Gene Information

Name : guaA (cbdb_A817)
Accession : YP_307879.1
Strain : Dehalococcoides sp. CBDB1
Genome accession: NC_007356
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 665053 - 666654 bp
Length : 1602 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
CTGGAAATCGCCAGAGAGAAGTCCGGTGCAAAATCGGAATGCATTGATTCAGGTGAAGAAACCCTGCGTGAATCAATTGT
TATTTTTGATTTTGGTTCCCAGTACAGCTTACTCATCGCCCGCCGCATACGTGAAATGCATGTCTATTGCGAGCTGGTTT
CCCACGATACTCCATGGGAGAAAATAGCCCATCTAAATCCCAGAGGTTTTATCCTCTCCGGAGGCCCTTCCAGCGTATAC
GAACCGGAAGCGCCTTTAGCTCCGGCCTATATATTTGAAAGCAAACTGCCGGTTTTGGGTATCTGCTATGGTATGCAGGC
CATTACCCAGCAATTGGGCGGTGTGGTTGAGCACAGTGATAAACGTGAGTATGGCCATGCCCTGCTCCACTCTAACGTGA
TAAATACTGAACTTTTGGCAGATATGCCTGAACCTTCTCCCGTCTGGATGAGCCATGGTGACCGTATTGAGAAACTGCCG
GCTGGCTTCAAGTCTCTGGCTTATACCGAAAACTGCCCGGTGGCAGTTATGGGTAATGAATCTGATATTTACGGTTTGCA
GTTTCACCCCGAAGTTGTCCATTCTCCCCACGGTAAAATCATTCTTAAAAATTTCGTTTTCAATATATGTAAATGCCACG
CTAACTGGACTATGGGCAACTATATTCAGGAAAGCATTCAAAACATACGTGAACAGGTCGGTGACGGGCAGGTTATCTGT
GCCCTTTCCGGCGGTGTAGATTCGGCTGTAGTGGCTTCCCTTATCCATAAAGCTATAGGTGACCAACTGACTTGTATTTA
TGTAAATAATGGTCTCCTTCGGCGTGAAGAAGCTGACCGTACTCTGCACGTTTTTAAGAACCACATGGGTATGAAAATAA
TATATGTAGACGCAATTGACCGCTTTCTTGAAAGCCTTGGCGGTATTACTGACCCCGAACAGAAACGCAAGGTTATCGGT
AGCGAATTTATAAAAGTATTTGAAGATGAAGCCTGTAAACTTGGGCAGATTGATTTCTTGGCACAAGGGACGTTGTACCC
GGATGTTATAGAAAGTGTATCTTCCGTATCAAAGGCTTCCGCCAAGATAAAAAGCCACCATAATGTGGGCGGTCTGCCCG
CCCATATGAAGCTAAAACTGATTGAGCCTTTGCGGTATCTCTTTAAAGATGAAGTCAGACTGCTGGGCAAGGAACTGGGT
CTGCCGGATGAAATGATTTGGCGCCAGCCCTTCCCCGGACCGGGTTTGGCTATCCGTATTATCGGGGAAGTTACCCGAGA
AAAGCTGGAAATCCTCCGCTCTGCGGACTGGATTGTTATGAGTGAAATAAAGAAAGCCAAAATGTATCACCAGGTATGGC
AAAGTTTTGCCATACTGACCGATGTTAAATCTGTGGGTGTTATGGGTGATTTCCGCACCTATGGTTATCTGGTAGCCATC
AGGGCTGTAACCAGTGAAGATGCCATGACTGCAGATTGGGCAAAACTGCCTTATGATTTGCTGTCCATTATATCCAACCG
GATTGTTAACGAGGTTAAAGAAGTGAACAGGGTGGTTTATGATATAAGCTCTAAACCGCCCTCCACTATTGAATGGGAGT
AA

Protein sequence :
MEIAREKSGAKSECIDSGEETLRESIVIFDFGSQYSLLIARRIREMHVYCELVSHDTPWEKIAHLNPRGFILSGGPSSVY
EPEAPLAPAYIFESKLPVLGICYGMQAITQQLGGVVEHSDKREYGHALLHSNVINTELLADMPEPSPVWMSHGDRIEKLP
AGFKSLAYTENCPVAVMGNESDIYGLQFHPEVVHSPHGKIILKNFVFNICKCHANWTMGNYIQESIQNIREQVGDGQVIC
ALSGGVDSAVVASLIHKAIGDQLTCIYVNNGLLRREEADRTLHVFKNHMGMKIIYVDAIDRFLESLGGITDPEQKRKVIG
SEFIKVFEDEACKLGQIDFLAQGTLYPDVIESVSSVSKASAKIKSHHNVGGLPAHMKLKLIEPLRYLFKDEVRLLGKELG
LPDEMIWRQPFPGPGLAIRIIGEVTREKLEILRSADWIVMSEIKKAKMYHQVWQSFAILTDVKSVGVMGDFRTYGYLVAI
RAVTSEDAMTADWAKLPYDLLSIISNRIVNEVKEVNRVVYDISSKPPSTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-137 55
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-137 55
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 3e-137 55
guaA NP_938969.1 GMP synthase Not tested Not named Protein 6e-124 52