGGA
TACAGTGACAACTACACCCATGTGCAGATTGGTGTGGATAAAAAACATGAGCTGGATGGACTTGACCTTTTCACTGGTCT
GACTATGACGTATACCGACAGTCATGCCAGCAGTAATGCATTCAGTGGCAAGACGAAGTCCGTCGGGGCAGGTCTGTATG
CTTCCGCTATATTTGACTCTGGTGCCTATATCGACCTGATTAGTAAGTATGTTCACCATGATAATGAGTACTCGGCGACC
TTTGCTGGACTCGGAACAAAAGACTACAGTTCTCATTCCTTGTATGTGGGTGCTGAAGCAGGCTACCGCTATCATGTAAC
AGAAGACTCCTGGATTGAGCCGCAGGCAGAACTGGTTTATGGGGCCGTATCAGGTAAACGGTTCGACTGGCAGGATCGCG
GAATGAGCGTGACCATGAAGGATAAGGACTTTAATCCGCTGATTGGGCGTACCGGTGTTGATGTGGGTAAATCCTTCTCC
GGTAAGGACTGGAAAGTCACAGCCCGCGCCGGCCTTGGCTACCAGTTTGACCTGTTTGCCAACGGTGAAACCGTACTGCG
TGATGCGTCCGGTGAGAAACGTATCAAAGGTGAAAAAGACGGTCGTATTCTCATGAATGTTGGTCTCAACGCCGAAATTC
GCGATAATCTTCGCTTCGGTCTTGAGTTTGAGAAATCGGCATTTGGTAAATACAACGTGGATAACGCGATCAACGCCAAC
TTCCGTTACTCTTTCTGA

Protein sequence :
MNKIYSLKYSHITGGLVAVSELTRKVSVGTSRKKVILGIILSSIYGSYGETAFAAMLDINNIWTRDYLDLAQNRGEFRPG
ATNVQLMMKDGKIFHFPELPVPDFSAVSNKGATTSIGGAYSVTATHNGTQHHAITTQSWDQTAYKASNRVSSGDFSVHRL
NKFVVETTGVTESADFSLSPEDAMKRYGVNYNGKEQIIGFRAGAGTTSTILNGKQYLFGQNYNPDLLSASLFNLDWKNKS
YIYTNRTPFKNSPIFGDSGSGSYLYDKEQQKWVFHGVTSTVGFLSSTNIAWTNYSLFNNILVNNLKKNFTNTMQLDGKKQ
ELSSIIKDKDLSVSGGGELTLKQDTDLGIGGLIFDKNQTYKVYGKDKSYKGAGIDIDNNTTVEWNVKGVAGDNLHKIGSG
TLDVKIAQGNNLKIGNGTVILSAEKAFNKIYMAGGKGTVKINAKDALSESGNGEIYFTRNGGTLDLNGYDQSFQKIAATD
AGTTVTNSNVKQSTLSLTNTDAYMYHGNVSGNISINHIINTTQQHNNNANLIFDGSVDIKNDISVRNAQLTLQGHATEHA
IFKEGNNNCPIPFLCQKDYSAAIKDQESTVNKRYNTEYKSNNQIASFSQPDWESRKFNFRKLNLENATLSIGRDANVKGH
IEAKNSQIVLGNKTAYIDMFSGRNITGEGFGFRQQLRSGDSAGESSFNGSLSAQNSKITVGDKSTVTMTGALSLINTDLI
INKGATVTAQGKMYVDKAIELAGTLTLTGTPTENNKYSPAIYMSDGYNMTEDGATLKAQNYAWVNGNIKSDKKASILFGV
DQYKEDNLDKTTHTPLATGLLGGFDTSYTGGIDAPAASASMYNTLWRVNGQSALQSLKTRDSLLLFSNIENSGFHTVTVN
TLDATNTAVIMRADLSQSVNQSDKLIVKNQLTGSNNSLSVDIQKVGNNNSGLNVDLITAPKGSNKEIFKASTQAIGFSNI
SPVISTKEDQEHTTWTLTGYKVAENTASSGAAKSYMSGNYKAFLTEVNNLNKRMGDLRDTNGEAGAWARIMSGAGSASSG
YSDNYTHVQIGVDKKHELDGLDLFTGLTMTYTDSHASSNAFSGKTKSVGAGLYASAIFDSGAYIDLISKYVHHDNEYSAT
FAGLGTKDYSSHSLYVGAEAGYRYHVTEDSWIEPQAELVYGAVSGKRFDWQDRGMSVTMKDKDFNPLIGRTGVDVGKSFS
GKDWKVTARAGLGYQFDLFANGETVLRDASGEKRIKGEKDGRILMNVGLNAEIRDNLRFGLEFEKSAFGKYNVDNAINAN
FRYSF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
sigA NP_708742.1 serine protease Virulence SHI-1 Protein 0.0 99
sigA AAF67320.1 exported serine protease SigA Virulence SHI-1 Protein 0.0 99
sigA NP_838462.1 serine protease Virulence SHI-1 Protein 0.0 99
sat YP_002414040.1 Serine protease Not tested Not named Protein 0.0 55
espC AAG37043.1 enterotoxin EspC Virulence espC PAI Protein 0.0 54
pic NP_838464.1 serine protease precurser Virulence SHI-1 Protein 2e-172 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
sigA YP_312039.1 serine protease VFG0630 Protein 0.0 99
sigA YP_312039.1 serine protease VFG0862 Protein 0.0 56
sigA YP_312039.1 serine protease VFG0844 Protein 0.0 56
sigA YP_312039.1 serine protease VFG0902 Protein 0.0 55
sigA YP_312039.1 serine protease VFG0772 Protein 0.0 54