Gene Information

Name : secA (M5005_Spy_1534)
Accession : YP_282897.1
Strain : Streptococcus pyogenes MGAS5005
Genome accession: NC_007297
Putative virulence/resistance : Unknown
Product : preprotein translocase subunit SecA
Function : -
COG functional category : U : Intracellular trafficking, secretion and vesicular transport
COG ID : COG0653
EC number : -
Position : 1492295 - 1494814 bp
Length : 2520 bp
Strand : -
Note : functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis ap

DNA sequence :
ATGGCCAATATTCTACGCAAAGTTATCGAAAATGACAAAGGCGAACTAAGAAAATTAGAAAAAATTGCAAAAAAAGTAGA
ATCCTACGCAGACCAAATGGCGTCATTGTCGGATAGAGATCTACAAGGAAAAACACTTGAATTTAAAGAACGCTATCAAA
AAGGTGAGACCCTCGAACAACTATTACCTGAAGCTTTCGCAGTTGTTCGTGAAGCAGCAAAACGTGTGTTGGGCTTGTTC
CCTTATCGTGTTCAAATTATGGGAGGAATTGTTCTTCATAACGGGGATGTCCCTGAAATGCGTACTGGTGAAGGAAAAAC
TCTTACAGCCACCATGCCAGTTTATCTCAATGCTATTGCTGGTGAGGGTGTTCACGTTATTACTGTTAATGAGTATCTTT
CAACGCGTGACGCTACCGAAATGGGTGAAGTGTATAGCTGGTTAGGTCTTTCAGTTGGGATCAACCTAGCTGCTAAGTCT
CCTGCTGAAAAACGTGAAGCTTATAATTGTGATATTACTTATTCAACCAACTCTGAAGTCGGTTTTGATTACCTTCGTGA
CAACATGGTTGTTCGCCAGGAAGACATGGTACAACGCCCACTCAATTTTGCCTTGGTTGATGAAGTGGACTCAGTCTTAA
TTGACGAGGCAAGGACACCTTTAATTGTTTCTGGTGCTGTTAGCTCTGAAACCAATCAATTGTATATTCGTGCTGACATG
TTTGTAAAAACTCTGACGTCAGTGGATTATGTTATTGATGTGCCCACTAAAACGATTGGATTAAGCGATTCAGGTATTGA
TAAAGCTGAGAGTTACTTTAACTTGAGCAATCTTTACGATATTGAAAATGTAGCCTTGACTCACTTTATAGACAACGCCC
TTCGTGCAAACTATATTATGTTGTTAGATATCGATTATGTGGTCAGCGAAGATGGTGAGATTCTTATTGTTGACCAATTT
ACAGGTCGTACGATGGAAGGGCGTCGCTTCTCAGACGGCTTGCACCAAGCTATTGAGGCAAAAGAAGGCGTTCGTATTCA
GGAAGAATCAAAAACCAGCGCCTCAATCACTTACCAAAATATGTTTCGTATGTACAAAAAATTGGCAGGTATGACTGGTA
CTGCGAAGACCGAGGAAGAAGAATTTCGCGAAGTTTATAACATGCGTATTATTCCAATTCCAACCAATCGTCCAATTGCC
CGTATTGATCACACTGATTTGCTTTACCCGACCTTAGAATCAAAGTTTAGAGCAGTTGTGGAAGACGTTAAAACGCGTCA
TGCAAAAGGACAACCTATCCTTGTAGGTACGGTTGCTGTTGAAACTAGTGATTTGATTTCACGCAAGCTGGTTGAAGCAG
GGATTCCTCATGAGGTTTTGAATGCTAAAAATCACTTTAAAGAAGCTCAAATCATTATGAATGCTGGGCAACGTGGTGCT
GTTACAATCGCAACTAACATGGCTGGTCGTGGTACTGATATCAAGCTTGGTGAAGGTGTTCGTGAACTTGGTGGGTTATG
TGTCATTGGTACAGAGCGTCATGAAAGCCGTCGTATCGATAACCAGCTTCGTGGACGTTCAGGTCGTCAAGGAGATCCAG
GTGAATCCCAATTCTATCTTTCATTAGAAGATGATTTGATGAGACGTTTCGGCTCTGATCGTATAAAAGCCTTTTTGGAT
CGGATGAAATTAGATGAAGAAGACACTGTTATTAAATCAGGTATGTTAGGGCGTCAAGTGGAATCTGCTCAAAAACGGGT
TGAAGGAAATAACTATGATACCCGTAAACAGGTCTTACAATATGATGATGTGATGCGTGAACAGCGTGAAATTATCTATG
CTAACCGTCGTGATGTCATAACTGCTAATCGAGATCTTGGCCCAGAAATTAAAGCTATGATCAAGCGTACTATCGACCGT
GCTGTAGATGCTCATGCACGTAGCAATCGTAAAGATGCTATAGATGCTATTGTAACTTTTGCTAGGACCTCGCTGGTACC
AGAAGAGTCTATTAGTGCTAAAGAGTTACGTGGTTTAAAAGATGATCAAATCAAAGAGAAGCTTTATCAAAGAGCGCTTG
CTATCTACGACCAGCAACTATCAAAACTTCGTGATCAAGAAGCTATTATTGAATTCCAAAAAGTACTCATTTTGATGATT
GTGGATAACAAATGGACTGAACACATTGATGCCTTAGATCAACTTCGTAATGCTGTTGGACTTCGGGGGTATGCTCAAAA
TAACCCTGTGGTGGAATACCAAGCAGAAGGTTTCAAGATGTTCCAAGATATGATTGGTGCTATCGAGTTTGATGTAACAC
GTACCATGATGAAAGCACAAATTCACGAACAAGAACGTGAACGTGCAAGTCAACGTGCCACAACAGCAGCACCTCAAAAC
ATCCAATCGCAGCAGTCAGCTAACACCGATGATTTACCCAAAGTGGAGCGTAACGAAGCTTGTCCATGTGGTTCAGGCAA
AAAATTCAAAAATTGTCACGGTCGTAAATCCTTCTCATAA

