Gene Information

Name : nrdE.1 (M28_Spy0336)
Accession : YP_279805.1
Strain : Streptococcus pyogenes MGAS6180
Genome accession: NC_007296
Putative virulence/resistance : Unknown
Product : ribonucleotide-diphosphate reductase subunit alpha
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0209
EC number : 1.17.4.1
Position : 356078 - 358258 bp
Length : 2181 bp
Strand : +
Note : Catalyzes the rate-limiting step in dNTP synthesis

DNA sequence :
ATGTCACAAACCAATGCGTCATACCTCTCATTAAATGCACTGACCCGTTTTAAAAAACCAGACGGCAGCTACCATTTTGA
TAGCGATAAAGAAGCTGTTAGGCGCTACCTGGAAGAACATGTCTCTCCCAATCAAATGGCTTTTAACTCACTAGAAGATA
AGCTAGCTTACCTCATCAATGAAGGGTATTATGAGCAGGCCATTTTTGATGCCTATCCTAACGACCTTATCAAGGAGGCC
TTTCATTATGCCTATCAACAAGGCTATCGCTTTTTAAATCTCATGGGCGCTATGAAATTTTACCAGTCCTATGCCTTAAA
AACCTTGGACGGTAAGCAGTATCTAGAAACATTTGAAGACCGTGCTGTGATGAATGCACTCTTTTTAGCTGATGGAGATC
AAACCTTTGTCTTTGACGTGATTGATGCCATCTTGCACCGACGCTTTCAACCAGCTACCCCAACGTTTTTAAATGCCGGA
AAAAAACGCCGTGGCGAATACATTTCGTGCTATCTTCTTCGTGTCGAAGACAATATGGAATCTATCTCTCGCGCCATTAG
CACCAGCTTGCAACTCTCAAAAAGAGGAGGCGGAGTCGCCTTGTGCCTCACCAACCTCAGAGAAATCGGAGCACCGATAA
AAGGGATTGAAAATCAGGCAACAGGCATCGTTCCTGTCATGAAACTACTAGAGGACTCTTTTTCCTATGCCAATCAACTA
GGTCAGCGCCAAGGAGCAGGTGCGGTTTACCTTCATGCCCATCATCCTGAGGTCTTGACCTTTTTAGACACCAAACGTGA
AAATGCCGATGAGAAAATTCGCATTAAGTCCCTAGCATTGGGACTTGTGATCCCAGATATTACCTTCCAGTTAGCCAAAG
AAAACAAAGACATGGCTCTCTTTTCACCCTATGATATCAAGCGTGCCTATGGCAAGGACATGTCAGACATCTCCATCACA
GAGGAATACGATAAACTGCTAGCCAATCCAGCCATCAAAAAGACCTACATCAGTGCTAGAAAGTTCTTTCAGTTAATTGC
AGAGCTACATTTTGAGTCAGGCTACCCTTACCTCTTGTTTGATGACACGGTCAATAAGCGCAATCCTCATGCCAAAAAAG
GCAGAATCGTCATGTCTAACCTGTGTTCTGAAATCGCTCAAGTCAGCACCCCAAGCACTTTCAAAGAAGATTTGAGTTTT
GAAACCATTGGAGAGGATATCTGCTGTAATTTAGGGTCTATCAATATTGCCCAGGCTATGGCAGATGCGCCACACTTTGA
ACAGCTCATCACAACGAGCATCAGAGCACTTGATCGTGTCTCTAGAGTGTCTGACCTGAATTGTGCGCCTTCTGTTGAGA
CAGGCAATGCAGCCAACCATGCAGTAGGATTAGGCGCCATGAACCTACATGGGTTTTTGGCAACCAACCACATCTACTAT
GATACAAAAGAAGCCGTTGACTTTACAGATCTGTTTTTCCATGCCATGGCCTATTATGCTTTTAAAGCCTCTTGCCAATT
AGCCAAAGAAAAAGGCGCTTTTGCAGGATTTTCGTTATCAACCTATGCAGATGGCACTTATTTTGCCAAGTATTTGCAAG
AAGATGCCAAGCCACAAACAGCCAAGGTTGCCACATTGTTGCAAGATTACGGCTTCACATTGCCAACGGTGGCGGATTGG
CAAGCCCTAGTAGCAGATATCAAGCAGTTTGGTCTAGCCAATGCGCACTTGCTAGCGGTTGCTCCGACAGGCTCCATCAG
CTACTTATCATCCTGCACTCCGAGTCTACAACCAGTCGTTGCTCCTGTTGAGGTCCGAAAAGAAGGTAGCCTGGGCAGGA
TTTACGTCCCTGCCTATCAGATTGACCAGGCTAACTATGCTTACTATGAACGTGGTGCCTATGAGGTCGGCCCAAAAGCC
ATCATCGACGTTGTAGCTGCTGCCCAAAAACACGTTGACCAAGCCATCTCATTGACCCTGTTTATGACCGATCAAGCGAC
CACACGTGACCTTAACCGCTCCTATATCCAAGCTTTTAAGCAAAACTGTGCATCGATCTATTATGTGCGAGTGAGGCAAG
ACGTCCTAGCAGGCAGCGAACAGTATGACGAGGATAGTCTTGTGACAGCTCCTGGAGCTAGTGATGAGACCACCACAGAG
TGTCAAAGCTGTATGATCTAA

Protein sequence :
MSQTNASYLSLNALTRFKKPDGSYHFDSDKEAVRRYLEEHVSPNQMAFNSLEDKLAYLINEGYYEQAIFDAYPNDLIKEA
FHYAYQQGYRFLNLMGAMKFYQSYALKTLDGKQYLETFEDRAVMNALFLADGDQTFVFDVIDAILHRRFQPATPTFLNAG
KKRRGEYISCYLLRVEDNMESISRAISTSLQLSKRGGGVALCLTNLREIGAPIKGIENQATGIVPVMKLLEDSFSYANQL
GQRQGAGAVYLHAHHPEVLTFLDTKRENADEKIRIKSLALGLVIPDITFQLAKENKDMALFSPYDIKRAYGKDMSDISIT
EEYDKLLANPAIKKTYISARKFFQLIAELHFESGYPYLLFDDTVNKRNPHAKKGRIVMSNLCSEIAQVSTPSTFKEDLSF
ETIGEDICCNLGSINIAQAMADAPHFEQLITTSIRALDRVSRVSDLNCAPSVETGNAANHAVGLGAMNLHGFLATNHIYY
DTKEAVDFTDLFFHAMAYYAFKASCQLAKEKGAFAGFSLSTYADGTYFAKYLQEDAKPQTAKVATLLQDYGFTLPTVADW
QALVADIKQFGLANAHLLAVAPTGSISYLSSCTPSLQPVVAPVEVRKEGSLGRIYVPAYQIDQANYAYYERGAYEVGPKA
IIDVVAAAQKHVDQAISLTLFMTDQATTRDLNRSYIQAFKQNCASIYYVRVRQDVLAGSEQYDEDSLVTAPGASDETTTE
CQSCMI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cur_1481 YP_001800875.1 ribonucleotide-diphosphate reductase subunit alpha Not tested Not named Protein 0.0 55