Gene Information

Name : guaA (BPEN_546)
Accession : YP_278033.1
Strain : Candidatus Blochmannia pennsylvanicus BPEN
Genome accession: NC_007292
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 650857 - 652434 bp
Length : 1578 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGAAATGTAACAATCATCGTATTTTAGTAATAGATTTTGGATCTCAATATACTCAGTTGTTGTTGAGAAGAATTCGAGA
ATTAGGAGTATATTCTGAATCTTGTTCTTGGAACATCAGTAAATCTCAAGTATATGCATTTAATCCTAATGGTATTATTC
TTTCTGGAGGTCCTTATAGTGTTATCGATAATGATTCTCCGTATATTCCTGAATTTGTGTTTCAATTAGGTATACCTATA
TTTGGAATTTGTTATGGTATGCAAATTATGTCGTTTCAATTAGGTGGACGAGTAGAACGTGTTATTGCACAGCGTGAATT
TGGTTGTACTCAAGTAACAATTCTTTCTAAAAGCGTTTTTATAAATGATATCTATGATTATGTTGATGATGTTACGGGGC
GTTTTGCTCTTGATGTATGGATGAGTCACGGGGACGTTGTTACTACTGTTCCCAAAGATTTTACGGTTATTGGTGTTAAT
AAGTATCGACAAGTTGCTATGATGGCTAATGAAGATCGTCATTTATATGGTGTTCAATTTCACCCGGAAGTTACCCATAC
TAAAAAAGGAAAAAGTATTTTAGAACGTTTTATTACGTGTATTTGTCGCTGTAAATCTTCTTGGAAAATAGCGAATATTA
TTGATGATATTGTTATGGATACTCGTGTAAAAGTAGGTAATGATAAAGTAGTGCTTGGGTTTTCAGGTGGGATTGATTCC
CTTGTTACAGCTTTATTATTACGACGCGCAATTGGTCATCAATTTATCTGTATTTATATTGATAATGGGTTATTATCAAA
TTATGAATTTGATCGAATTAAAAATTTTTGTGCTCTAAATTGTAATTTAGATATTATTTATTTGTCGCAAGAACAACGAT
TTTTCAATGCTTTAATTGGAGTTAATGATCCAGAAAAAAAAAGAAAAATAATTGGTAGAGTTTTTACAGAAGTTTTTGAA
GAGCAGATTCGTAATTTAGTAGCTGTAAAATGGTTAGCTCAAGGTACTATATATTCAGATGTTATTGAATCTGGTGTATC
TTTATCTTCTTTTAAAAATGTGATTAAATCGCATCATAATGTAGGTGGTTTTTGTGGAATTACGGATATTCAATTACTCG
AGCCTATAAGAAATTTATTTAAAGATGAAGTTCGCAGTATTGGATTAGATTTAGGGATACCTTATGATATAGCTTATCGT
CATCCGTTTCCAGGACCTGGATTGGCTATTAGAATATTAGGTGAAGTAAAAAAAGAATATTGTGATATTTTACGTAGAGT
GGATTTTATTTTTATCGAAGAACTTAAGCGTGAACATTTATATTCCAAAATTAGTCAGGCCTTCGCAGTATTTTTACCAA
CTCATTCAGTAGGAATACAGGGTGATCAGCGTAAGTATAAGTGGGTAATTGCTCTTCGTGCAGTGGAAACTATAGATTTT
ATGACAGCACATTGGGCTTATTTATCTTATGATTTTTTAAATAAGGTATCTAATCGTATCGTCAATGAAGTTGAGGAAGT
ATCTCGTGTGGTGTATGATATTTCCTCAAAACCTCCAGCTACTATTGAATGGGAATAA

Protein sequence :
MKCNNHRILVIDFGSQYTQLLLRRIRELGVYSESCSWNISKSQVYAFNPNGIILSGGPYSVIDNDSPYIPEFVFQLGIPI
FGICYGMQIMSFQLGGRVERVIAQREFGCTQVTILSKSVFINDIYDYVDDVTGRFALDVWMSHGDVVTTVPKDFTVIGVN
KYRQVAMMANEDRHLYGVQFHPEVTHTKKGKSILERFITCICRCKSSWKIANIIDDIVMDTRVKVGNDKVVLGFSGGIDS
LVTALLLRRAIGHQFICIYIDNGLLSNYEFDRIKNFCALNCNLDIIYLSQEQRFFNALIGVNDPEKKRKIIGRVFTEVFE
EQIRNLVAVKWLAQGTIYSDVIESGVSLSSFKNVIKSHHNVGGFCGITDIQLLEPIRNLFKDEVRSIGLDLGIPYDIAYR
HPFPGPGLAIRILGEVKKEYCDILRRVDFIFIEELKREHLYSKISQAFAVFLPTHSVGIQGDQRKYKWVIALRAVETIDF
MTAHWAYLSYDFLNKVSNRIVNEVEEVSRVVYDISSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 4e-106 47
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 4e-106 47
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 6e-106 46
guaA NP_938969.1 GMP synthase Not tested Not named Protein 8e-99 43