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Name : ureC (PMN2A_1055) Accession : YP_292248.1 Strain : Prochlorococcus marinus NATL2A Genome accession: NC_007335 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 1547501 - 1549210 bp Length : 1710 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGCCTTTCAAAATTTCTCGCCAAGCCTATGCAGAGACTTATGGTCCGACGAAAGGCGATCGCATTAGACTTGCAGATAC GGACTTAATACTCGAAGTTGAACAGGATCATACTCACTATGGAGACGAAGTTAAATTTGGTGGGGGAAAAGTTATTCGTG ATGGGATGGGACAATCACAACAAAGTAGAGACAATGGAGTAGTAGATACAGTTATCACAAATGCGCTAATTTTGGATTGG TGGGGAATTGTTAAAGCTGATATTGGCATCAAAGACGGAAAAATCTCAGGTATCGGAAAAGCTGGAAATCCGGATACTCA AGAAGGTGTCAACATTATTGTAGGCGCCAGTACTGAAGCAATCGCAGGAGAAGGAAGCATTATTACTGCAGGAGCTATTG ATAGTCACATTCACTTTATCTGTCCGCAACAAATAGAAACTGCTTTAGCTAGTGGGGTTACCACAATGCTCGGAGGAGGG ACAGGACCAGCAACAGGTACTAATGCAACGACATGTACACCTGGAGCATTTCACATCTCAAGAATGCTGCAATCTGCAGA GGGATTTCCTGTTAATTTGGGATTCTTTGGAAAAGGCAATGCAACTAACAAAGCAGCATTAGAAGAACAAGTAAGAGCAG GTGCTTGTGGGTTAAAACTGCATGAAGACTGGGGAACAACACCGGCCTGTATTGATTCCTGCCTAAGTGTTGCAGATCAA CTAGACGTACAAGTTTGTATTCATACAGATACCCTAAATGAAGCTGGTTTTGTTGAAGATACAATTAAGGCAATAAGAGG GCGAACAATTCATACCTTCCATACAGAAGGAGCGGGAGGTGGTCACGCTCCCGACATTATCAAAATTTGTGGAGAATCAA ATGTGATTCCCAGCAGTACAAATCCAACTAGGCCTTTCACTCTAAATACTCTTGAAGAGCATTTAGACATGTTGATGGTG TGTCATCATTTAGATCCCAAAATTCCAGAGGATGTTGCATTTGCTGAGTCAAGAATACGTCGTGAAACTATTGCTGCTGA GGACATACTCCACGACTTAGGAGCCTTTTCTATTATTGCTAGTGACTCCCAGGCTATGGGTAGAGTTGGGGAGGTGATTA GCCGGACTTTTCAAACTGCTCATAAAATGAAAGTTCAAAGAGGAGCCTTACCTGAGGATAATCAAAGGAATGATAATCAT CGTCTGAAAAGATATATCTCAAAAGTCACTATTAATCCTGCGATAGCTCATGGAATCAGTGCTCATGTTGGTTCGGTAGA AGTTGGAAAACTAGCAGACTTAGTACTTTGGAAGCCAGGTTTTTTTGGAATTAAACCTGACTTAGTAGTCAAAGGAGGAT GTATCGCATGGGCTCAAATGGGAGATGCAAATGCCTCGATTCCTACTCCACAACCAGTTCATGGTCGTCCAATGTTTTCT TCCTTTGGAAAGGCAATAAATCCTACATGTCTGACTTTCTTAAGCGAGAGTGCAATAGACGCTGGTGTCCCTGAACGACT CAAATTGGAACGTTCTTATGCTCCCGTTAAAGACACAAGAAAAATATCTAAACAATCAATGAAACTTAATGATGCAAGAC CAAAAATCGAAGTAGACCCCCAAACATATGAAGTTTTTGCAAACGGAGAGCTTTTGACTTGTGAACCTGCTGAATTACTA CCACTTGCACAAAGATATCTATTACTTTAG Protein sequence : MPFKISRQAYAETYGPTKGDRIRLADTDLILEVEQDHTHYGDEVKFGGGKVIRDGMGQSQQSRDNGVVDTVITNALILDW WGIVKADIGIKDGKISGIGKAGNPDTQEGVNIIVGASTEAIAGEGSIITAGAIDSHIHFICPQQIETALASGVTTMLGGG TGPATGTNATTCTPGAFHISRMLQSAEGFPVNLGFFGKGNATNKAALEEQVRAGACGLKLHEDWGTTPACIDSCLSVADQ LDVQVCIHTDTLNEAGFVEDTIKAIRGRTIHTFHTEGAGGGHAPDIIKICGESNVIPSSTNPTRPFTLNTLEEHLDMLMV CHHLDPKIPEDVAFAESRIRRETIAAEDILHDLGAFSIIASDSQAMGRVGEVISRTFQTAHKMKVQRGALPEDNQRNDNH RLKRYISKVTINPAIAHGISAHVGSVEVGKLADLVLWKPGFFGIKPDLVVKGGCIAWAQMGDANASIPTPQPVHGRPMFS SFGKAINPTCLTFLSESAIDAGVPERLKLERSYAPVKDTRKISKQSMKLNDARPKIEVDPQTYEVFANGELLTCEPAELL PLAQRYLLL |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 4e-158 | 68 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 4e-158 | 68 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-154 | 61 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-156 | 61 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 3e-156 | 61 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-156 | 61 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_292248.1 | urease subunit alpha | VFG0270 | Protein | 9e-148 | 65 |
