Gene Information

Name : tpx (NTHI0907)
Accession : YP_248460.1
Strain : Haemophilus influenzae 86-028NP
Genome accession: NC_007146
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : 1.11.1.-
Position : 878258 - 878755 bp
Length : 498 bp
Strand : -
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence : 
ATGACAGTTACATTAGCAGGAAACCCTATTGAAGTTGGCGGACATTTCCCTCAAGTGGGCGAAATAGTAGAAAACTTTAT
TTTAGTCGGTAATGATTTAGCCGATGTTGCATTAAACGATTTTGCAGGTAAACGCAAAGTCCTAAATATTTTTCCAAGCA
TCGACACAGGTGTGTGTGCGACTTCAGTACGTAAATTTAACCAACAAGCGGTAAAATTAAGTAATACTGTTGTGCTTTGT
ATTTCAGCAGACTTGCCCTTTGCTCAAGCTCGTTTTTGTGGAGCTGAAGGGATTGAAAATGCCAAAACAGTTTCGACTTT
CCGTAACCACGCATTACACTCACAATTAGGCGTAGATATTCAAACTGGCCCGTTGGCAGGTTTAACTTCTCGTGCGGTTA
TTGTGTTAGATGAACAAAACAATGTTTTACACAGCCAGTTAGTTGAAGAAATTAAAGAAGAGCCAAACTATGAAGCTGCA
TTGGCAGTGTTAGCGTAG

Protein sequence : 
MTVTLAGNPIEVGGHFPQVGEIVENFILVGNDLADVALNDFAGKRKVLNIFPSIDTGVCATSVRKFNQQAVKLSNTVVLC
ISADLPFAQARFCGAEGIENAKTVSTFRNHALHSQLGVDIQTGPLAGLTSRAVIVLDEQNNVLHSQLVEEIKEEPNYEAA
LAVLA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 1e-36 47
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 8e-37 47
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 8e-37 47
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 1e-36 47

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx YP_248460.1 thiol peroxidase VFG0087 Protein 3e-37 47