Protein sequence :
MANILRKVIENDKGELRKLEKIAKKVESYADQMASLSDRDLQGKTLEFKERYQKGETLEQLLPEAFAVVREAAKRVLGLF
PYRVQIMGGIVLHNGDVPEMRTGEGKTLTATMPVYLNAIAGEGVHVITVNEYLSTRDATEMGEVYSWLGLSVGINLAAKS
PAEKREAYNCDITYSTNSEVGFDYLRDNMVVRQEDMVQRPLNFALVDEVDSVLIDEARTPLIVSGAVSSETNQLYIRADM
FVKTLTSVDYVIDVPTKTIGLSDSGIDKAESYFNLSNLYDIENVALTHFIDNALRANYIMLLDIDYVVSEDGEILIVDQF
TGRTMEGRRFSDGLHQAIEAKEGVRIQEESKTSASITYQNMFRMYKKLAGMTGTAKTEEEEFREVYNMRIIPIPTNRPIA
RIDHTDLLYPTLESKFRAVVEDVKTRHAKGQPILVGTVAVETSDLISRKLVEAGIPHEVLNAKNHFKEAQIIMNAGQRGA
VTIATNMAGRGTDIKLGEGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMRRFGSDRIKAFLD
RMKLDEEDTVIKSGMLGRQVESAQKRVEGNNYDTRKQVLQYDDVMREQREIIYANRRDVITANRDLGPEIKAMIKRTIDR
AVDAHARSNRKDAIDAIVTFARTSLVPEESISAKELRGLKDDQIKEKLYQRALAIYDQQLSKLRDQEAIIEFQKVLILMI
VDNKWTEHIDALDQLRNAVGLRGYAQNNPVVEYQAEGFKMFQDMIGAIEFDVTRTMMKAQIHEQERERASQRATTAAPQN
IQSQQSANTDDLPKVERNEACPCGSGKKFKNCHGRKSFS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
secA2 YP_006310687.1 preprotein translocase subunit SecA2 Not tested FWisland_3 Protein 2e-143 41