Gene Information

Name : Tfu_0440 (Tfu_0440)
Accession : YP_288501.1
Strain : Thermobifida fusca YX
Genome accession: NC_007333
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.1
Position : 498682 - 499827 bp
Length : 1146 bp
Strand : +
Note : catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine

DNA sequence :
ATGAGTTACGAGGGGTTTGAGACACTGGCCATCCACGCCGGTCAGGAGGCAGACGCCGAGACCGGGGCCGTGGTGGTCCC
CATCTACCAGACGAGCACCTACCGCCAAGACGGGGTGGGCGGGCTGCGCGGCGGCTACGAGTACTCCCGCACCGCCAACC
CGACCCGCACGGCACTGGAAGAATGCCTGGCCGCGCTGGAAGGCGGGGTGCGGGGCCTGGCGTTCGCTTCCGGCATGGCC
GCAGAGGACACCCTGCTCCGCACCATCGCCCGACCCGGCGACCACCTCATCATCCCCAACGACGCCTACGGCGGCACGTT
CCGCCTCGTCTCCAAGGTCTTCGAACGGTGGGGAGTGAGCTGGGACGCCGTCGACCTGTCCAACCCGGAGGCGGTGCGGA
CCGCAATCCGCCCGGAAACCGTGGCGATCTGGGTGGAAACCCCCACCAACCCGCTGCTCAACATTGCGGACATCGCCGCG
CTCGCGGACATCGCGCACGCCGCTGACGCGCTGCTGGTGGTCGACAACACCTTCGCCTCCCCGTACCTGCAGCGGCCGCT
CAGCCTCGGTGCGGACGTGGTCGTGCACTCCACCACCAAATACCTGGGCGGCCACTCCGACGTGGTCGGCGGCGCCCTCG
TGGTCGCCGACGCGGAACTGGGAGAGCGCCTCGCCTTCCACCAGAACTCGATGGGCGCGGTCGCGGGACCGTTCGACGCC
TGGCTGACCCTGCGCGGCATCAAAACCCTCGGCGTGCGCATGGACCGGCACTGCGCCAACGCGGAACGCGTCGTGGAAGC
GCTCGTCGGCCACCCGGAAGTCGCCGAAGTGCTCTACCCGGGCCTGTCCGACCACCCCGGCCACAAGGTGGCGGTCGACC
AGATGCGCGCCTTCGGTGGCATGGTGTCGTTCCGCATGCGCGGCGGGGAGGAAGCCGCGTTGCGGGTGTGCGCGAAAACG
AAAGTGTTCACCCTCGCTGAATCCTTGGGCGGGGTGGAGTCGCTGATCGAACACCCGGGGAAGATGACCCACGCCTCCAC
CGCGGGCTCCCTCCTGGAAGTGCCCAGCGACCTGGTCCGGCTCTCCGTGGGTATCGAAACCGTCGACGACCTCGTCAACG
ACCTGCTCCAAGCATTGGAGCCGTAG

Protein sequence :
MSYEGFETLAIHAGQEADAETGAVVVPIYQTSTYRQDGVGGLRGGYEYSRTANPTRTALEECLAALEGGVRGLAFASGMA
AEDTLLRTIARPGDHLIIPNDAYGGTFRLVSKVFERWGVSWDAVDLSNPEAVRTAIRPETVAIWVETPTNPLLNIADIAA
LADIAHAADALLVVDNTFASPYLQRPLSLGADVVVHSTTKYLGGHSDVVGGALVVADAELGERLAFHQNSMGAVAGPFDA
WLTLRGIKTLGVRMDRHCANAERVVEALVGHPEVAEVLYPGLSDHPGHKVAVDQMRAFGGMVSFRMRGGEEAALRVCAKT
KVFTLAESLGGVESLIEHPGKMTHASTAGSLLEVPSDLVRLSVGIETVDDLVNDLLQALEP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-73 49
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-74 49
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-52 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tfu_0440 YP_288501.1 cystathionine gamma-synthase BAC0207 Protein 9e-59 45