Gene Information

Name : guaA (SSP2322)
Accession : YP_302412.1
Strain : Staphylococcus saprophyticus ATCC 15305
Genome accession: NC_007350
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2402437 - 2403978 bp
Length : 1542 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGAAATGGCGAAAGAGCAAGAGCTCATACTTGTTTTAGACTTTGGTAGCCAATACAACCAATTAATTACACGACGCAT
TCGTGAAATGGGTGTATATAGTGAATTACATGACCACGAGATTAGCATGGAAGAAATTAAACGTTTAAATCCTAAAGGGA
TTATCCTTTCTGGTGGTCCTAACTCAGTTTATGAAGAAGATTCATTCACAATTGACCCAGAAATTTATAACTTGGGAGTA
CCTATTTTAGGTATTTGTTATGGTATGCAACTAACTACAAAACTTTTAGGTGGAAAAGTAGAGCGTGCCAATGAACGTGA
ATATGGTAAAGCCATTATTAATGCGAAGACTGATGAGTTATTCTTTGGTTTACCAGAAGAACAAAATGTTTGGATGAGCC
ACTCAGATAAAGTGATCGAAATTCCAGAAGGTTTCGAAGTGATTGCTGATAGCCCAAGTACCAACTATGCAGCAATTGAA
GATAAATCTCGTCGCATCTATGGTGTGCAATTCCACCCAGAAGTACGTCACACAGAATACGGAAACGATTTACTTCGTAA
CTTTGTACGTCGTGTATGTGACTGTATAGGTGAATGGTCAATGGAAAACTTCATTGAGATTGAAATTGAAAAAATTCGTA
ATCAAGTTGGCGACCGTAAAGTCCTATGTGCGATGAGTGGTGGCGTAGACTCATCTGTAGTAGCTGTATTGTTACACAAA
GCGATTGGCGACCAACTGACGTGTATCTTTGTAGACCATGGTTTATTACGTAAAGGCGAAGGCGACATGGTTATGGAACA
ATTTGGTGAAGGTTTCAACATGAATATTATTCGTGTCGATGCACAAGAACGATTCATGAGCAAATTACAAGGTGTTTCTG
ATCCAGAACAAAAACGTAAAATCATTGGTAATGAATTCATCTATGTATTTGATGATGAAGCATCTAAATTAAAAGGTGTG
GATTTCTTAGCACAAGGCACATTATATACAGACGTTATCGAATCTGGTACGAAGACAGCACAAACAATCAAATCACACCA
CAATGTGGGTGGTTTACCAGAAGACATGGAGTTCCAATTAATCGAACCCATCAATACACTGTTTAAAGATGAAGTGCGTG
AATTAGGTATCGAGTTAGGTATTCCTGAACATTTAGTATGGAGACAGCCGTTCCCAGGTCCTGGATTAGGTATCCGTGTA
CTTGGTGAAATCACAGAAGACAAACTTGAAATTGTACGTGAATCAGACGCCATTTTAAGACAGGTCATCCGTGAGGAAGG
TCTTGAACGTGAGATTTGGCAGTATTTCACAGTGTTACCTGGCATCCAATCTGTAGGTGTTATGGGAGACTACCGTACAT
ACGATCACACGGTAGGCATCCGCGCTGTTACATCGATTGATGGTATGACAAGTGACTTTGCACGTATCGACTGGGAAGTC
TTACAGAAGATTTCTAGTCGTATTGTAAATGAAGTGGACCACGTTAACCGCGTTGTCTATGACATTACATCTAAGCCACC
AAGCACAATTGAGTGGGAATAA

Protein sequence :
MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISMEEIKRLNPKGIILSGGPNSVYEEDSFTIDPEIYNLGV
PILGICYGMQLTTKLLGGKVERANEREYGKAIINAKTDELFFGLPEEQNVWMSHSDKVIEIPEGFEVIADSPSTNYAAIE
DKSRRIYGVQFHPEVRHTEYGNDLLRNFVRRVCDCIGEWSMENFIEIEIEKIRNQVGDRKVLCAMSGGVDSSVVAVLLHK
AIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVDAQERFMSKLQGVSDPEQKRKIIGNEFIYVFDDEASKLKGV
DFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFQLIEPINTLFKDEVRELGIELGIPEHLVWRQPFPGPGLGIRV
LGEITEDKLEIVRESDAILRQVIREEGLEREIWQYFTVLPGIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEV
LQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 0.0 95
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 0.0 95
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 0.0 95
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-129 50