Gene Information

Name : lysS (SH2493)
Accession : YP_254408.1
Strain : Staphylococcus haemolyticus JCSC1435
Genome accession: NC_007168
Putative virulence/resistance : Virulence
Product : lysyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : 6.1.1.6
Position : 2501808 - 2503298 bp
Length : 1491 bp
Strand : -
Note : class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA

DNA sequence :
ATGTCAGAAGAAATGAATGACCAAATGCAGGTCCGTCGTCAAAAACTACAAGAATTAATTGATTTAGGAATCGACCCATT
TGGAAAACGTTTTGAGCGCTCAGCTACTGCTAGTGAACTAAAATCACAATGGGATGAATTCTCTAAAGAAGAATTACATG
ATAAAGAAGATGAAAGTCATGTTTCGATTGCCGGACGTTTGATGACTAAACGTGGTAAAGGTAAAGCTGGTTTCGCACAT
GTCCAAGATTTGACTGGTCAGATTCAAATTTACGTGCGTAAGGACCAAATTGGCGAAGAAGATTTCGACAATTTATGGAA
AGGTGCAGACCTAGGCGATATTGTTGGTATTGAAGGTGTAATGTTCAAAACAAATACTGGCGAGCTATCAGTAAAAGCTA
AGACATTCACTTTATTATCTAAAGCGCTTAGACCTTTACCTGATAAGTTCCATGGTTTACAAGATATTGAACAACGTTAT
CGTCAACGTTATTTAGACTTGATTACAAATCAAGATAGTACTCAAACATTTATTAACCGTAGTAAAATTATTCAAGAAAT
GCGTAATTACTTAAATAAACAAGGTTTCTTAGAAGTTGAAACACCAATGATGCATCAAATTGCAGGTGGTGCAGCAGCAC
GACCATTTGTTACGCACCATAATGCACTAGACGCTACTCTTTATATGCGTATAGCAATTGAATTACATTTAAAACGATTA
ATTGTTGGTGGCCTTGAAAAAGTCTATGAAATTGGACGAGTATTCCGTAACGAAGGAGTATCAACACGACATAATCCAGA
ATTTACTATGATTGAATTATATGAAGCATACGCTGATTACCACGATATCATGGATTTAACTGAATCTATGGTAAGACATA
TCGCTCAAGAAGTATTTGGTTCTGCAAAAGTTCAATACAATGAAGAGGAAATTGACCTAGAGTCTGCCTGGACACGCCTT
CATATTGTAGATGCAGTGAAAGAAGCTACAGGTGTAGACTTCTATCAAATTAAATCTGATGAAGAAGCAATCGCTGCAGC
TAAAGAACATGGTATTGAAATTACTAATAATATGAAATATGGTCATATCTTAAATGAATTCTTTGAACAAAAAGTTGAAG
AAACGTTAATTCAACCAACATTTATTTATGGACATCCAATTGAAATCTCGCCTTTAGCGAAGAAAAATCCAGAAGATCCT
AGATTTACAGACCGTTTCGAGTTGTTTATCGTAGGTAGAGAACATGCGAATGCATTCACTGAATTAAATGATCCAATTGA
TCAACGTGAACGTTTCGAAGCACAACTTGTTGAAAAAGCACAAGGTAATGATGAAGCGCATGAAATGGATGAAGATTATA
TTGAAGCTTTGGAATATGGTATGCCTCCAACAGGTGGTTTAGGTATCGGTATCGATCGCTTAGTTATGTTGTTAACTGAC
TCTCCATCTATTAGAGACGTATTATTATTCCCTTACATGAGACAAAAATAG

Protein sequence :
MSEEMNDQMQVRRQKLQELIDLGIDPFGKRFERSATASELKSQWDEFSKEELHDKEDESHVSIAGRLMTKRGKGKAGFAH
VQDLTGQIQIYVRKDQIGEEDFDNLWKGADLGDIVGIEGVMFKTNTGELSVKAKTFTLLSKALRPLPDKFHGLQDIEQRY
RQRYLDLITNQDSTQTFINRSKIIQEMRNYLNKQGFLEVETPMMHQIAGGAAARPFVTHHNALDATLYMRIAIELHLKRL
IVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIELYEAYADYHDIMDLTESMVRHIAQEVFGSAKVQYNEEEIDLESAWTRL
HIVDAVKEATGVDFYQIKSDEEAIAAAKEHGIEITNNMKYGHILNEFFEQKVEETLIQPTFIYGHPIEISPLAKKNPEDP
RFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLVEKAQGNDEAHEMDEDYIEALEYGMPPTGGLGIGIDRLVMLLTD
SPSIRDVLLFPYMRQK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD66193.1 putative lysil-tRNA synthetase LysU Not tested PAI III 536 Protein 4e-120 50

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
lysS YP_254408.1 lysyl-tRNA synthetase VFG1668 Protein 2e-120 50