Gene Information

Name : guaA (Tfu_2589)
Accession : YP_290645.1
Strain : Thermobifida fusca YX
Genome accession: NC_007333
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 3054859 - 3056445 bp
Length : 1587 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGTCCGTTGCCGGTGCTCCCGAGAGCACGTTCGACACCGTTCTCGTCGTGGACTTCGGCGCGCAATACGCGCAGTTGAT
CGCGCGTCGGGTACGCGAATGCCACGTCTACAGCGAGATCGTGCCTCCGACCATGCCGGTCGAGGAGATGCTCGCCAAAA
AACCCAAGGCCATCATCCTGTCGGGTGGCCCCTCCTCGGTGTACGCCGACGGAGCCCCGCAAGCTCCCCCCGGCCTGTTC
GACACCGGGGTGCCCATCTTGGGGATCTGCTACGGCTTCCAGGTCATGGCGCAGACCCTCGGCGGCACCGTCGAACGGAC
GGGACGCTCCGAATACGGGCGCACCACGATCAACGTCGCCACCGACAGCCTGCTGTTCCACAGCCTGCCTCAGCAGCAGA
CCGTGTGGATGTCGCACGGCGACGCCGTGTCCCAGGTCCCCGACGGGTTCACCGTCACCGGGCAGACCGCGGACGCCCCG
GTGGCCGCGATGGAGCACCGCGACCGGGCCCTCTACGGGGTCCAGTTCCACCCCGAAGTGGTCCACACCGAGCACGGCCG
GGCCGTGCTGCAGCACTTCCTCTACGAGGCCGCGGGCTGCCGCCCCACCTGGACGATGGTCAACATCGTCGAAGACCAGG
TGGCGCGCATCCGCGCCCAGATCGGCAGCAAGCGGGCGATCTGCGGGCTGAGCGGCGGAGTGGACTCCGCGGTAGCGGCC
GCCCTCGTGCAGCGCGCTATCGGCGACCGTCTGACCTGTGTCTTCGTTGACCACGGGCTGTTGCGCCAAGGGGAAGCGGA
GCAGGTCGAAAAAGACTTCGTCGCCGCTACGGGAGCCAGCCTCAAAGTCGTCGACGCCCAAGAGCGGTTCCTCACCGCTC
TGGCCGGGGTCACCGACCCGGAAACCAAACGCAAGATCATCGGACGCGAGTTCATCCGCGTCTTCGAACAGGCAGCCCGC
GAGATCGTCGCTGAAGCCGGGGAAGGCGACGAAGCCGTCGAATTCCTCGTCCAAGGCACGCTCTACCCGGACGTGGTGGA
GTCCGGGGGCGGCAACGGGACCGCCAACATCAAATCGCACCACAACGTCGGCGGACTCCCCGACGACCTGCAGTTCACCC
TGGTCGAACCGCTCCGGGAGCTGTTCAAGGACGAAGTCCGCAGAGTCGGCGAAGAACTCGGCCTCCCCGCAGAAATGGTG
TGGCGGCACCCCTTCCCCGGCCCGGGCCTGGCCATCCGCATCGTGGGCGAGGTCACCGCGGAGCGGCTGGAGATCCTGCG
GGCAGCCGACGCCATTGTCCGCGAAGAGCTGACCCGAGCCGGACTGGACCGCGCCATCTGGCAGTGCCCGGTGGTGCTGC
TGGCAGACGTGCGCTCCGTGGGGGTGCAAGGCGACGGCCGGACCTACGGCCACCCGATCGTGCTGCGCCCGGTCACCAGC
GAAGACGCCATGACTGCCGACTGGGCCCGGGTCCCCTACGACGTCCTCGCCACGATCTCCAACCGCATCACCAACGAGGT
CCCCGACATCAACCGGGTCACCCTCGACATCACCAGCAAGCCGCCCGGCACGATCGAATGGGAGTGA

Protein sequence :
MSVAGAPESTFDTVLVVDFGAQYAQLIARRVRECHVYSEIVPPTMPVEEMLAKKPKAIILSGGPSSVYADGAPQAPPGLF
DTGVPILGICYGFQVMAQTLGGTVERTGRSEYGRTTINVATDSLLFHSLPQQQTVWMSHGDAVSQVPDGFTVTGQTADAP
VAAMEHRDRALYGVQFHPEVVHTEHGRAVLQHFLYEAAGCRPTWTMVNIVEDQVARIRAQIGSKRAICGLSGGVDSAVAA
ALVQRAIGDRLTCVFVDHGLLRQGEAEQVEKDFVAATGASLKVVDAQERFLTALAGVTDPETKRKIIGREFIRVFEQAAR
EIVAEAGEGDEAVEFLVQGTLYPDVVESGGGNGTANIKSHHNVGGLPDDLQFTLVEPLRELFKDEVRRVGEELGLPAEMV
WRHPFPGPGLAIRIVGEVTAERLEILRAADAIVREELTRAGLDRAIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVTS
EDAMTADWARVPYDVLATISNRITNEVPDINRVTLDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 6e-171 70
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 4e-142 52
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-142 52
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 4e-142 52