Gene Information

Name : metB (NTHI0100)
Accession : YP_247748.1
Strain : Haemophilus influenzae 86-028NP
Genome accession: NC_007146
Putative virulence/resistance : Unknown
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 90633 - 91778 bp
Length : 1146 bp
Strand : -
Note : CGS; O-succinylhomoserine (Thiol)-lyase; catalyzes the formation of cysteine from cystathionine; in B. subtilis also has O-acetylhomoserine thiolyase activity

DNA sequence :
GTGCGGTCAATTTTTTCATTATTTTTAGAGGATGTTATGACACAACAATATGCTATTGATACTTTATTAGCTCAAGCTGG
CAATCGCAGTGATGAGCGTACGGGCGCGGTTTCTGCACCAATTTTTCTTTCTACGGCTTATGGTCATTGTGGTATCGGTG
AAAGTACGGGATTTGATTACACACGTACCAAAAATCCAACTCGCACAGTATTAGAAGAAACGATAGCTAAATTAGAGAAT
GGAGATCGTGGTTTTGCGTTTTCTTCTGGTATGGCTGCAATTCAAGTTTTGATGACGCTTTTTACCGCCCCAGATGAATG
GATTGTTTCTAGCGATGTGTATGGTGGTACTTATCGATTATTAGATTTTTCTTATAAAAATAACAATAGTGTAAAACCTG
TTTATGTTAATACAGCATCTGCTTCAGCAATTGAGGCTGCCATTAACCCAAATACGAAAGCGATTTTTATTGAAACCCCA
TCGAATCCTTTAATGGAAGAATGTGATGTGGTTGAAATTGCAAAACTTGCGAAAAAACATAACTTAATGTTGATCGTGGA
TAATACGTTTTTAACGCCTGTGCTTTCTCGTCCATTAGATTTAGGTGCGGATGTGGTAATTCACAGCGGAACTAAATATA
TTGCTGGGCATAATGATGCACTTGTTGGTTTAATTGTTGCGAAAGGGCAAGAACTTTGTGATCGCATTGCTTATATTCAA
AATGGTGCAGGGGCGGTGCTTTCTCCTTTTGATTCTTGGCTGACTATTCGTGGTATGAAGACCCTTTCTTTGCGTATGAA
ACGCCATCAAGAAAATGCACAAGCCATTGCGGAATTTTTAAAAGCTCAACCACAAGTGGAATCGGTGCTTTATCCAAATA
AAGGTGGGATGTTGTCTTTCCGTTTGCAAGATGAAGCTTGGGTTAATACATTCTTAAAATCCATCAAATTGATTACTTTT
GCAGAAAGTCTAGGCGGCACAGAAAGTTTTATTACTTATCCTGCCACTCAAACTCATATGGATATTCCAGAACCCGAGCG
TGTAGCTCGTGGGATTACTAATACCTTGTTGCGTTTTTCAGTCGGTATTGAAGATGTAGAAGATATTAAAGCGGACTTAT
TACAGGCTTTTGCAAACTTAAAATAA

Protein sequence :
MRSIFSLFLEDVMTQQYAIDTLLAQAGNRSDERTGAVSAPIFLSTAYGHCGIGESTGFDYTRTKNPTRTVLEETIAKLEN
GDRGFAFSSGMAAIQVLMTLFTAPDEWIVSSDVYGGTYRLLDFSYKNNNSVKPVYVNTASASAIEAAINPNTKAIFIETP
SNPLMEECDVVEIAKLAKKHNLMLIVDNTFLTPVLSRPLDLGADVVIHSGTKYIAGHNDALVGLIVAKGQELCDRIAYIQ
NGAGAVLSPFDSWLTIRGMKTLSLRMKRHQENAQAIAEFLKAQPQVESVLYPNKGGMLSFRLQDEAWVNTFLKSIKLITF
AESLGGTESFITYPATQTHMDIPEPERVARGITNTLLRFSVGIEDVEDIKADLLQAFANLK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 3e-68 43
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 4e-69 43