Gene Information

Name : guaA (Daro_2337)
Accession : YP_285543.1
Strain : Dechloromonas aromatica RCB
Genome accession: NC_007298
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2518639 - 2520273 bp
Length : 1635 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGTCTCACCAGAAAATCCTCATCCTCGATTTCGGTTCCCAGGTCACTCAGCTGATCGCCCGTCGCGTGCGCGAAGCGAA
GGTCTTCTGCGAAATTCATCCGTACGACGTTTCCGAAGAATTTATTCGCAATTACGGCGCCAAGGGCATCATCTTGTCGG
GTGGCCCAAGTTCGGTGACCGAGGGTGATACGCCGCGAGCGCCGGAAGTGGTTTTCCAACTCGGTGTTCCGGTTCTCGGC
ATTTGCTACGGCATGCAGACCATGGCCCAGCAACTGGGTGGCAAGGTGATGACCGCCGAGGCAGCGGGCAAATCCCGCGA
ATTTGGCTACTCGGAAGTCCGCGCCCACGGCCACACGGCACTGCTCAACGATATTGCCGACTTTTATAGTCCGGAAGGTC
ACGGCATGCTCAAGGTCTGGATGAGCCACGGCGATTCGGTCATGGAACTGCCGGCCGGCTTCGTCAAGATGGCTTCGACC
GCCTCGTGCCCGATTGCGGCGATGGCCGACGAGAGCCGCAAGTTCTACGCTGTTCAGTTCCACCCGGAAGTGACGCACAC
CCAGCAGGGCCGCGCCATCCTCGAACGTTTCGTGCATGGCATCTGCGGCTGTGGCACTGACTGGGTCATGGGCGACTACA
TCGCCGAGGCGGTCGATGCCATCCGGCGTCAGGTCGGCGACGAGGAAGTCATTCTCGGCCTGTCCGGCGGTGTCGATTCC
AGTGTTGCCGCGGCGCTGATCCACAAGGCAATCGGCGACCAGCTGACCTGCGTTTTTGTCGATCACGGCCTGCTACGCCT
GAACGAAGGCGACATGGTGATGGAGATGTTTGCCCGTAATCTTGGCGTCAAGGTCATCCGTGTAGATGCCGTTGATGACT
TCATGGGCAAGCTGGCCGGTGTCTCCGACCCCGAGCAGAAGCGCAAGATCATCGGTAAGGAATTCGTGGAAGTTTTCCAG
GTTGAATCCAAAAAGCTTGCCGCTGCCAAGTGGCTGGCCCAGGGCACGATCTACCCGGACGTGATCGAGTCGGCCGGCAA
GGGCAAGAAGGGCGCTCACACGATCAAGAGCCACCATAACGTTGGCGGCCTGCCGGAAGATATGCACCTCAAATTGCTTG
AGCCGCTGCGTGAGTTGTTCAAGGACGAAGTCCGTGAACTGGGCATTGCCCTCGGACTGCCACGCGAGATGGTGTATCGC
CACCCGTTCCCGGGGCCGGGCTTAGGGGTTCGGATTCTTGGCGAAGTCACGCTGAAGGCGGCTCATCTGTTGCAACGCGC
TGATGCCATTTTCATCGATGAACTGCGTGCCACCCACGCAACCGAACGTGATGTGGCGGCCGGTGCCTGCACTGAAGCCG
ACATCGGCAAGAGCTGGTACGACCTGACCAGCCAGGCCTTTGCCGTTTTCCTGCCAGTCAAGAGCGTTGGCGTGATGGGG
GATGGTCGGACCTACGAGAATGTCGTCGCCTTGCGCGCCGTGGTGACCAGCGACTTCATGACGGCACACTGGGCGCACCT
TCCGTATGAGCTGCTTGGCCGGGTTTCCAATCGCATCATCAACGAAGTCCGGGGTCTGAACCGCGTTGTTTATGACGTGT
CAGGCAAGCCGCCGGCTACGATCGAGTGGGAATAA

Protein sequence :
MSHQKILILDFGSQVTQLIARRVREAKVFCEIHPYDVSEEFIRNYGAKGIILSGGPSSVTEGDTPRAPEVVFQLGVPVLG
ICYGMQTMAQQLGGKVMTAEAAGKSREFGYSEVRAHGHTALLNDIADFYSPEGHGMLKVWMSHGDSVMELPAGFVKMAST
ASCPIAAMADESRKFYAVQFHPEVTHTQQGRAILERFVHGICGCGTDWVMGDYIAEAVDAIRRQVGDEEVILGLSGGVDS
SVAAALIHKAIGDQLTCVFVDHGLLRLNEGDMVMEMFARNLGVKVIRVDAVDDFMGKLAGVSDPEQKRKIIGKEFVEVFQ
VESKKLAAAKWLAQGTIYPDVIESAGKGKKGAHTIKSHHNVGGLPEDMHLKLLEPLRELFKDEVRELGIALGLPREMVYR
HPFPGPGLGVRILGEVTLKAAHLLQRADAIFIDELRATHATERDVAAGACTEADIGKSWYDLTSQAFAVFLPVKSVGVMG
DGRTYENVVALRAVVTSDFMTAHWAHLPYELLGRVSNRIINEVRGLNRVVYDVSGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 8e-126 51
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-125 51
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-125 51
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-110 46