Gene Information

Name : leuS (M28_Spy0145)
Accession : YP_279614.1
Strain : Streptococcus pyogenes MGAS6180
Genome accession: NC_007296
Putative virulence/resistance : Unknown
Product : leucyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0495
EC number : 6.1.1.4
Position : 162554 - 165055 bp
Length : 2502 bp
Strand : +
Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl

DNA sequence :
ATGACATTTTACGATCACACCGCTATTGAACCCAAATGGCAAGCCTTTTGGGCAGATAATCATACTTTTAAAACAGGAAC
AGACGCATCAAAACCTAAGTTTTATGCCCTAGATATGTTCCCATACCCATCAGGAGCTGGTCTCCACGTTGGTCACCCAG
AAGGCTATACAGCAACGGATATTCTCAGCCGTTTCAAACGTGCCCAAGGTCACAATGTCCTCCACCCAATGGGTTGGGAT
GCCTTTGGACTTCCTGCTGAGCAGTACGCTATGGATACTGGTAATGACCCAGCCGAGTTTACAGCTGAAAACATCGCTAA
CTTCAAACGCCAGATTAATGCTCTTGGTTTCTCATACGACTGGGATCGTGAAGTTAACACAACTGACCCTAACTACTACA
AGTGGACGCAGTGGATCTTTACCAAGCTTTATGAAAAAGGCCTAGCCTACGAAGCTGAAGTTCCCGTTAACTGGGTTGAA
GAATTGGGAACAGCTATCGCCAACGAAGAGGTGCTCCCTGATGGGACATCAGAACGTGGCGGCTACCCAGTTGTCAGAAA
ACCCATGCGCCAATGGATGCTCAAAATCACTGCCTATGCAGAGCGCTTGCTAGAAGACTTGGAAGAAGTTGACTGGCCAG
AATCAATCAAGGACATGCAACGCAACTGGATTGGTAAATCAACTGGTGCTAATGTAACCTTCAAGGTTAAGGATACAGAT
AAGGACTTCACTGTCTTTACAACACGTCCTGACACCCTTTTTGGTGCAACTTACGCGGTTCTTGCTCCTGAGCATGCCTT
GGTTGATGCTATTACAACAGCTGACCAGGCAGAAGCCGTGGCTGACTACAAACGTCAAGCAAGTCTCAAATCAGACCTTG
CTCGTACAGACCTTGCCAAAGAAAAAACTGGTGTCTGGACGGGTAGCTATGCGATTAACCCAGTTAATGGTAACGAAATG
CCAGTTTGGATTGCGGACTATGTCCTTGCCAGCTACGGTACTGGTGCTATCATGGCTGTTCCAGCCCACGATGAACGTGA
CTGGGAATTCGCAAAACAATTTAAGCTAGATATCATTCCAGTTCTTGAAGGTGGTAATGTTGAAGAGGCTGCCTTTACAG
AAGACGGTCTTCACATCAACTCAGACTTCCTAGATGGTCTGGACAAAGCGTCAGCTATTGCCAAAATGGTCGAATGGCTT
GAAGCAGAAGGCGTCGGTAATGAGAAAGTCACTTACCGTCTTCGTGACTGGCTCTTTAGCCGTCAACGTTACTGGGGTGA
GCCAATCCCAATCATCCACTGGGAAGATGGGACCTCAACAGCGGTTCCTGAGAGTGAGTTGCCACTGGTTCTTCCAGTAA
CGAAGGATATCCGTCCTTCAGGTACTGGTGAGAGCCCACTTGCTAACGTGACAGACTGGTTGGAAGTGACTCGTGAAGAT
GGTGTTAAAGGTCGTCGTGAGACTAACACCATGCCACAATGGGCAGGTTCAAGCTGGTACTATCTCCGTTACATCGATCC
ACACAACACCGAAAAACTGGCTGATGAGGAACTCCTCAAACAATGGTTGCCAGTTGATATCTATGTCGGTGGTGCAGAGC
ATGCCGTGCTTCACCTTCTCTACGCTCGCTTCTGGCACAAGGTTCTTTACGATCTCGGTGTCGTACCAACCAAAGAGCCA
TTCCAAAAACTCTTTAACCAAGGGATGATTTTGGGAACAAGCTACCGCGACAGCCGTGGAGCGCTTGTAGCGACTGACAA
GGTTGAAAAACGTGATGGCAGCTTCTTCCATGTGGAAACTGGTGAAGAGCTTGAACAAGCACCAGCTAAGATGTCTAAAT
CACTTAAGAACGTTGTCAACCCAGATGATGTTGTTGAGCAGTACGGTGCTGACACTCTTCGTGTTTACGAGATGTTCATG
GGACCACTTGACGCTTCCATCGCTTGGTCTGAAGAAGGTCTTGAAGGCTCACGTAAGTTCTTGGACCGTGTTTACCGTTT
GATCACAACTAAAGAGATCACTGAGGAAAATAGCGGAGCCCTTGACAAGGTTTACAACGAAACTGTTAAGGCTGTTACTG
AGCAAGTTGACCAAATGAAATTCAACACAGCTATCGCTCAACTCATGGTATTTGTCAATGCAGCCAACAAGGAAGACAAA
CTCTTTAGCGACTATGCCAAAGGCTTCGTTCAATTGATTGCACCATTCGCACCGCACTTAGGTGAGGAACTCTGGCAAGT
CTTGACAGCCTCAGGTGAGTCAATCTCTTACGTGCCATGGCCAAGTTATGATAAAAGCAAATTGGTTGAAAACGATGTGG
AAATCGTTGTCCAAATCAAAGGTAAGGTCAAAGCTAAACTTGTCGTTGCCAAAGACCTTTCACGCGAAGAATTGCAAGAA
GTTGCTCTTGCTAACGAAAAAGTCCAAGCCGAAATCGCAGGCAAAGACATCATCAAAGTCATCGCAGTACCAAACAAACT
CGTTAATATTGTTATCAAATAG

Protein sequence :
MTFYDHTAIEPKWQAFWADNHTFKTGTDASKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGHNVLHPMGWD
AFGLPAEQYAMDTGNDPAEFTAENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVE
ELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKDMQRNWIGKSTGANVTFKVKDTD
KDFTVFTTRPDTLFGATYAVLAPEHALVDAITTADQAEAVADYKRQASLKSDLARTDLAKEKTGVWTGSYAINPVNGNEM
PVWIADYVLASYGTGAIMAVPAHDERDWEFAKQFKLDIIPVLEGGNVEEAAFTEDGLHINSDFLDGLDKASAIAKMVEWL
EAEGVGNEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRPSGTGESPLANVTDWLEVTRED
GVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEELLKQWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEP
FQKLFNQGMILGTSYRDSRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFM
GPLDASIAWSEEGLEGSRKFLDRVYRLITTKEITEENSGALDKVYNETVKAVTEQVDQMKFNTAIAQLMVFVNAANKEDK
LFSDYAKGFVQLIAPFAPHLGEELWQVLTASGESISYVPWPSYDKSKLVENDVEIVVQIKGKVKAKLVVAKDLSREELQE
VALANEKVQAEIAGKDIIKVIAVPNKLVNIVIK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
leuS YP_281511.2 leucyl-tRNA synthetase Not tested Not named Protein 0.0 99